Effect of the Environment on the Fundamental Plane of Elliptical Galaxies

We present an analysis of interacting E/S0 galaxies location on the Fundamental Plane. Using the NEMO package, we performed N-body simulations of close encounters and mergers between two spherical galaxies. We followed how structural and dynamical parameters (central density, half-mass radius and velocity dispersion)of galaxies are changed during the encounter. We analysed the dependence of these changes on initial mass concentration and presence of dark halo. The results of our simulations are used to discuss the Fundamental Plane for interacting early-type galaxies.Comment: Poster presented at JENAM-2000 (Joint European and National Astronomical meeting - S02. Morphology and dynamics of stellar systems: star clusters, galactic arms and rings

Educational program for osteoporosis patients

Aim: to assess effectiveness of different educational interventions for patients with osteoporosis. Methods: Eighty patients with osteoporosis (95.0% were women) were randomized into the experimental group (n=40) and control group (n=40). The mean age was 62,5±9,0 SD. The patients of experimental group participated in education sessions contained four lessons with interactive methods. The patients of control group got leaflets. Baseline variables were not significantly different between groups. All patients had previously been consulted regarding osteoporosis. Participants were assessed at baseline, 3 months, 6 months and 12 months. The results showed statistically significant increases for knowledge about osteoporosis in the experimental group (63,6%, 64,6%, 65,8% correct answers at 3, 6 and 12 months) compared with control (51,0%, 52,3%, 53,7% correspondingly), p<0,05. Calcium intake was more than 90% in both groups during the study. Recommended pathogenic treatment of osteoporosis was taken by 81,6%, 83,8%, 79,3% patients of the experimental group and 60%, 50%, 54,5% patients of the control group at 3 ,6 and 12 months, p<0,05. Adherence to pathogenetic treatment of osteoporosis was higher in experimental group. Consumption of milk foods was increased at 3 month in both groups and exercises were increased only in experimental group (from 27,5 min. to 112,5 min. in the week), p<0,05. Conclusion: education program for patients with osteoporosis increase adherence to treatment. Education sessions with interactive methods in small groups are more effective, than leaflets.Целью данной работы являлась оценка эффективности различных форм образовательных программ для пациентов с ОП. Материалы и методы: в исследование включено 80 пациентов (95,0% женщин) с первичным ОП. Ср. возраст 62,5±9,0 лет. Все пациенты были случайным образом распределены на две группы. Пациенты основной группы (40 чел.), проходили обучение в небольших группах в течение 4 занятий с использованием интерактивных методов. Контрольная группа (40 чел.) получила информацию в виде брошюры. Исходно группы были сопоставимы по всем изучаемым параметрам. Всем пациентам даны рекомендации по лечению ОП. Оценка проводилась через 3, 6 и 12 мес. Результаты: знания по вопросам ОП были лучше у пациентов основной группы (63.6%, 64,6%, 65,8% правильных ответов через 3,6 и 12 месяцев) по сравнению с контролем (51,0%, 52,3%, 53,7% соответственно), р<0,05. Препараты кальция на протяжении всего исследования принимали более 90% пациентов обеих групп. Число пациентов, принимающих препараты патогенетического действия, в основной группе было больше (81,6%. 83,8%, 79,3% через 3, 6 и 12 мес.) по сравнению с контролем (60%, 50%, 54,5% соответственно), р<0,05. Приверженность приему данных препаратов также была выше в основной группе. Потребление кальция с пищей достоверно возросло у пациентов обеих групп ко второму визиту, а время выполнения упражнений увеличилось только в основной группе (с 27,5 мин. до 112,5 мин. В неделю), р<0,05. Таким образом, образовательные программы по ОП увеличивают приверженность лечению. Обучение пациентов на занятиях в небольших группах с использованием интерактивных методов более эффективно, чем получение информации в виде брошюры

Microwave-Assisted synthesis and evaluation of antibacterial activity of novel 6-fluoroaryl-[1,2,4]triazolo[1,5-A]pyrimidines

A series of 6-fluoroaryl substituted [1,2,4]triazolo[1,5-A]pyrimidines have been synthesized by using the microwave-Assisted Suzuki cross-coupling reaction from readily available 6-bromo-[1,2,4]triazolo[1,5-A]pyrimidine. The antimicrobial activity of new compounds has been evaluated in vitro against Mycobacterium tuberculosis H37Rv and gram-negative (Neisseria gonorrhoeae ATCC 49226) bacteria. © ARKAT-USA, Inc

Mechanism of structural networking in bioactive silicon–zinc–boron-glycerol hydrogel

The aim of this work was the investigation of the gelation mechanism and structural features of Si-Zn-B–gel that provides the high antimicrobial activity.This work was carried out in the framework of the Russian State Assignment (theme № АААА-А19-119011790134-1)

Complex therapy manifest displays a papilloma-virus infection urogenital path

The high appreciation of the complex method in treatment of 36 patients with anogenital warts, using argon laser ablation, combined with system and local immunotherapy of «Panavir» drug is shown. This way of therapy has allowed us to achieve not only the total regression of elements, but also the elimination of human papilloma virus (HPV) of high oncogenic risk.Показана высокая эффективность назначения комплексной терапии остроконечных кондилом аногенитальной области у 36 пациенток с использованием метода аргоноплазменной аблации в сочетании с системной и местной иммунотропной терапией препаратом панавир, которая позволила добиться не только полного регресса высыпаний, но и элиминации ВПЧ высокого онкогенного риска

Principles and methods of diagnostics nonspecific vaginitis

The article presents the comparative characteristics commonly used in diagnosing vaginal infections-ke criteria Amsel (1984), classical techniques ot bacteriology and modern-domain molecular biology techniques (PCR real-time) tor identitication of conditionally pathogenic microorganisms (UTM). We describe a new approach to the study of conditionally pathogenic flora, based on a comprehensive assessment of major groups of microorganisms, form approximating the vaginal biocenosis by PCR in real time. The basis of the diagnostic phase laid the invention, reflecting the clinical and laboratory characteristics of vaginal infections that affect the genital tract of women (patent № 2241990 of 10.12.2004, the patent application, priority of 27.07.2010).В статье представлены данные сравнительной характеристики широко применяемых в диагностике инфекций влагалища критериев Amsel (1984), методов классической бактериологии и современных методов молекулярной биологии (PCR real-time) для идентификации условно-патогенных микроорганизмов (УПМ). Описан принципиально новый подход к исследованию условно-патогенной флоры, основанный на комплексной оценке основных групп микроорганизмов, формирующих вагинальный биоценоз, методом ПЦР в режиме реального времени. В основу диагностического этапа положено изобретение, отражающее клинико-лабораторные характеристики вагинальных инфекций, поражающих половой тракт женщины (патент № 2241990 от 10.12.2004 года, заявка на патент, приоритет от 27.07.2010 года)

N -Acetylcarnosine is a prodrug of L-carnosine in ophthalmic application as antioxidant

Abstract The naturally occurring compound N~-acetylcarnosine (NAC) is proposed as the prodrug of L-carnosine (C) resistant to enzymatic hydrolysis by human serum carnosinase. Rabbit eyes were treated with 1% NAC, C or placebo and extracts of the aqueous humor from the anterior eye chamber were analyzed for imidazole content by reverse phase analytical high performance liquid chromatography (HPLC), thin-layer (TLC) and ion-exchange chromatographic techniques. The topical administration of pure C to the rabbit eye did not lead to accumulation of this compound in the aqueous humor over 30 min in concentration exceeding that in the placebo-treated matched eye. NAC showed dose-dependent hydrolysis in its passage from the cornea to the aqueous humor, releasing C after 15-30 min of ocular administration of prodrug in a series of therapeutical modalities: instillation &lt; subconjunctival injection &lt; ultrasound induced phoresis. Different treatment techniques showed excellent toleration of 1% NAC by the eye. Once in the aqueous humor, C might act as an antioxidant and enter the lens tissue when present at effective concentrations (5-15 mmol/I). The advantage of the ophthalmic prodrug NAC and its bioactivated principle C as universal antioxidants relates to their ability to give efficient protection against oxidative stress both in the lipid phase of biological membranes and in an aqueous environment. NAC is proposed to treat ocular disorders which have the component of oxidative stress in their genesis (cataracts, glaucoma, retinal degeneration, corneal disorders, ocular inflammation, complications of diabetes mellitus, systemic diseases)

Synthesis of novel [1,2,4]triazolo[1,5-b][1,2,4,5]tetrazines and investigation of their fungistatic activity

A series of novel [1,2,4]triazolo[1,5-b][1,2,4,5]tetrazines has been synthesized through oxidation reaction of the corresponding 3,6-disubstituted 1,2,4,5-tetrazines bearing amidine fragments. It is shown that the heterocyclic systems obtained can be modified easily at C(3) position in the reactions with aliphatic alcohols and amines. Also, the reactivity of [1,2,4]triazolo[1,5-b][1,2,4,5]tetrazines towards CH-active compounds has been studied. The obtained triazolo[1,5-b]annulated 1,2,4,5-tetrazines proved to be active in micromolar concentrations in vitro against filamentous anthropophilic and zooanthropophilic dermatophyte fungi (Trichophyton, Microsporum and Epidermofiton), which cause skin and its appendages (hair, nails) diseases. © 2022 Korotina et al.; licensee Beilstein-Institut.Ministry of Education and Science of the Russian Federation, Minobrnauka: 075-15-2020-777; Ural Branch, Russian Academy of Sciences, UB RASThis work was supported by the Ministry of Education and Science of the Russian Federation (Agreement No. 075-15-2020-777).Analytical studies were carried out using equipment of the Center for Joint Use “Spectroscopy and Analysis of Organic Compounds”, located in Postovsky Institute of Organic Synthesis of the Ural Branch of the Russian Academy of Sciences. This work was supported by the Ministry of Education and Science of the Russian Federation (Agreement No. 075-15-2020-777)

Growth of Transition-Metal Dichalcogenides by Solvent Evaporation Technique

Due to their physical properties and potential applications in energy conversion and storage, transition-metal dichalcogenides (TMDs) have garnered substantial interest in recent years. Among this class of materials, TMDs based on molybdenum, tungsten, sulfur, and selenium are particularly attractive due to their semiconducting properties and the availability of bottom-up synthesis techniques. Here we report a method which yields high-quality crystals of transition-metal diselenide and ditelluride compounds (PtTe2, PdTe2, NiTe2, TaTe2, TiTe2, RuTe2, PtSe2, PdSe2, NbSe2, TiSe2, VSe2, ReSe2) from their solid solutions, via vapor deposition from a metal-saturated chalcogen melt. Additionally, we show the synthesis of rare-earth-metal polychalcogenides and NbS2 crystals using the aforementioned process. Most of the crystals obtained have a layered CdI2 structure. We have investigated the physical properties of selected crystals and compared them to state of the art findings reported in the literature. Remarkably, the charge density wave transition in 1T-TiSe2 and 2H-NbSe2 crystals is well-defined at TCDW ≈ 200 and 33 K, respectively. Angle-resolved photoelectron spectroscopy and electron diffraction are used to directly access the electronic and crystal structures of PtTe2 single crystals and yield state of the art measurements. © 2020 American Chemical Society.M.A.-H. acknowledges support from the VR starting grant 2018-05339 and KL1824/6. The crystal growth experiments were supported by the Russian Science Foundation, Project 19-12-00414. The work has been supported by the program 211 of the Russian Federation Government agreements 02.A03.21.0006 and 02.A03.21.0011, by the Russian Government Program of Competitive Growth of Kazan Federal University. We acknowledge MAX IV Laboratory for time on Beamline Bloch under Proposal 20190335. Research conducted at MAX IV, a Swedish national user facility, is supported by the Swedish Research council under contract 2018-07152 the Swedish Governmental Agency for Innovation Systems under contract 2018-04969, and Formas under contract 2019-02496. We acknowledge ARPES experiment support from Craig Polley (MAX IV), Maciej Dendzik (KTH) Antonija Grubisic-Cabo (KTH) and Oscar Tjernberg (KTH). H.R., D.P. and G.J.M. acknowledge the Swedish Research Council (2018-06465, 2018-04330) and the Swedish Energy Agency (P43549-1) for financial support

Image-Subtraction Photometry of the Globular Cluster M3: identification of new double-mode RR Lyrae stars

We have applied the image subtraction method to the M3 dataset previously analyzed by Corwin & Carney (2001; CC01). The new analysis produced light curves and periods for 15 variables, bringing to 222 the total number of RR Lyrae stars in CC01 M3 dataset. We have identified three new candidate double-mode (RRd) variables (V13, V200, and V251) in M3. Of the newly discovered RRd's V13 is unusual in that it has the fundamental as the dominant pulsation mode. Two of the new candidate RRd's (V13 and V200) have period ratios as low as 0.738-0.739. They lie separated from all previously known RRd's in the Petersen diagram, in positions implying a large spread in mass and/or, less likely, in heavy element mass fraction, among the M3 horizontal branch (HB) stars. We explore mass transfer and helium enhancement as possible explanations for the apparent spread in HB masses. We also note that the masses derived from the RRd analyses now favor little mass loss on the red giant branch. V200 has changed its dominant pulsation mode from fundamental to first overtone, while V251 has changed its dominant mode from first overtone to fundamental in the interval 1992 to 1993. Together with M3-V166 this is the first time that RRd variables are observed to switch their dominant pulsation modes while remaining RRd's. The phenomenon is found to occur in a one year time-span thus suggesting that these stars are undergoing a rapid evolutionary phase, and that both redward and blueward evolution may take place among the HB stars in M3. The unusual behavior of the M3 RRd's is discussed and compared to that of the RRd's identified so far in globular clusters and in the field of our and other Local Group galaxies. We find lack of correlation between the presence of RRd variables and any of the cluster structural parameters.Comment: 38 pages, 16 figures, AJ in pres