Factors associated with the bias.

<p>(CI: confidence interval. SBP: systolic blood pressure. DBP: diastolic blood pressure. HR: heart rate. SpO2: pulse-oximeter saturation. Hb-Lab: hemoglobin value obtained invasively. PI: perfusion index. VAS: visual analogical scale).</p

Flow chart of the studies (Pronto-7™ on panel A and Orsense on panel B).

<p>Flow chart of the studies (Pronto-7™ on panel A and Orsense on panel B).</p

Concordance parameters of the two methods.

<p>(ICC: intra-class correlation. CI: confidence interval).</p

Association between perfusion index and bias.

<p>Results for the Pronto-Study are displayed on the panel A and for the Orsense-Study on the panel B. The red line represents the linear regression relationship between the perfusion index and the bias. Perfusion index is linearly correlated with the bias in Orsense-Study but not in the Pronto-Study (Spearman correlation coefficients at - 0.06, p = 0.36 and 0.42, p<0.0001 for the Pronto-Study and Orsense-study, respectively).</p

Three-dimensional representation of the variability of the measures obtained with the two monitors.

<p>Results for the Pronto-Study are displayed on the panel A and for the Orsense-Study on the panel B. The coordinates of each point are the three consecutive measures. The graphical representation shows that the Orsense™ monitor seems to be associated with a higher variability compared to the Pronto-7™. This is confirmed by the fact that variations among the three consecutive measurements was lower than 2.5% in 71% of the cases when using the Pronto-7™ monitor but only in 47% of the cases when using the Orsense™ monitor</p

Distribution of hemoglobin value in the two populations studied.

<p>As depicted in the figure, the overlap of hemoglobin values between the two populations studied is almost complete all along the range of hemoglobin values.</p

Bland and Altman graphical representation of the concordance between the laboratory value of hemoglobin and SpHb.

<p>Results for the Pronto-Study are displayed on the panel A and for the Orsense-Study on the panel B. The plain horizontal blue line represents the mean bias and the dashed horizontal blue lines represent the upper and the lower limits of agreement.</p

Association between true values of hemoglobin and bias.

<p>Results for the Pronto-Study are displayed on the panel A and for the Orsense-Study on the panel B. The red line represents the linear regression relationship between the true value of hemoglobin and the bias. There is an inverse correlation between hemoglobin and bias in both studies (Spearman correlation coefficients at - 0.51, p <0.0001 and -0.37, p<0.0001 for the Pronto-Study and the Orsense-study, respectively).</p

Additional file 3: of Reversal of neutrophil-to-lymphocyte count ratio in early versus late death from septic shock

Table S3. Neutrophils, lymphocytes counts and NLCR variations according to the septic origin ( abdominal vs extra-abdominal) and death timing. (DOC 21 kb

Additional file 1: Table S1. of Reversal of neutrophil-to-lymphocyte count ratio in early versus late death from septic shock

p Values of the two-way ANOVA comparing cellular counts over time between survivors and nonsurvivors. (DOC 21 kb