Gender and age-matched case control study of a cohort of adrenal adenomas

Background: The majority of adrenal incidentalomas are benign and patients can be reassured, but a personalized and multidisciplinary approach is required when dealing with these lesions, since they might be linked with various comorbidities. The aim of our study was to carry out an in-depth analysis of the biochemical workup of adrenal incidentalomas and comparing the results with controls. Methods: 252 patients with an incidentally discovered adrenal adenoma were identified. A retrospective cross-sectional analysis of this cohort was carried out. A corresponding cohort of 252 gender and aged-matched patients (+/- 5 years) who underwent a CT scan for a similar indication and on the same day as the cases was recruited. A comparison of numerous parameters was carried out.peer-reviewe

An analysis of blood parameter changes in Cushing's syndrome - a population-based study

Aim: Glucocorticoids play a significant role in inflammation and immune system disruption. Our study aimed to analyse different biochemical and blood count indices and serum inflammationbased scores in patients with all different causes of endogenous Cushing’s Syndrome (CS) in a welldefined population.Methods: Clinical records of 35 patients diagnosed with CS between 2008 and 2020 at the only central national health service hospital in Malta, were retrospectively analysed. Detailed clinical and biochemical data were obtained for each patient. Correlation and receiver operator characteristics (ROC) curve analyses were used to establish a threshold value for different variables to predict malignant CS.peer-reviewe