Selective flow-injection determination of aniline and m-nitroaniline in mixtures containing isomeric nitroanilines and aniline

Operating conditions for the selective flow-injection determination of aniline and 3-nitroaniline in the presence of isomeric nitroanilines as 5,7-dichloro-4,6-benzofuroxan derivatives of test compounds are determined by varying the flow composition. The analytical range is 0.35-17.5 μg/mL for aniline and 1.5-30 μg/mL for 3-nitroaniline. The detection limit of aniline in the presence of nitroanilines is as low as 0.2 μg/mL. © 1998 MAEe cyrillic signK Hayκa/Interperiodica Publishing

Selective flow-injection determination of aniline and m-nitroaniline in mixtures containing isomeric nitroanilines and aniline

Operating conditions for the selective flow-injection determination of aniline and 3-nitroaniline in the presence of isomeric nitroanilines as 5,7-dichloro-4,6-benzofuroxan derivatives of test compounds are determined by varying the flow composition. The analytical range is 0.35-17.5 μg/mL for aniline and 1.5-30 μg/mL for 3-nitroaniline. The detection limit of aniline in the presence of nitroanilines is as low as 0.2 μg/mL. © 1998 MAEe cyrillic signK Hayκa/Interperiodica Publishing

Reversed-phase liquid chromatographic determination of isoniazide in human urine as a test of the genetically predetermined type of biotransformation by acetylation

A new method of determination of genetically predetermined type of biotransformation by acetylation rate using reversed-phase liquid chromatography (RP-HPLC) was described. The method is based on determination of isonicotinic hydrazide (INH) which is excreted with the patient's urine during 24 h period after oral administration of 0.4 g of the drug. INH is used as pharmacogenetic marker. Precolumn derivatization of 4-chloro-5,7- dinitrobenzofurazan is used at RP-HPLC determination of INH and a new drug phosphabenzide (diphenylphosphinylacetic hydrazide, DPPAH) with spectrophotometric detection in urine. The limit of INH detection was 0.27 μg ml-1 and the one of DPPAH was 0.82 μg ml-1. As a result of pharmacokinetic investigation it was discovered that bimodal distribution by acetylation rate for DPPAH is less apparent than in the case of INH. It is shown, that immunomodulator xymedone (N-(β-oxyethyl)-4,6- dimethyldihydropirimidon-2) is the acetylation inductor of xenobiotics

Selective flow-injection determination of aniline and m-nitroaniline in mixtures containing isomeric nitroanilines and aniline

Operating conditions for the selective flow-injection determination of aniline and 3-nitroaniline in the presence of isomeric nitroanilines as 5,7-dichloro-4,6-benzofuroxan derivatives of test compounds are determined by varying the flow composition. The analytical range is 0.35-17.5 μg/mL for aniline and 1.5-30 μg/mL for 3-nitroaniline. The detection limit of aniline in the presence of nitroanilines is as low as 0.2 μg/mL. © 1998 MAEe cyrillic signK Hayκa/Interperiodica Publishing

Selective flow-injection determination of aniline and m-nitroaniline in mixtures containing isomeric nitroanilines and aniline

Operating conditions for the selective flow-injection determination of aniline and 3-nitroaniline in the presence of isomeric nitroanilines as 5,7-dichloro-4,6-benzofuroxan derivatives of test compounds are determined by varying the flow composition. The analytical range is 0.35-17.5 μg/mL for aniline and 1.5-30 μg/mL for 3-nitroaniline. The detection limit of aniline in the presence of nitroanilines is as low as 0.2 μg/mL. © 1998 MAEe cyrillic signK Hayκa/Interperiodica Publishing

Selective flow-injection determination of 1,1-dimetylhydrazine in mixtures

Working conditions are found for the selective flow-injection determination of 1,1-dimetylhydrazine in the presence of some organic and inorganic compounds of different nature (phenol, alkylamines, amino acids, 1,1-hydrazinoacetic acid, aniline, and salts) with a detection limit of 3 × 10-7 M. © 1998 MAEe Cyrillic signK Hayκa/Interperiodica Publishing

La Patrie : journal quotidien, politique, commercial et littéraire

04 mars 19071907/03/04 (A67)

Reversed-phase liquid chromatographic determination of isoniazide in human urine as a test of the genetically predetermined type of biotransformation by acetylation

A new method of determination of genetically predetermined type of biotransformation by acetylation rate using reversed-phase liquid chromatography (RP-HPLC) was described. The method is based on determination of isonicotinic hydrazide (INH) which is excreted with the patient's urine during 24 h period after oral administration of 0.4 g of the drug. INH is used as pharmacogenetic marker. Precolumn derivatization of 4-chloro-5,7- dinitrobenzofurazan is used at RP-HPLC determination of INH and a new drug phosphabenzide (diphenylphosphinylacetic hydrazide, DPPAH) with spectrophotometric detection in urine. The limit of INH detection was 0.27 μg ml-1 and the one of DPPAH was 0.82 μg ml-1. As a result of pharmacokinetic investigation it was discovered that bimodal distribution by acetylation rate for DPPAH is less apparent than in the case of INH. It is shown, that immunomodulator xymedone (N-(β-oxyethyl)-4,6- dimethyldihydropirimidon-2) is the acetylation inductor of xenobiotics

Selective flow-injection determination of 1,1-dimetylhydrazine in mixtures

Working conditions are found for the selective flow-injection determination of 1,1-dimetylhydrazine in the presence of some organic and inorganic compounds of different nature (phenol, alkylamines, amino acids, 1,1-hydrazinoacetic acid, aniline, and salts) with a detection limit of 3 × 10-7 M. © 1998 MAEe Cyrillic signK Hayκa/Interperiodica Publishing

Reversed-phase liquid chromatographic determination of isoniazide in human urine as a test of the genetically predetermined type of biotransformation by acetylation

A new method of determination of genetically predetermined type of biotransformation by acetylation rate using reversed-phase liquid chromatography (RP-HPLC) was described. The method is based on determination of isonicotinic hydrazide (INH) which is excreted with the patient's urine during 24 h period after oral administration of 0.4 g of the drug. INH is used as pharmacogenetic marker. Precolumn derivatization of 4-chloro-5,7- dinitrobenzofurazan is used at RP-HPLC determination of INH and a new drug phosphabenzide (diphenylphosphinylacetic hydrazide, DPPAH) with spectrophotometric detection in urine. The limit of INH detection was 0.27 μg ml-1 and the one of DPPAH was 0.82 μg ml-1. As a result of pharmacokinetic investigation it was discovered that bimodal distribution by acetylation rate for DPPAH is less apparent than in the case of INH. It is shown, that immunomodulator xymedone (N-(β-oxyethyl)-4,6- dimethyldihydropirimidon-2) is the acetylation inductor of xenobiotics