69 research outputs found

    Celebrating 20 Years of the ExCEEd Teaching Workshop

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    In response to the clear need for faculty training, the American Society of Civil Engineers (ASCE) developed and funded Project ExCEEd (Excellence in Civil Engineering Education) which is celebrating its twentieth year of existence. For the past two decades, 38 ExCEEd Teaching Workshops (ETW) have been held at six different universities. The program has 910 graduates from over 267 different U.S. and international colleges and universities. The ExCEEd effort has transformed from one that relied on the grass roots support of its participants to one that is supported and embraced by department heads and deans. This paper summarizes the history of Project ExCEEd, describes the content of the ETW, assesses its effectiveness, highlights changes in the program as a result of the assessment, and outlines the future direction of the program

    A Novel CCR5 Mutation Common in Sooty Mangabeys Reveals SIVsmm Infection of CCR5-Null Natural Hosts and Efficient Alternative Coreceptor Use In Vivo

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    In contrast to HIV infection in humans and SIV in macaques, SIV infection of natural hosts including sooty mangabeys (SM) is non-pathogenic despite robust virus replication. We identified a novel SM CCR5 allele containing a two base pair deletion (Δ2) encoding a truncated molecule that is not expressed on the cell surface and does not support SIV entry in vitro. The allele was present at a 26% frequency in a large SM colony, along with 3% for a CCR5Δ24 deletion allele that also abrogates surface expression. Overall, 8% of animals were homozygous for defective CCR5 alleles and 41% were heterozygous. The mutant allele was also present in wild SM in West Africa. CD8+ and CD4+ T cells displayed a gradient of CCR5 expression across genotype groups, which was highly significant for CD8+ cells. Remarkably, the prevalence of natural SIVsmm infection was not significantly different in animals lacking functional CCR5 compared to heterozygous and homozygous wild-type animals. Furthermore, animals lacking functional CCR5 had robust plasma viral loads, which were only modestly lower than wild-type animals. SIVsmm primary isolates infected both homozygous mutant and wild-type PBMC in a CCR5-independent manner in vitro, and Envs from both CCR5-null and wild-type infected animals used CXCR6, GPR15 and GPR1 in addition to CCR5 in transfected cells. These data clearly indicate that SIVsmm relies on CCR5-independent entry pathways in SM that are homozygous for defective CCR5 alleles and, while the extent of alternative coreceptor use in SM with CCR5 wild type alleles is uncertain, strongly suggest that SIVsmm tropism and host cell targeting in vivo is defined by the distribution and use of alternative entry pathways in addition to CCR5. SIVsmm entry through alternative pathways in vivo raises the possibility of novel CCR5-negative target cells that may be more expendable than CCR5+ cells and enable the virus to replicate efficiently without causing disease in the face of extremely restricted CCR5 expression seen in SM and several other natural host species

    Rationale and design: telepsychology service delivery for depressed elderly veterans

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    <p>Abstract</p> <p>Background</p> <p>Older adults who live in rural areas experience significant disparities in health status and access to mental health care. "Telepsychology," (also referred to as "telepsychiatry," or "telemental health") represents a potential strategy towards addressing this longstanding problem. Older adults may benefit from telepsychology due to its: (1) utility to address existing problematic access to care for rural residents; (2) capacity to reduce stigma associated with traditional mental health care; and (3) utility to overcome significant age-related problems in ambulation and transportation. Moreover, preliminary evidence indicates that telepsychiatry programs are often less expensive for patients, and reduce travel time, travel costs, and time off from work. Thus, telepsychology may provide a cost-efficient solution to access-to-care problems in rural areas.</p> <p>Methods</p> <p>We describe an ongoing four-year prospective, randomized clinical trial comparing the effectiveness of an empirically supported treatment for major depressive disorder, Behavioral Activation, delivered either via in-home videoconferencing technology ("Telepsychology") or traditional face-to-face services ("Same-Room"). Our hypothesis is that in-homeTelepsychology service delivery will be equally effective as the traditional mode (Same-Room). Two-hundred twenty-four (224) male and female elderly participants will be administered protocol-driven individual Behavioral Activation therapy for depression over an 8-week period; and subjects will be followed for 12-months to ascertain longer-term effects of the treatment on three outcomes domains: (1) clinical outcomes (symptom severity, social functioning); (2) process variables (patient satisfaction, treatment credibility, attendance, adherence, dropout); and (3) economic outcomes (cost and resource use).</p> <p>Discussion</p> <p>Results from the proposed study will provide important insight into whether telepsychology service delivery is as effective as the traditional mode of service delivery, defined in terms of clinical, process, and economic outcomes, for elderly patients with depression residing in rural areas without adequate access to mental health services.</p> <p>Trial registration</p> <p>National Institutes of Health Clinical Trials Registry (ClinicalTrials.gov identifier# NCT00324701).</p

    On Target: 2006 Annual Summary of Field Crop Insect Management Trials

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    Since its inception in 1984, the University of Illinois Insect Management and Insecticide Evaluation Program has provided the producers of Illinois complete and informative evaluations of registered insecticides and new chemical and transgenic tools for the management of insect pests in Illinois. It is our intention to provide scientifically sound efficacy data to aid the producers of Illinois in their insect pest management decision making.University of Illinois Extension and Department of Crop Science

    On Target: 2005 Annual Summary of Field Crop Insect Management Trials

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    Since its inception in 1984, the University of Illinois Insect Management and Insecticide Evaluation Program has provided the producers of Illinois complete and informative evaluations of registered insecticides and new chemical and transgenic tools for the management of insect pests in Illinois. It is our intention to provide scientifically sound efficacy data to aid the producers of Illinois in their insect pest management decision making.University of Illinois Extension and Department of Crop Science

    Evaluation of a seed-blend (Pioneer Optimum AcreMax) to control corn rootworm larvae (Diabrotica spp.) in Illinois, 2008

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    Annual summary of field crop insect management trials, Department of Crop Services, University of Illinois. Providing accurate and unbiased evaluations of insect control products and management strategies to assist growers in Illinois.University of Illinois Extension and Department of Crop Science

    Evaluation of Force 2.25CS to control corn rootworm larvae (Diabrotica spp.) in Illinois, 2008

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    Annual summary of field crop insect management trials, Department of Crop Services, University of Illinois. Providing accurate and unbiased evaluations of insect control products and management strategies to assist growers in Illinois.University of Illinois Extension and Department of Crop Science

    Comparison of experimental and commercially available granular insecticides to control corn rootworm larvae (Diabrotica spp.) in Illinois, 2008

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    Annual summary of field crop insect management trials, Department of Crop Services, University of Illinois. Providing accurate and unbiased evaluations of insect control products and management strategies to assist growers in Illinois.University of Illinois Extension and Department of Crop Science
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