7 research outputs found
A Burkholderia pseudomallei toxin inhibits helicase activity of translation factor eIF4A
The structure of BPSL1549, a protein of unknown function from Burkholderia pseudomallei, reveals a similarity to Escherichia coli cytotoxic necrotizing factor 1. We found that BPSL1549 acted as a potent cytotoxin against eukaryotic cells and was lethal when administered to mice. Expression levels of bpsl1549 correlate with conditions expected to promote or suppress pathogenicity. BPSL1549 promotes deamidation of glutamine-339 of the translation initiation factor eIF4A, abolishing its helicase activity and inhibiting translation. We propose to name BPSL1549 Burkholderia lethal factor 1
A land of milk and money The discursive construction of Monsanto's Posilac
SIGLEAvailable from British Library Document Supply Centre-DSC:3812.0152(no 15) / BLDSC - British Library Document Supply CentreGBUnited Kingdo