Hepatotoxic effects of low dose oral administration of monosodium glutamate in male albino rats

The present study is aimed at investigating the potentials of low concentration administration of monosodium glutamate in inducing hepatotoxic effects in male albino rats. Thus, monosodiumglutamate at a dose of 5 mg/kg of body weight was administered to adult male albino rats by oral intubation. Treatment was daily for 28 days. The monosodium glutamate treatment significantly (

Low dose oral administration of monosodium glutamate in male albino rats may be nephroprotective

The speculation that low dose intake of monosodium glutamate over time may be toxic warranted the present study. The aim was to investigate the effect of the administration of monosodium glutamate at a low concentration on the functional capacity of the kidney. Thus, monosodium glutamate at a dose of 5 mg/kg of body weight was administered to adult male albino rats by oral intubation. Treatment was daily for 28 days. The monosodium glutamate treatment significantly (p < 0.05) decreased the serum sodium ion concentration by 11.38 % and the water intake by 9.39 %, but had no apparent change in the serum potassium ion concentration (change, 0.00 %). The treatment increased (p < 0.05) the serum urea and creatinine concentration by 12.80 % and 107.81 % respectively. Therefore, treating rats with monosodium glutamate at a low concentration (5 mg/kg of body weight) could be nephroprotective, but with possible significant dehydration. The health implications of the results are highlighted in the discussion

Effect of Aflatoxin B1 - contaminated feed on goat erythrocyte membrane calcium adenosine triphosphatase in vitro

Aflatoxin B1 (AFB1) 2, a food/feed contaminant in the tropics, stimulated the activity of goat erythrocyte membrane ion motive calcium adenosine triphosphatase (Ca-ATPase). The stimulatory action was concentration-dependent, typical of a saturation kinetic effect. The degree of stimulation varied from 20% to more than 90% between the lowest (0.1 M) and highest (1000 M) contentrations. AFB1 induced changes in the apparent kinetic parameters, Km and Vmax, of the erythrocyte membrane-bound enzyme. This could affect erythrocyte structure, and thus, the erythrocyte function in oxygen and delivery to the cells.Keywords: Aflatoxin B1, goat, erythrocyte membrane, Ca-ATPas

EFFECT OF SCOPOLETIN ON ERTHROCYTE MEMBRANE ION MOTIVE ATPASES

The effect of scopoletin, a naturally occurring coumarin in cassava (Manihot esculenta) and its products, on erythroacyte membrane ion motive ATPases was investigated. Sopoletin significantly, stimulated the activities of the ion motive ATPASES (

Effect of processing on the nutrient profiles of Terculia africana decne seed

No Abstract. Discovery and Innovation Vol. 17(1&2) 2005: 14-2