Additional file 1: of Network meta-analyses performed by contracting companies and commissioned by industry

List of eligible contracting companies. The additional file lists eligible contracting companies, whether they were identified via MEDLINE or the ISPOR exhibitors list, and whether they responded to our first survey. (DOC 111 kb

Population differences and the effect of vaginal progesterone on preterm birth in women with threatened preterm labor^*

<p><i>Objective</i>: Threatened preterm labor (tPTL) is a complication of pregnancy. Identification of women and clinical definition differs between countries. This study investigated differences in tPTL and effectiveness of vaginal progesterone to prevent preterm birth (PTB) between two countries.</p> <p><i>Methods</i>: Secondary analysis of a randomized controlled trial (RCT) from Argentina and Switzerland comparing vaginal progesterone to placebo in women with tPTL (<i>n</i> = 379). Cox proportional hazards analysis was performed to compare placebo groups of both countries and to compare progesterone to placebo within each country. We adjusted for baseline differences. Iatrogenic onset of labor or pregnancy beyond gestational age of interest was censored.</p> <p><i>Results</i>: Swiss and Argentinian women were different on baseline. Risks for delivery <14 days and PTB < 34 and < 37 weeks were increased in Argentina compared to Switzerland, HR 3.3 (95% CI 0.62–18), 54 (95% CI 5.1–569) and 3.1 (95% CI 1.1–8.4). In Switzerland, progesterone increased the risk for delivery <14 days [HR 4.4 (95% CI 1.3–15.7)] and PTB <37 weeks [HR 2.5 (95% CI 1.4–4.8)], in Argentina there was no such effect.</p> <p><i>Conclusion</i>: In women with tPTL, the effect of progesterone may vary due to population differences. Differences in populations should be considered in multicenter RCTs.</p

Additional file 2: Table 1. of Pessary or Progesterone to Prevent Preterm delivery in women with short cervical length: the Quadruple P randomised controlled trial

Specification of outcome measures. (PDF 129 kb

Additional file 1: Figure 1. of Pessary or Progesterone to Prevent Preterm delivery in women with short cervical length: the Quadruple P randomised controlled trial

Flow diagram Quadruple P study. (PDF 402 kb

Additional file 2: of A multi-centre, non-inferiority, randomised controlled trial to compare a cervical pessary with a cervical cerclage in the prevention of preterm delivery in women with short cervical length and a history of preterm birth – PC study

SPIRIT checklist for reporting randomised trials for the PC Study. (DOC 120 kb