Epidemiology and population dynamics of HRSV in São Paulo.

<p>Bayesian skyline plots of HRSV genotypes prevalent in São Paulo (top) and seasonal distribution of HRSV cases in São Paulo during the 1995–2005 seasons are shown in the <i>x</i>-axis. GA1, GA3 GA7 and GB4 were excluded from the BSL analysis because of small sample size (n<10). The <i>y</i>-axis (on the left) represents a measure of relative genetic diversity presented as <i>Ne.g</i> reflecting the change in effective number of infections over time; where <i>g</i> is the average generation time. The <i>y</i>-axis (on the right) represents the number of samples in the study. (-) - Number of total samples collected during the period. (-) - Number of all HRSV positive cases identified with monoclonal antibodies and molecular characterization.</p

Population dynamics and genetic diversity of HRSV.

<p>A) Bayesian skyline plots of HRSVA genotypes B) Bayesian skyline plots of HRSVB genotypes. Positively selected amino acid substitution sites are represented as previously described by Botosso et al. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0041953#pone.0041953-Botosso1" target="_blank">[48]</a>. The <i>y</i>-axis represents a measure of relative genetic diversity presented as <i>Ne.g</i> reflecting the change in effective number of infections over time.</p

Global demographic history of HRSV genotypes.

<p>Bayesian skyline plots of complete HRSV sequences of HRSVA (n = 1203) and HRSVB (n = 780). The <i>y</i>-axis represents a measure of relative genetic diversity presented as <i>Ne.g</i> reflecting the change in effective population (a surrogate for number of infections) over time for the complete set of HRSV sequences for HRSVA (n = 1204) and HRSVB (n = 778). The dotted lines define the likelihood bounds corresponding to a 95% confidence interval (CI). (…) - Upper and lower limits for HRSVA; (—) - Upper and lower limits for HRSVB. The arrow represents a shift in dynamics between HRSVA and HRSVB.</p