Some determinants of organizational success

Organizational efficiency and productivity determined by variables associated with economics, psychology, and sociolog

Bubble memory module

Design, fabrication and test of partially populated prototype recorder using 100 kilobit serial chips is described. Electrical interface, operating modes, and mechanical design of several module configurations are discussed. Fabrication and test of the module demonstrated the practicality of multiplexing resulting in lower power, weight, and volume. This effort resulted in the completion of a module consisting of a fully engineered printed circuit storage board populated with 5 of 8 possible cells and a wire wrapped electronics board. Interface of the module is 16 bits parallel at a maximum of 1.33 megabits per second data rate on either of two interface buses

An X-ray survey of nine historical novae

The Einstein Observatory imaging proportional counter was used to search for X-ray emission from nine nearby historical novae. Six of the novae were detected with estimated X-ray intensities between .1 to 4 keV of 10 to the -13th power to 10 to the -11th power ergs/sq cm-s, comparable to the intensities of previously detected cataclysmic variables. The X-ray intensity of one of the novae, V603 Aql, varies over times of several hundred seconds. The data suggest a correlation between the decay rate of the historical outburst and the current X-ray luminosity. Alternatively, the X-ray luminosity may be related to the inclination of the binary system

Application of Peptides Containing the Cleavage Sequence of Pro-TNFα in Assessing TACE Activity of Whole Cells

Tumor necrosis factor-α (TNFα) is presumably shed from cell membranes by TNFα-cleaving enzyme (TACE). The peptides SPLAQAVRSSSR and Dabcyl-LAQAVRSSSR-Edans, each encompassing the cleavage sequence of pro-TNFα recognized by TACE, were applied to intact umbilical vein endothelium (HUVEC), peripheral blood leukocytes (PBL) and the mast cell line HMC-1, which express TACE, to homogenates of rat heart tissue and to membrane and cytoplasmic extracts of PBL. Formation of SPLAQA (specific cleavage) was determined by HPLC, while cleavage (specific plus non-specific) of Dabcyl-TNFα-Edans was followed over time by measuring fluorescence. Participation of TACE was assessed from inhibition due to the drug TAPI-2. Incubation with recombinant human TACE gave specific cleavage, fully inhibitable by TAPI-2 (IC50<0.1 μM). HUVEC rapidly degraded TNFα-peptide, but in a non-specific manner (no SPLAQA detectable) and 50 μM TAPI-2 was without effect. Fluorescence was evoked when Dabcyl- LAQAVRSSSR-Edans was incubated with HMC-1 or PBL and also with cytoplasmic and membrane fractions of lysed PBL, but in no case was there significant inhibition by TAPI-2. However, marginal (10%) inhibition of fluorescence by 50 μM TAPI-2 was observed with homogenized heart tissue. This contained TACE, about 75% of which was without the inhibitory cysteine switch (Western blot). In conclusion, simple peptide analogs of pro-TNFα cannot be employed as substrates for measuring membrane TACE activity, largely due to extensive non-specific proteolytic cleavage by whole cells and cell extracts

Three-dimensional, transonic rotor flow field reconstructed from holographic interferogram data

Holographic interferometry and computer-assisted tomography (CAT) are used to determine the transonic flow field of a model rotor blade in hover. A pulsed ruby laser records 40 interferograms with a 61 cm-diam view field near the model rotor-blade tip operating at a tip Mach number of 0.90. After digitizing the interferograms and extracting fringe-order functions, the data are transferred to a CAT code. The CAT code then calculates pressure coefficients in several planes above the blade surface. The values from the holography-CAT method compare favorably with previously obtained numerical computations and laser velocimeter measurements at most locations near the blade tip. The results demonstrate the technique's potential for three-dimensional transonic rotor flow studies

Rapid X-ray variability from the Seyfert 1 Galaxy NGC 4051

Strong variable X-ray emission from the nearby low luminosity Seyfert 1 galaxy NGC 4051 was discovered during observations with the imaging proportional counter of the Einstein Observatory. During one 2304 second observation, the X-ray flux more than doubled in an approximately linear fashion, and a 70% increase for 150 seconds was seen during another 968 second observation. Evidence is presented which demonstrates that the X-ray spectrum of NGC 4051 is unusually soft compared to Seyfert 1 galaxies or QSOs. The emission mechanism is probably not synchrotron or synchrotron self-Compton, but the emission can be plausibly explained by various black hole accretion models

Human Capital, Fertility, and Economic Growth

Our model of growth departs from both the Malthusian and neoclassical approaches by including investments in human capital. We assume, crucially, that rates of return on human capital investments rise, rather than, decline, as the stock of human capital increases, until the stock becomes large. This arises because the education sector uses human capital note intensively than either the capital producing sector of the goods producing sector. This produces multiple steady scares: an undeveloped steady stare with little human capital, low rates of return on human capital investments and high fertility, and a developed steady stats with higher rates of return a large, and, perhaps, growing stock of human capital and low fertility. Multiple steady states mean that history and luck are critical determinants of a country's growth experience.