Individual clusters of amygdala activation in pathological gamblers (corrected p<0.001).

<p>The coordinates are taken from the MNI Brain Atlas. The origin of the coordinates refers to the anterior commissure.</p

phMRI of Yohimbine.

<p><b>Top: Yohimbine Infusion Procedure.</b> Following a 5 min baseline, yohimbine was infused in four separate infusions, each infusion lasting 20 sec, and with an interinfusion interval of 2 min, as shown in the box (see Text). <b>Middle: Plasma levels of Yohimbine.</b> Based on prior reports <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0031118#pone.0031118-Guthrie1" target="_blank">[77]</a> doses of yohimbine reach maximal levels immediately after intravenous infusion and remain high for at least 20 min. <b>Bottom:</b> Plasma levels of norepinephrine rapidly follow yohimbine infusions <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0031118#pone.0031118-Guthrie2" target="_blank">[78]</a>. These levels also remain high for the duration of the phMRI data acquisition.</p

Group medians and mean (±SDs) for the performance indices on the Copy Figure, Detection and Recognition of an Object and the Road Map tests.

<p>Group medians and mean (±SDs) for the performance indices on the Copy Figure, Detection and Recognition of an Object and the Road Map tests.</p

Detection and Recognition of an Object Test (DROT).

<p>“High noise” and “low noise” sets were presented separately, with the latter following the former. Subjects were instructed to identify the object embedded in the noise.</p

The Money Road Map Test (RMT).

<p>The continuous dotted line represents the path followed by the researcher's pen. Subjects were asked at each successive turn to indicate whether it was right or left. The smaller dotted line in the lower right serves as a practice trial.</p

The two-dimensional (diamond and cross) and three-dimensional (Necker cube, smoking pipe, hidden line elimination cube, pyramid and dissected pyramid) figures copied by the subjects (Panel A). Examples of PG subjects' performance on the Copy Figure Test (Panel B).

<p>The two-dimensional (diamond and cross) and three-dimensional (Necker cube, smoking pipe, hidden line elimination cube, pyramid and dissected pyramid) figures copied by the subjects (Panel A). Examples of PG subjects' performance on the Copy Figure Test (Panel B).</p