Efficient Numerical Schemes for Computing Cardiac Electrical Activation over Realistic Purkinje Networks: Method and Verification

We present a numerical solver for the fast conduction system in the heart using both a CPU and a hybrid CPU/GPU implementation. To verify both implementations, we construct analytical solutions and show that the L2-error is similar in both implementations and decreases linearly with the spatial step size. Finally, we test the performance of the implementations with networks of varying complexity, where the hybrid implementation is, on average, 5.8 times faster

Effect of Dust Extinction on Estimating Star Formation Rate of Galaxies: Lyman Continuum Extinction

We re-examine the effect of Lyman continuum ($\lambda \leq 912$ \AA) extinction (LCE) by dust in H {\sc ii} regions in detail and discuss how it affects the estimation of the global star formation rate (SFR) of galaxies. To clarify the first issue, we establish two independent methods for estimating a parameter of LCE ($f$), which is defined as the fraction of Lyman continuum photons contributing to hydrogen ionization in an H {\sc ii} region. One of those methods determines $f$ from the set of Lyman continuum flux, electron density and metallicity. In the framework of this method, as the metallicity and/or the Lyman photon flux increase, $f$ is found to decrease. The other method determines $f$ from the ratio of infrared flux to Lyman continuum flux. Importantly, we show that f \la 0.5 via both methods in many H {\sc ii} regions of the Galaxy. Thus, it establishes that dust in such H {\sc ii} regions absorbs significant amount of Lyman continuum photons directly. To examine the second issue, we approximate $f$ to a function of only the dust-to-gas mass ratio (i.e., metallicity), assuming a parameter fit for the Galactic H {\sc ii} regions. We find that a characteristic $\hat{f}$, which is defined as $f$ averaged over a galaxy-wide scale, is 0.3 for the nearby spiral galaxies. This relatively small $\hat{f}$ indicates that a typical increment factor due to LCE for estimating the global SFR ($1/\hat{f}$) is large ($\sim 3$) for the nearby spiral galaxies. Therefore, we conclude that the effect of LCE is not negligible relative to other uncertainties of estimating the SFR of galaxies.Comment: 18 papges, 11 figures, accepted by Ap

The structure of ESKAPE pathogens isolated from patients of the neonatal intensive care unit at the National Hospital of Pediatrics in Hanoi, the Socialist Republic of Vietnam

Introduction. The incidence of healthcare-associated infections is a major public health problem worldwide, affecting all countries regardless of their economic status. The main agents of these infections are pathogens belonging to the ESKAPE group. The aim of the study was to explore the structure, molecular and antigenic characteristics of the ESKAPE pathogens isolated from oral and anal mucosa of patients of the neonatal intensive care unit (NICU), and to assess their etiological significance in occurrence of healthcare-associated infections. Materials and methods. Samples from a total of 49 children were tested, including 40 newborns patients of NICU at the National Hospital of Pediatrics in Hanoi. Collection and processing of biomaterial (oropharyngeal swabs, rectal swabs) and isolation of bacterial cultures were performed using conventional bacteriological methods. Mass spectrometry was used for identification of isolates. Klebsiella pneumoniae strains were analyzed using the whole-genome sequencing method. Results. The group of gram-positive ESKAPE pathogens identified in oral mucosa was represented by isolates Enterococcus faecium and Staphylococcus aureus. The isolates of the family Enterobacteriaceae included K. pneumoniae, Escherichia coli, Enterobacter cloacae; the group of nonfermenting gram-negative bacteria was represented by Pseudomonas aeruginosa, Acinetobacter baumannii. The structure of ESKAPE pathogens persistent in anal mucosa was characterized by dominance of Enterococcus spp., E. coli, K. pneumoniae and P. aeruginosa bacteria. The whole-genome sequencing of K. pneumoniae isolates revealed 7 clusters and 8 sequence types. ST14 and ST1741 prevailed, accounting for 25%, respectively, of the total number of the studied strains. The molecular serotyping showed that by the O antigen, strains belonged mainly to serotypes O1v1, O1/ O2v2, O5; by the presence of the capsular antigen to serotypes KL2, KL104, KL60. Conclusion. The analysis of the structure of the ESKAPE pathogens isolated from the oral and anal mucosa of patients of NICU at the National Hospital of Pediatrics in Hanoi identified etiologically significant agents of bacterial infections: S. aureus, K. pneumoniae, E. coli, E. cloacae, P. aeruginosa, A. baumannii. The molecular and genetic analysis of K. pneumoniae strains co-circulating in mucous membranes of several patients of the unit revealed their homology, thus confirming healthcare-associated contamination of children with nosocomial strains

Electrophysiology Model for a Human Heart with Ischemic Scar and Realistic Purkinje Network

The role of Purkinje fibres in the onset of arrhythmias is controversial and computer simulations may shed light on possible arrhythmic mechanisms involving the Purkinje fibres. However, few computational modelling studies currently include a detailed Purkinje network as part of the model. We present a coupled Purkinje-myocardium electrophysiology model that includes an explicit model for the ischemic scar plus a detailed Purkinje network, and compare simulated activation times to those obtained by electro-anatomical mapping in vivo during sinus rhythm pacing. The results illustrate the importance of using sufficiently dense Purkinje networks in patient-specific studies to capture correctly the myocardial early activation that may be influenced by surviving Purkinje fibres in the infarct region

ISOPHOT far-infrared serendipity sky survey

The ISOPHOT Serendipity Survey utilizes the slew time between ISO's pointed observations with strip scanning measurements of the sky in the far-IR at 170 micrometers . The slews contain information about two fundamentally different types of objects, namely unresolved galactic and extragalactic far-IR sources as well as extended regions of galactic cirrus emission. Since the structure of the obtained data is almost unique, the development of dedicated software to extract astrophysically interesting parameters for the crossed sources is mandatory. Data analysis is currently in its early stages and concentrates on the detection of point sources. First results from an investigation of a high galactic latitude field near the North Galactic Pole indicate that the detection completeness with respect to previously known IRAS sources will be almost 100 percent for sources with f(subscript 100micrometers > 2 Jy, dropping below approximately equals 50 percent for f(subscript 100micrometers < 1.5 Jy. Nevertheless, even faint sources down to a level of f(subscript 170micrometers approximately equals 1 Jy can be detected. Since the majority of the detected point sources are galaxies, the Serendipity Survey will result in a large database of approximately equals 2000 galaxies

Premature ventricular contractions originating from the left ventricular septum: Results of Radiofrequency Catheter Ablation in twenty patients

<p>Abstract</p> <p>Background</p> <p>RFCA has been established as an effective and curative therapy for severely symptomatic PVC from the outflow tract in structurally normal hearts. However, it is unknown whether PVCs originating from the left ventricular septum, are effectively eliminated by RFCA. This study aimed to investigate electrophysiologic characteristics and effects of Radiofrequency catheter ablation (RFCA) for patients with symptomatic premature ventricular contraction (PVC) originating from the left ventricular septum without including fascicular PVCs.</p> <p>Methods</p> <p>Characteristics of body surface electrocardiogram (ECG) and electrophysiologic recordings endocardiogram in a successful RFCA target were analyzed in 20 patients with symptomatic PVCs originating from the left ventricular septum. RFCA was performed using pace mapping and activation mapping.</p> <p>Results</p> <p>The QRS morphology of PVCs originating from the left ventricular septum is similar to that seen in fascicular tachycardia. Most of the PVCs originated from the left septum appears in the form of ventricular parasystole. The incidence of ventricular parasystole was 70%. Sustained ventricular tachycardia was not inducible by electrical stimulation and isoproterenol infusion in all 20 patients, ablation at the site recording the earliest Purkinje potential was not effective in all 20 patients, and Purkinje potentials were not identified at successful sites during point mapping. Sixteen patients were successful with RFCA using pace mapping and activation mapping, 3 failed, and 1 recurrent.</p> <p>Conclusion</p> <p>Although the ECG characteristics of the PVCs arising from the left ventricular septum are similar to that seen in fascicular tachycardia, the electrophysiologic characteristics are different between the two types of PVCs. The distinguishing characteristic of the PVCs is that Purkinje potentials were not present at the site of successful ablation, suggesting a myocardial as opposed to fascicular substrate. RFCA is an effective curative therapy for symptomatic PVCs originating from the left ventricular septum (not from the left anterior and posterior fascicle).</p

No cold dust within the supernova remnant Cassiopeia A

A large amount (about three solar masses) of cold (18 K) dust in the prototypical type II supernova remnant Cassiopeia A was recently reported. It was concluded that dust production in type II supernovae can explain how the large quantities (10^8 solar masses) of dust observed in the most distant quasars could have been produced within only 700 million years after the Big Bang. Foreground clouds of interstellar material, however, complicate the interpretation of the earlier submillimetre observations of Cas A. Here we report far-infrared and molecular line observations that demonstrate that most of the detected submillimetre emission originates from interstellar dust in a molecular cloud complex located in the line of sight between the Earth and Cas A, and is therefore not associated with the remnant. The argument that type II supernovae produce copious amounts of dust is not supported by the case of Cas A, which previously appeared to provide the best evidence for this possibility.Comment: 13 pages, 3 figure