4 research outputs found

    Additional file 1 of Oropharyngeal and intestinal concentrations of opportunistic pathogens are independently associated with death of SARS-CoV-2 critically ill adults

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    Additional file 1: Table S1. Result of the initial 16S rDNA sequencing in rectal samples. Table S2. Per pathogen rectal and oropharyngeal culture positivity, time to first positivity and abundance at first positivity. Table S3. Adjusted impact of abundance of Enterococcus spp., S. aureus and Candida spp. in oropharynx and rectum on day 90 mortality. (one adjusted model for each). Table S4. Univariate analysis of day 90 mortality* comparing survivors versus descedents. Fig S1. Quantitative culturing on agar plates. CFU: colony-forming unit. Fig S2. Pie chart of the distribution of Enterococcus spp. and Candida spp. species obtained by culture of all the rectal swabs (A) and oropharyngeal (B) swabs. Fig S3. Dot plots of the intestinal Enterococcus spp. and Candida spp. with regards to intestinal richness (genus level), Shannon and inverse Simpson indices. The Pearson correlation test was used (with the intestinal concentrations being considered as continuous variables)

    Additional file 6: of In-depth resistome analysis by targeted metagenomics

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    MGC abundance comparison of biocide resistance between swine and human samples. Gene abundance was extracted from original count data after normalization. Some sets of genes make complex MGCs. In this representation, MGC quantification was discarded in order to increase the biological information. Genes were classified by compound susceptibility. Because some biocide resistance genes can confer different phenotypes (resistance to more than one compound), genes are not constricted to one category. Genetic abundance is expressed as reads per kilobase per million reads (RPKM). The right panel shows the results of MSS and the left panel shows the results of ResCap. (PDF 933 kb
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