Genetic Interaction of Centrosomin and Bazooka in Apical Domain Regulation in Drosophila Photoreceptor

Cell polarity genes including Crumbs (Crb) and Par complexes are essential for controlling photoreceptor morphogenesis. Among the Crb and Par complexes, Bazooka (Baz, Par-3 homolog) acts as a nodal component for other cell polarity proteins. Therefore, finding other genes interacting with Baz will help us to understand the cell polarity genes' role in photoreceptor morphogenesis. mutation on developing eyes to determine its role in photoreceptor morphogenesis. We found that Cnn is dispensable for retinal differentiation in eye imaginal discs during the larval stage. However, photoreceptors deficient in Cnn display dramatic morphogenesis defects including the mislocalization of Crumbs (Crb) and Bazooka (Baz) during mid-stage pupal eye development, suggesting that Cnn is specifically required for photoreceptor morphogenesis during pupal eye development. This role of Cnn in apical domain modulation was further supported by Cnn's gain-of-function phenotype. Cnn overexpression in photoreceptors caused the expansion of the apical Crb membrane domain, Baz and adherens junctions (AJs). photoreceptor

Study of a prevention programme for caprine arthritis-encephalitis

International audienc

Databases save time and improve the quality of the design, management and processing of ecopathological surveys

International audienc

Advantages and inconveniences of the Cox model compared with the logistic model: application to a study of risk factors of nursing cow infertility

International audienc

Analysis of associations among diseases in French dairy cows in two consecutive lactations

Associations among diseases in dairy cows were studied on a two-consecutive-lactation basis by means of a longitudinal and prospective study carried out on 24 French herds. Associations between diseases of a given lactation and diseases of the previous lactation were adjusted for breed, parity, milk yield, season of calving, calving interval and type of housing, using multiple logistic regression models with random effects. Five of the 12 associations highlighted are recurrences (clinical mastitis within 5 days after calving, placental retention, lameness other than interdigital pododermatitis, reproductive disorders, milk fever). Otherwise, the study confirms the main role of placental retention in associations among diseases. (Résumé d'auteur