First proof of concept of remote attendance for future observation strategies between Wettzell (Germany) and Concepción (Chile)

Current VLBI observations are controlled and attended locally at the radio telescopes on the basis of pre-scheduled session files. Operations have to deal with system specific station commands and individual setup procedures. Neither the scheduler nor the correlator nor the data-analyst gets real-time feedback about system parameters during a session. Changes in schedules after the start of a session by remote are impossible or at least quite difficult. For future scientific approaches, a more flexible mechanism would optimize the usage of resources at the sites. Therefore shared-observation control between world-wide telescope s, remote attendance/control as well as completely unattended-observations could be useful, in addition to the classic way to run VLBI observations. To reach these goals, the Geodetic Observatory Wettzell in cooperation with the Max-Planck-Institute for Radio Astronomy (Bonn) have developed a software extension to the existing NASA Field System for remote control. It uses the principle of a remotely accessible, autonomous process cell as server extension to the Field System on the basis of Remote Procedure Calls (RPC). Based on this technology the first completely remote attended and controlled geodetic VLBI session between Wettzell, Germany and Concepción, Chile was successfully performed over 24 hours. This first test was extremely valuable for gathering information about the differences between VLBI systems and measuring the performance of internet connections and automatic connection re-establishments. During the 24h-session, the network load, the number of sent/received packages and the transfer speed were monitor ed and captured. It was a first reliable test for the future wishes to control several telescopes with one graphical user interface on different data transfer rates over large distances in an efficient way. In addition, future developments for an authentication and user role management will be realized within the upcoming NEXPReS project

Application of time-dependent density functional theory to optical activity

As part of a general study of the time-dependent local density approximation (TDLDA), we here report calculations of optical activity of chiral molecules. The theory automatically satisfies sum rules and the Kramers-Kronig relation between circular dichroism and optical rotatory power. We find that the theory describes the measured circular dichroism of the lowest states in methyloxirane with an accuracy of about a factor of two. In the chiral fullerene C_76 the TDLDA provides a consistent description of the optical absorption spectrum, the circular dichroism spectrum, and the optical rotatory power, except for an overall shift of the theoretical spectrum.Comment: 17 pages and 13 PostScript figure

Quality of life with talazoparib after platinum or multiple cytotoxic non-platinum regimens in patients with advanced breast cancer and germline BRCA1/2 mutations: patient-reported outcomes from the ABRAZO phase 2 trial.

Background Talazoparib (1 mg/day) exhibited promising efficacy and safety in patients with advanced breast cancer during ABRAZO (NCT02034916); this study evaluated patient-reported outcomes (PROs).Patients and methods ABRAZO is a two-cohort, two-stage, phase 2 study of talazoparib in patients with advanced breast cancer after a response to prior platinum-based therapy (cohort 1 [C1], n = 49) or ≥3 platinum-free cytotoxic-based regimens (cohort 2 [C2], n = 35). PROs were assessed on day 1 (baseline), every 6 weeks for an initial 24 weeks, and every 12 weeks thereafter until progression, using the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 (QLQ-C30) and its breast cancer module, QLQ-BR23.Results Global health status/quality of life (GHS/QoL) was maintained from baseline across all time points for both C1 and C2. For C1 and C2, median time to deterioration (TTD) of GHS/QoL (95% confidence interval [CI]) was 2.8 (2.1, 3.0) and 5.5 (4.2, 5.7) months, respectively. Median TTD for all QLQ-C30 functional scales for C1 and C2 ranged 2.1-3.1 months and 4.2-5.6 months, respectively; median TTD for all QLQ-BR23 symptom scales ranged 2.6-4.0 months and 4.2-5.6 months, respectively. There were no statistically significant differences in estimated overall change from baseline in the GHS/QoL scale for both cohorts (C1: -2.6 [95% CI, -7.8, 2.5]; C2: 1.2 [95% CI, -5.5, 8.0]). Significant overall improvements in the breast symptoms and arm symptoms and the future perspective of patients in C1 and C2 were observed, despite the statistically significant and clinically meaningful overall deterioration among patients regarding their role functioning (in C1) and dyspnoea symptoms (in C2).Conclusion Despite the statistically significant and clinically meaningful overall deterioration among patients regarding their role functioning (in C1) and dyspnoea symptoms (in C2), patients in both C1 and C2 reported significant overall improvements in their breast symptoms, arm symptoms and future perspective, and their GHS/QoL was maintained from baseline