Estimates of serotype-specific contributions to IPD in children (%, 95%CI) reported are based on random effects model from meta-analysis of 3 or more studies, unless indicated [one study (*) or two (**)].

<p>Estimates of serotype-specific contributions to IPD in children (%, 95%CI) reported are based on random effects model from meta-analysis of 3 or more studies, unless indicated [one study (*) or two (**)].</p

Main characteristics of studies included in the review and meta-analyses.

<p>Main characteristics of studies included in the review and meta-analyses.</p

Serotype-specific contributions (%) to paediatric IPD cases by region in studies with PCV7 implementation.

<p>Serotype-specific contributions (%) to paediatric IPD cases by region in studies with PCV7 implementation.</p

Serotype-specific contributions (%) to paediatric IPD cases in settings that have introduced PCV10 or PCV13.

<p>Serotype-specific contributions (%) to paediatric IPD cases in settings that have introduced PCV10 or PCV13.</p

PRISMA flowchart—Literature review process.

<p>PRISMA flowchart—Literature review process.</p

Anemonopsis macrophylla Sieb. et Zucc.

原著和名: レンゲショウマ科名: キンポウゲ科 = Ranunculaceae採集地: 神奈川県 丹沢山 (相模 丹沢山)採集日: 1962/8/31採集者: 萩庭丈壽整理番号: JH001868国立科学博物館整理番号: TNS-VS-95186

Effect of TNF-α neutralizing antibody on thermal sensitivity

<p>qPCR: The data are cycle threshold (CT) values of beta2m (reference) and TNF-alpha.</p> <p>Neutrophil counts: Neutrophils were counted in the plantar region from heel to the toes, in 10 separate sections (fields of view) at 1000x. Total number of neutrophils equals the sum of neutrophils in all 10 sections.</p> <p>Myeloperoxidase activity: The data show optical density (OD) readings at 450nm and "BA" values = OD - average of the blanks. Average "BA" values per gram of tissue weight = MPO activity as OD/gm of wet tissue.</p> <p>Mast cell degranulation: The data show numbers and percentages of intact and mildly, moderately, extensively degranulated mast cells in the hind paw tissue.</p> <p>Hyperalgesia: "BL Latency" signifies baseline latency values in seconds and "Delta latency" signifies change in thermal latency (experimental average - baseline average) at each time point for each mouse.</p> <p>Edema: "BL R" and "BL L" = baseline paw width in mm for the right and left hindpaw of each mouse respectively. Baseline values are subtracted from averages of left (L) and right (R) paw widths at each time point to give the delta paw width at each time point.</p> <p>ELISA: The data show the concentrations of TNF-alpha protein in hind paw tissue lysate assayed in duplicate and the average concentration in pg/ml of paw lysate.</p> <p> </p

A Newton Algorithm for the Nearest Correlation Matrix

Firstly, we describe and investigate the algorithm of Qi and Sun which solves the problem of finding the nearest correlation matrix to a symmetric matrix. This algorithm claims a quadratic convergence. We discuss improving this algorithm's efficiency and reliability and detect a problem when we are aiming at a nearest correlation matrix with a high accuracy, using small error tolerences. As a consequence, we suggest a modified version, based on the algorithm of Qi and Sun, which is also a quadratically convergent algorithm, has improved efficiency and is modified so that the algorithm can return the nearest correlation matrix to high accuracy showing a robust and reliable behaviour. Secondly, we investigate the general alternating projections method and also Higham's alternating projections method for the nearest correlation matrix. We discuss variations of the latter and include a further projection which allows more constraints to be added to the problem. We introduce a new algorithm and compare its convergence behaviour with Higham's alternating projections method