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Correction to “Design, Synthesis, and Structure–Activity Relationship of a Novel Series of GluN2C-Selective Potentiators”
Design, Synthesis, and Structure–Activity Relationship of a Novel Series of GluN2C-Selective Potentiators
NMDA
receptors are tetrameric complexes composed of GluN1 and GluN2A–D
subunits that mediate a slow Ca<sup>2+</sup><b>-</b>permeable
component of excitatory synaptic transmission. NMDA receptors have
been implicated in a wide range of neurological diseases and thus
represent an important therapeutic target. We herein describe a novel
series of pyrrolidinones that selectively potentiate only NMDA receptors
that contain the GluN2C subunit. The most active analogues tested
were over 100-fold selective for recombinant GluN2C-containing receptors
over GluN2A/B/D-containing NMDA receptors as well as AMPA and kainate
receptors. This series represents the first class of allosteric potentiators
that are selective for diheteromeric GluN2C-containing NMDA receptors