Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Fasteners made easy, 2019

Guide containing instructions for constructing various types of fasteners in clothing. Revised May 2019

Fashion Forecasting

How do retailers decide which colors and styles are featured in their stores? What factors influence the patterns, textiles and silhouettes designers show in their collections? These choices are all made with the help of fashion forecasting-a dynamic industry that identifies the trends that influence what people will be wearing in the future. This text provides students with a comprehensive understanding of the forecasting process, from studying fashion innovation and cultural influences to conducting consumer research, exploring how to identify the who, what, where, when and why driving fashion change in our lives. New co-author Divita has revised the structure of each chapter to streamline content and improve the flow of information while discussing timely examples and industry applications. Ultimately, students will learn how to prepare and present their own fashion forecast. Features - Includes 150 color photographs showing current examples - Industry Pro les illustrate the types of job opportunities that exist for students and ground theoretical concepts in real-world application - End-of-chapter summaries, activities, and discussion questions engage students in creative application of concepts New to this Edition - New Chapter 5, “Popular Culture and Forecasting”, connects the influence of television, music, movies and social media to the rise of trends - Thoroughly updated Chapter 4, now entitled “Modern Forecasting Methods”, features current forecasters such as Trend Tablet, Perclers Paris, and Nelly Rodi Lab - New You Be The Forecaster feature allows students to apply the skills in each chapter in scenarios that simulate real-world career situations Fashion Forecasting STUDIO - Study smarter with self-quizzes featuring scored results and personalized study tips - Review concepts with flashcards of essential vocabulary - Watch videos that bring chapter concepts to life Teaching Resources - Instructor\u27s Guide with Test Bank provides suggestions for planning the course and using the text in the classroom, supplemental assignments, lecture notes, and sample test questions. - PowerPoint® presentations include images from the book and provide a framework for lecture and discussio