An overall strategy based on regression models to estimate relative survival and model the effects of prognostic factors in cancer survival studies.

Relative survival provides a measure of the proportion of patients dying from the disease under study without requiring the knowledge of the cause of death. We propose an overall strategy based on regression models to estimate the relative survival and model the effects of potential prognostic factors. The baseline hazard was modelled until 10 years follow-up using parametric continuous functions. Six models including cubic regression splines were considered and the Akaike Information Criterion was used to select the final model. This approach yielded smooth and reliable estimates of mortality hazard and allowed us to deal with sparse data taking into account all the available information. Splines were also used to model simultaneously non-linear effects of continuous covariates and time-dependent hazard ratios. This led to a graphical representation of the hazard ratio that can be useful for clinical interpretation. Estimates of these models were obtained by likelihood maximization. We showed that these estimates could be also obtained using standard algorithms for Poisson regression

Controlled splitting of an atomic wave packet

We propose a simple scheme capable of adiabatically splitting an atomic wave packet using two independent translating traps. Implemented with optical dipole traps, our scheme allows a high degree of flexibility for atom interferometry arrangements and highlights its potential as an efficient and high fidelity atom optical beam splitter.Comment: 4 pages, 4 figures. Accepted by Phys. Rev. Let

Cavity-based single atom preparation and high-fidelity hyperfine state readout

We prepare and detect the hyperfine state of a single 87Rb atom coupled to a fiber-based high finesse cavity on an atom chip. The atom is extracted from a Bose-Einstein condensate and trapped at the maximum of the cavity field, resulting in a reproducibly strong atom-cavity coupling. We use the cavity reflection and transmission signal to infer the atomic hyperfine state with a fidelity exceeding 99.92% in a read-out time of 100 microseconds. The atom is still trapped after detection.Comment: 5 pages, 4 figure

Spin squeezing, entanglement and quantum metrology with Bose-Einstein condensates

Squeezed states, a special kind of entangled states, are known as a useful resource for quantum metrology. In interferometric sensors they allow to overcome the "classical" projection noise limit stemming from the independent nature of the individual photons or atoms within the interferometer. Motivated by the potential impact on metrology as wells as by fundamental questions in the context of entanglement, a lot of theoretical and experimental effort has been made to study squeezed states. The first squeezed states useful for quantum enhanced metrology have been proposed and generated in quantum optics, where the squeezed variables are the coherences of the light field. In this tutorial we focus on spin squeezing in atomic systems. We give an introduction to its concepts and discuss its generation in Bose-Einstein condensates. We discuss in detail the experimental requirements necessary for the generation and direct detection of coherent spin squeezing. Two exemplary experiments demonstrating adiabatically prepared spin squeezing based on motional degrees of freedom and diabatically realized spin squeezing based on internal hyperfine degrees of freedom are discussed.Comment: Phd tutorial, 23 pages, 17 figure

Is neuroblastoma screening evaluation needed and feasible?

Despite the five million children who have been screened for neuroblastoma in Japan through detection of catecholamine metabolites, it is still uncertain whether screening for this disease is beneficial. The Japanese study has clearly indicated that screening at 6 months or earlier leads to heavy overdiagnosis. It is shown in this paper that screening at a later age may give the same reduction in mortality with possibly less overdiagnosis. However, it is estimated that, even with two screens at 12 and 18 months, the reduction in mortality would not greatly exceed 25%, under realistic hypotheses on the length of the preclinical phase of the disease. The evaluation of the efficacy of this screening strategy would need the recruitment of half a million children per year over 5-7 years and the follow-up of an equal number of controls. Such a trial would improve our knowledge of the natural history of the disease and might help to answer some questions raised recently regarding its biological heterogeneity

Nonlinear atom interferometer surpasses classical precision limit

Interference is fundamental to wave dynamics and quantum mechanics. The quantum wave properties of particles are exploited in metrology using atom interferometers, allowing for high-precision inertia measurements [1, 2]. Furthermore, the state-of-the-art time standard is based on an interferometric technique known as Ramsey spectroscopy. However, the precision of an interferometer is limited by classical statistics owing to the finite number of atoms used to deduce the quantity of interest [3]. Here we show experimentally that the classical precision limit can be surpassed using nonlinear atom interferometry with a Bose-Einstein condensate. Controlled interactions between the atoms lead to non-classical entangled states within the interferometer; this represents an alternative approach to the use of non-classical input states [4-8]. Extending quantum interferometry [9] to the regime of large atom number, we find that phase sensitivity is enhanced by 15 per cent relative to that in an ideal classical measurement. Our nonlinear atomic beam splitter follows the "one-axis-twisting" scheme [10] and implements interaction control using a narrow Feshbach resonance. We perform noise tomography of the quantum state within the interferometer and detect coherent spin squeezing with a squeezing factor of -8.2dB [11-15]. The results provide information on the many-particle quantum state, and imply the entanglement of 170 atoms [16]

Andreev bound states in high-TcT_c superconducting junctions

The formation of bound states at surfaces of materials with an energy gap in the bulk electron spectrum is a well known physical phenomenon. At superconductor surfaces, quasiparticles with energies inside the superconducting gap $\Delta$ may be trapped in bound states in quantum wells, formed by total reflection against the vacuum and total Andreev reflection against the superconductor. Since an electron reflects as a hole and sends a Cooper pair into the superconductor, the surface states give rise to resonant transport of quasiparticle and Cooper pair currents, and may be observed in tunneling spectra. In superconducting junctions, these surface states may hybridize and form bound Andreev states, trapped between the superconducting electrodes. In d-wave superconductors, the order parameter changes sign under $90^o$ rotation and, as a consequence, Andreev reflection may lead to the formation of zero energy quasiparticle bound states, midgap states (MGS). The formation of MGS is a robust feature of d-wave superconductivity and provides a unified framework for many important effects which will be reviewed: large Josephson current, low-temperature anomaly of the critical Josephson current, $\pi$-junction behavior, $0\to \pi$ junction crossover with temperature, zero-bias conductance peaks, paramagnetic currents, time reversal symmetry breaking, spontaneous interface currents, and resonance features in subgap currents. Taken together these effects, when observed in experiments, provide proof for d-wave superconductivity in the cuprates.Comment: 52 pages, 20 figures. Review article under consideration for publication in Superconductor Science and Technolog