Om Ferieforhold for Landsbygravere m. fl.

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Vedtægt for Landsbykirkegaarde

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Kirkegaardes Økonomi

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Review on possible gravitational anomalies

This is an updated introductory review of 2 possible gravitational anomalies that has attracted part of the Scientific community: the Allais effect that occur during solar eclipses, and the Pioneer 10 spacecraft anomaly, experimented also by Pioneer 11 and Ulysses spacecrafts. It seems that, to date, no satisfactory conventional explanation exist to these phenomena, and this suggests that possible new physics will be needed to account for them. The main purpose of this review is to announce 3 other new measurements that will be carried on during the 2005 solar eclipses in Panama and Colombia (Apr. 8) and in Portugal (Oct.15).Comment: Published in 'Journal of Physics: Conferences Series of the American Institute of Physics'. Contribution for the VI Mexican School on Gravitation and Mathematical Physics "Approaches to Quantum Gravity" (Playa del Carmen, Quintana Roo, Mexico, Nov. 21-27, 2004). Updates to this information will be posted in http://www.lsc-group.phys.uwm.edu/~xavier.amador/anomalies.htm

Identification of membrane calcium channels essential for cytoplasmic and nuclear calcium elevations induced by vascular endothelial growth factor in human endothelial cells.

Vascular endothelial growth factor (VEGF) is mitogenic for endothelial cells and has been shown to induce angiogenesis and endothelial cell migration through stimulation of endothelial tyrosine-kinase receptors. Here, using confocal microscopy and the patch-clamp technique on endothelial cells, membrane permeability to calcium as well as cytoplasmic and nuclear free calcium levels have been investigated in the first stages of tyrosine-kinase receptor activation by VEGF. VEGF (0.5nM) as well as inositol trisphosphate (IP3) induced an activation of membrane calcium-permeable channels exhibiting a similar low conductance in the range of 10 pS. The VEGF-triggered activation of these calcium channels, mediated by IP3 and involving the intracellular calcium stores, results in an increase in both cytoplasmic and nuclear calcium levels in endothelial cells, potentially modulating gene expression. Finally, the effect of Ni2+, a calcium channel blocker, on endothelial cell proliferation has been studied. The results show that inhibition of extracellular calcium influx significantly inhibits VEGF-induced cell proliferation. In the process of cell stimulation by VEGF, and possibly by other growth factors, activation of calcium channels could then be a key step in calcium-regulated gene expression and cell activation. These results suggest that the use of calcium channel blockers could be a novel way of prevention or reversion of VEGF-induced tumoral angiogenesis

Catalogue des larves des col\ue9opt\ue8res, connues jusqu\u27a ce jour : avec la description de plusieurs esp\ue8ces nouvelles /

[Lacks:pg.308-309

Tourniquet-induced changes of energy metabolism in human skeletal muscle monitored by microdialysis. Anesthesiology 93:1407–1412

Background: Tourniquets are often used as part of orthopedic surgery but may cause local and remote organ injury. The authors hypothesized that the procedures used to induce ischemia (circulatory occlusion or exsanguination) may have differential effects on the metabolic state of the muscle that should be reflected in the interstitial levels of metabolites. Methods: Microdialysis probes were implanted in both quadriceps femoris muscles of 18 patients. Interstitial fluid was obtained during tourniquet-induced ischemia and reperfusion and was analyzed for glucose, lactate, choline, and purines by high-performance liquid chromatography. Results: At a flow rate of 2 l/min, the average baseline concentrations in the dialysate were 2.5 mM for glucose, 1.7 mM for lactate, 5.2 M for choline, and 14.3 M for hypoxanthine. Circulatory occlusion by tourniquet caused a 40% decrease of the extracellular glucose concentration within 30 min. Concomitantly, the interstitial levels of lactate and hypoxanthine increased in a linear fashion to 206% (lactate) and 241% (hypoxanthine) of basal values. The extracellular concentration of choline was also significantly elevated. After exsanguination, the glucose levels were significantly more reduced (by 65%), and the levels of lactate (to 268%) and hypoxanthine (to 286%) were more increased than after circulatory occlusion alone. Conclusion: Our microdialysis results demonstrate that the interstitial concentrations of glucose, lactate, and hypoxanthine, which are indicators of tissue ischemia, change more prominently after exsanguination than after circulatory occlusion alone