978 research outputs found
scattering S wave from the data on the reaction
The results of the recent experiments on the reaction
performed at KEK, BNL, IHEP, and CERN are analyzed in detail. For the I=0
S wave phase shift and inelasticity a new set
of data is obtained. Difficulties emerging when using the physical solutions
for the S and D wave amplitudes extracted with the partial wave
analyses are discussed. Attention is drawn to the fact that, for the
invariant mass, m, above 1 GeV, the other solutions, in principle,
are found to be more preferred. For clarifying the situation and further
studying the resonance thorough experimental investigations of the
reaction in the m region near the threshold
are required.Comment: 17 pages, 5 figure
Symmetry breaking during homodimeric assembly activates an E3 ubiquitin ligase
Citation: Ye, Z., Needham, P. G., Estabrooks, S. K., Whitaker, S. K., Garcia, B. L., Misra, S., . . . Camacho, C. J. (2017). Symmetry breaking during homodimeric assembly activates an E3 ubiquitin ligase. Scientific Reports, 7(1). doi:10.1038/s41598-017-01880-4C-terminus of Hsc/p70-Interacting Protein (CHIP) is a homodimeric E3 ubiquitin ligase.Each CHIP monomer consists of a tetratricopeptide-repeat (TPR), helix-turn-helix (HH), and U-box domain.In contrast to nearly all homodimeric proteins, CHIP is asymmetric.To uncover the origins of asymmetry, we performed molecular dynamics simulations of dimer assembly.We determined that a CHIP monomer is most stable when the HH domain has an extended helix that supports intra-monomer TPR-U-box interaction, blocking the E2-binding surface of the U-box.We also discovered that monomers first dimerize symmetrically through their HH domains, which then triggers U-box dimerization.This brings the extended helices into close proximity, including a repulsive stretch of positively charged residues.Unable to smoothly unwind, this conflict bends the helices until the helix of one protomer breaks to relieve the repulsion.The abrupt snapping of the helix forces the C-terminal residues of the other protomer to disrupt that protomer's TPR-U-box tight binding interface, swiftly exposing and activating one of the E2 binding sites.Mutagenesis and biochemical experiments confirm that C-terminal residues are necessary both to maintain CHIP stability and function.This novel mechanism indicates how a ubiquitin ligase maintains an inactive monomeric form that rapidly activates only after asymmetric assembly. © 2017 The Author(s)
Interventions aimed at increasing research use in nursing: a systematic review
<p>Abstract</p> <p>Background</p> <p>There has been considerable interest recently in developing and evaluating interventions to increase research use by clinicians. However, most work has focused on medical practices; and nursing is not well represented in existing systematic reviews. The purpose of this article is to report findings from a systematic review of interventions aimed at increasing research use in nursing.</p> <p>Objective</p> <p>To assess the evidence on interventions aimed at increasing research use in nursing.</p> <p>Methods</p> <p>A systematic review of research use in nursing was conducted using databases (Medline, CINAHL, Healthstar, ERIC, Cochrane Central Register of Controlled Trials, and Psychinfo), grey literature, ancestry searching (Cochrane Database of Systematic Reviews), key informants, and manual searching of journals. Randomized controlled trials and controlled before- and after-studies were included if they included nurses, if the intervention was explicitly aimed at increasing research use or evidence-based practice, and if there was an explicit outcome to research use. Methodological quality was assessed using pre-existing tools. Data on interventions and outcomes were extracted and categorized using a pre-established taxonomy.</p> <p>Results</p> <p>Over 8,000 titles were screened. Three randomized controlled trials and one controlled before- and after-study met the inclusion criteria. The methodological quality of included studies was generally low. Three investigators evaluated single interventions. The most common intervention was education. Investigators measured research use using a combination of surveys (three studies) and compliance with guidelines (one study). Researcher-led educational meetings were ineffective in two studies. Educational meetings led by a local opinion leader (one study) and the formation of multidisciplinary committees (one study) were both effective at increasing research use.</p> <p>Conclusion</p> <p>Little is known about how to increase research use in nursing, and the evidence to support or refute specific interventions is inconclusive. To advance the field, we recommend that investigators: (1) use theoretically informed interventions to increase research use, (2) measure research use longitudinally using theoretically informed and psychometrically sound measures of research use, as well as, measuring patient outcomes relevant to the intervention, and (3) use more robust and methodologically sound study designs to evaluate interventions. If investigators aim to establish a link between using research and improved patient outcomes they must first identify those interventions that are effective at increasing research use.</p
Assessment of variation in the alberta context tool: the contribution of unit level contextual factors and specialty in Canadian pediatric acute care settings
Background: There are few validated measures of organizational context and none that we located are
parsimonious and address modifiable characteristics of context. The Alberta Context Tool (ACT) was developed to
meet this need. The instrument assesses 8 dimensions of context, which comprise 10 concepts. The purpose of
this paper is to report evidence to further the validity argument for ACT. The specific objectives of this paper are
to: (1) examine the extent to which the 10 ACT concepts discriminate between patient care units and (2) identify
variables that significantly contribute to between-unit variation for each of the 10 concepts.
Methods: 859 professional nurses (844 valid responses) working in medical, surgical and critical care units of 8
Canadian pediatric hospitals completed the ACT. A random intercept, fixed effects hierarchical linear modeling
(HLM) strategy was used to quantify and explain variance in the 10 ACT concepts to establish the ACT’s ability to
discriminate between units. We ran 40 models (a series of 4 models for each of the 10 concepts) in which we
systematically assessed the unique contribution (i.e., error variance reduction) of different variables to between-unit
variation. First, we constructed a null model in which we quantified the variance overall, in each of the concepts.
Then we controlled for the contribution of individual level variables (Model 1). In Model 2, we assessed the
contribution of practice specialty (medical, surgical, critical care) to variation since it was central to construction of
the sampling frame for the study. Finally, we assessed the contribution of additional unit level variables (Model 3).
Results: The null model (unadjusted baseline HLM model) established that there was significant variation between
units in each of the 10 ACT concepts (i.e., discrimination between units). When we controlled for individual
characteristics, significant variation in the 10 concepts remained. Assessment of the contribution of specialty to
between-unit variation enabled us to explain more variance (1.19% to 16.73%) in 6 of the 10 ACT concepts. Finally,
when we assessed the unique contribution of the unit level variables available to us, we were able to explain
additional variance (15.91% to 73.25%) in 7 of the 10 ACT concepts.
Conclusion: The findings reported here represent the third published argument for validity of the ACT and adds
to the evidence supporting its use to discriminate patient care units by all 10 contextual factors. We found
evidence of relationships between a variety of individual and unit-level variables that explained much of this
between-unit variation for each of the 10 ACT concepts. Future research will include examination of the
relationships between the ACT’s contextual factors and research utilization by nurses and ultimately the
relationships between context, research utilization, and outcomes for patients
I=3/2 Scattering in the Nonrelativisitic Quark Potential Model
We study elastic scattering to Born order using
nonrelativistic quark wavefunctions in a constituent-exchange model. This
channel is ideal for the study of nonresonant meson-meson scattering amplitudes
since s-channel resonances do not contribute significantly. Standard quark
model parameters yield good agreement with the measured S- and P-wave phase
shifts and with PCAC calculations of the scattering length. The P-wave phase
shift is especially interesting because it is nonzero solely due to
symmetry breaking effects, and is found to be in good agreement with experiment
given conventional values for the strange and nonstrange constituent quark
masses.Comment: 12 pages + 2 postscript figures, Revtex, MIT-CTP-210
To what extent do nurses use research in clinical practice? A systematic review
Background : In the past forty years, many gains have been made in our understanding of the concept of research utilization. While numerous studies exist on professional nurses\u27 use of research in practice, no attempt has been made to systematically evaluate and synthesize this body of literature with respect to the extent to which nurses use research in their clinical practice. The objective of this study was to systematically identify and analyze the available evidence related to the extent to which nurses use research findings in practice. Methods : This study was a systematic review of published and grey literature. The search strategy included 13 online bibliographic databases: Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, MEDLINE, CINAHL, EMBASE, HAPI, Web of Science, SCOPUS, OCLC Papers First, OCLC WorldCat, ABI Inform, Sociological Abstracts, and Dissertation Abstracts. The inclusion criteria consisted of primary research reports that assess professional nurses\u27 use of research in practice, written in the English or Scandinavian languages. Extent of research use was determined by assigning research use scores reported in each article to one of four quartiles: low, moderate-low, moderate-high, or high. Results : Following removal of duplicate citations, a total of 12,418 titles were identified through database searches, of which 133 articles were retrieved. Of the articles retrieved, 55 satisfied the inclusion criteria. The 55 final reports included cross-sectional/survey (n = 51) and quasi-experimental (n = 4) designs. A sensitivity analysis, comparing findings from all reports with those rated moderate (moderate-weak and moderate-strong) and strong quality, did not show significant differences. In a majority of the articles identified (n = 38, 69%), nurses reported moderate-high research use. Conclusions : According to this review, nurses\u27 reported use of research is moderate-high and has remained relatively consistent over time until the early 2000\u27s. This finding, however, may paint an overly optimistic picture of the extent to which nurses use research in their practice given the methodological problems inherent in the majority of studies. There is a clear need for the development of standard measures of research use and robust well-designed studies examining nurses\u27 use of research and its impact on patient outcomes. The relatively unchanged self-reports of moderate-high research use by nurses is troubling given that over 40 years have elapsed since the first studies in this review were conducted and the increasing emphasis in the past 15 years on evidence-based practice. More troubling is the absence of studies in which attempts are made to assess the effects of varying levels of research use on patient outcomes.<br /
Exploring the role of organizational policies and procedures in promoting research utilization in registered nurses
<p>Abstract</p> <p>Background</p> <p>Policies and procedures (P&Ps) have been suggested as one possible strategy for moving research evidence into practice among nursing staff in hospitals. Research in the area of P&Ps is limited, however. This paper explores: 1) nurses' use of eight specific research-based practices (RBPs) and RBP overall, 2) nurses' use and understanding of P&Ps, and 3) the role of P&Ps in promoting research utilization.</p> <p>Methods</p> <p>Staff nurses from the eight health regions governing acute care services across the Canadian province of Newfoundland and Labrador completed an anonymous questionnaire regarding their use of eight RBPs and associated P&Ps. Data were also obtained from authorities in six of the eight regions about existing relevant P&Ps. We used descriptive statistics and multivariate regression analysis to assess the relationship between key independent variables and self-reported use of RBP.</p> <p>Results</p> <p>Use of the eight RBPs ranged from 7.8% to 88.6%, depending on the practice. Nurses ranked P&P manuals as their number one source of practice knowledge. Most respondents (84.8%) reported that the main reason they consult the P&P manual is to confirm they are practicing according to agency rules. Multivariate regression analysis identified three significant predictors of being a user versus non-user of RBP overall: awareness, awareness by regular use, and persuasion. Six significant predictors of being a consistent versus less consistent user of RBP overall were also identified: perception of P&P existence, unit, nursing experience, personal experience as a source of practice knowledge, number of existing research-based P&Ps, and lack of time as a barrier to consulting P&P manuals.</p> <p>Conclusion</p> <p>Findings suggest that nurses use P&Ps to guide their practice. However, the mere existence of P&Ps is not sufficient to translate research into nursing practice. Individual and organizational factors related to nurses' understanding and use of P&Ps also play key roles. Thus, moving research evidence into practice will require careful interplay between the organization and the individual. P&Ps may be the interface through which this occurs.</p
Determination of hadronic partial widths for scalar-isoscalar resonances f0(980), f0(1300), f0(1500), f_0(1750) and the broad state f0(1530^{+90}_{-250})
In the article of V.V. Anisovich et al., Yad. Fiz. 63, 1489 (2000), the
K-matrix solutions for the wave IJ^{PC}=00^{++} were obtained in the mass
region 450 - 1900 MeV where four resonances f0(980), f0(1300), f0(1500),
f0(1750) and the broad state f0(1530^{+90}_{-250}) are located. Based on these
solutions, we determine partial widths for scalar-isoscalar states decaying
into the channels pi-pi, K-anti K, eta-eta, eta-eta', pi-pi-pi-pi and
corresponding decay couplings.Comment: Some typos were correcte
On the precision of the theoretical predictions for pi pi scattering
In a recent paper, Pelaez and Yndurain evaluate some of the low energy
observables of pi pi scattering and obtain flat disagreement with our earlier
results. The authors work with unsubtracted dispersion relations, so that their
results are very sensitive to the poorly known high energy behaviour of the
scattering amplitude. They claim that the asymptotic representation we used is
incorrect and propose an alternative one. We repeat their calculations on the
basis of the standard, subtracted fixed-t dispersion relations, using their
asymptotics. The outcome fully confirms our earlier findings. Moreover, we show
that the Regge parametrization proposed by these authors for the region above
1.4 GeV violates crossing symmetry: Their ansatz is not consistent with the
behaviour observed at low energies.Comment: Added more material, mostly in Sects. 7, 8 and 9, in support of the
same conclusions. Latex, 28 pages, 3 figure
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