6 research outputs found
Additional file 1: of The potential role of infectious agents and pelvic inflammatory disease in ovarian carcinogenesis
Systematic literature search. (DOCX 37 kb
Breast and ovarian cancer genotype specific risks for each tSNP by study
<p>1 odds ratio, 2 confidence interval, * compared with common homozygote. Confidence intervals that do not reach or cross 1.00 and P- values<0.05 are in bold type</p
Linkage disequilibrium between the 92 common variants (MAF>0.05) in HapMap CEPH trios.
<p>Each square represents the correlation (r<sup>2</sup>) between each pair of SNPs with darker shades representing stronger LD. Tag SNPs are indicated with those SNPs that failed assay design being shown in grey font.</p
Serous type ovarian cancer genotype specific risks for each tSNP
*<p>compared with common homozygote. Confidence intervals that do not reach or cross 1.00 and P- values<0.05 are in bold type</p
Top SNPs associated with SER EOC across racial groups.
<p><sup>1</sup> MAF, minor allele and its frequency</p><p><sup>2</sup> p-value <0.05 are in bold</p><p><sup>3</sup> Odds ratio, 95% confidence interval</p><p>Top SNPs associated with SER EOC across racial groups.</p
The most significant SNPs in the transport pathway genes and risk of EOC by histology, invasiveness, and race/ethnicity<sup>1</sup>.
<p><sup>1</sup> INV: all invasive EOC combined; LMP: low malignant potential / borderline tumors; SER: serous; CC: clear cell; End: endometrioid; Muc: mucinous. Statistically significant associations are indicated in bold (P<0.05). Data format is the following: OR (95% CI); p-value; FDR q-value (white-European women). Only significant FDRs (q<0.2) are shown (<i>HEPH</i>: INV and SER<i>; UGT1A</i>: End).</p><p>The most significant SNPs in the transport pathway genes and risk of EOC by histology, invasiveness, and race/ethnicity<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0128106#t001fn001" target="_blank"><sup>1</sup></a>.</p