Bayesian Analysis of Simple Random Densities

A tractable nonparametric prior over densities is introduced which is closed under sampling and exhibits proper posterior asymptotics.Comment: 19 pages; 6 figure

Closing the Window on Strongly Interacting Dark Matter with IceCube

We use the recent results on dark matter searches of the 22-string IceCube detector to probe the remaining allowed window for strongly interacting dark matter in the mass range 10^4<m_X<10^15 GeV. We calculate the expected signal in the 22-string IceCube detector from the annihilation ofsuch particles captured in the Sun and compare it to the detected background. As a result, the remaining allowed region in the mass versus cross sectionparameter space is ruled out. We also show the expected sensitivity of the complete IceCube detector with 86 strings.Comment: 5 pages, 7 figures. Uppdated figures 2 and 3 (y-axis normalization and label) . Version accepted for publication in PR

Predictive analysis of microarray data

Microarray gene expression data are analyzed by means of a Bayesian nonparametric model, with emphasis on prediction of future observables, yielding a method for selection of differentially expressed genes and a classifier

Magnetic defects promote ferromagnetism in Zn1-xCoxO

Experimental studies of Zn1-xCoxO as thin films or nanocrystals have found ferromagnetism and Curie temperatures above room temperature and that p- or n-type doping of Zn1-xCoxO can change its magnetic state. Bulk Zn1-xCoxO with a low defect density and x in the range used in experimental thin film studies exhibits ferromagnetism only at very low temperatures. Therefore defects in thin film samples or nanocrystals may play an important role in promoting magnetic interactions between Co ions in Zn1-xCoxO. The electronic structures of Co substituted for Zn in ZnO, Zn and O vacancies, substituted N and interstitial Zn in ZnO were calculated using the B3LYP hybrid density functional in a supercell. The B3LYP functional predicts a band gap of 3.34 eV for bulk ZnO, close to the experimental value of 3.47 eV. Occupied minority spin Co 3d levels are at the top of the valence band and unoccupied levels lie above the conduction band minimum. Majority spin Co 3d levels hybridize strongly with bulk ZnO states. The neutral O vacancy and interstitial Zn are deep and shallow donors, respectively. The Zn vacancy is a deep acceptor and the acceptor level for substituted N is at mid gap. The possibility that p- or n-type dopants promote exchange coupling of Co ions was investigated by computing total energies of magnetic states of ZnO supercells containing two Co ions and an oxygen vacancy, substituted N or interstitial Zn in various charge states. The neutral N defect and the singly-positively charged O vacancy are the only defects which strongly promote ferromagnetic exchange coupling of Co ions at intermediate range.Comment: 9 pages, 11 figure

System dynamics modelling in systems biology and applications in pharmacology

El modelado matemático de sistemas biológicos complejos es uno de los temas clave en la Biología de Sistemas y varios métodos computacionales basados ​​en la simulación computarizada han sido aplicados hasta ahora para determinar el comportamiento de los sistemas no lineales. La Dinamica de Sistemas es una metodología de modelado intuitivo basada en el razonamiento cualitativo por el cual un modelo conceptual se puede describir como un conjunto de relaciones de causa y efecto entre las variables de un sistema. A partir de esta estructura, es posible obtener un conjunto de ecuaciones dinámicas que describan cuantitativamente el comportamiento del sistema. Centrándose en los sistemas farmacológicos, el modelado compartimental a menudo se utiliza para resolver un amplio espectro de problemas relacionados con la distribución de materiales en los sistemas vivos en la investigación, el diagnóstico y la terapia en todo el cuerpo, los órganos y los niveles celulares. En este artículo presentamos la metodología de modelado de Dinámica del Sistema y su aplicación al modelado de un modelo compartimental farmacocinético-farmacodinámico del efecto de profundidad anestésica en pacientes sometidos a intervenciones quirúrgicas, derivando un modelo de simulación en el entorno de simulación orientada a objetos OpenModelica. La Dinamica de Sistemas se puede ver como una herramienta educativa poderosa y fácil de usar y en la enseñanza de Biología de Sistemas.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech