32 research outputs found

    International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways

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    acutus

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    Symphoricarpos mollis Nutt.Creeping snowberry,  Trailing snowberrySymphoricarpos acutusbeneath firs approx. 1 mi. west of Lake Tahoe at end of Old County Road, 2.3 mi. SW of Cornelian bay,dry soil6500 fee

    The built environment of a medieval castle and outer bailey : Walhain Belgium

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    In the village of Walhain, about 40 km southeast of Brussels, stand the ruins of a feudal fortress attested since the twelfth century. The fortified sector is still dominated by a round tower, the original core of the site; to the south, beyond the now-dry moat, lies the outer bailey area, a flat terrace bordering on the west a marshy stream valley. It was hypothesized that this had been the center of the medieval agricultural estate that archaeological features would be well preserved under the pasture which covers this part of the site today. Initial excavations disclosed a number of features (cobblestone road, stone building foundations), associated on the basis of written records and artifacts with extensive transformations begun around 1500. They also suggested that portions of the terrace were anthropogenic and that buried medieval horizons could be found within them. Excavations in 2003 and 2004 not only revealed important medieval structures in place, but substantiated that much of the terrace was essentially a feat of medieval engineering. A coring program in 2005 provided information on the extent of earthmoving and the internal stratigraphy of the outer bailey terrace, the castle mount and the filled-in moats around them. Subsequent chemical analysis of soil samples taken from key stratigraphic contexts has allowed us to better understand the preconstruction local environment, the history of the initial construction and subsequent transformation of the outer bailey and castle mount, and the differential use intensities of these raised earthen platform

    Computer Aided Improvement of Human-Centered Design Processes

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    With the increasing relevancy of usability as a software quality factor, a growing demand for tools that support the special activities of HCD (human-centered design) processes within the industrial software development community is expected to arise. To elicit initial requirements for tool support, we analyzed the real tasks of developers of four major companies engaged in the development of highly interactive systems, the problems incurred and the burning support issues. Inspired by the results of this survey we developed REUSE, a system that facilitates the elicitation, organization and effective reuse of best practices and artifacts concerning HCD activities and makes their performance more efficient. An initial formative evaluation with future users showed that REUSE is able to improve the utilization of HCD methods within the development process of interactive systems and overcomes some limitations of related approaches
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