The influence of stress on substrate utilization in skeletal muscle fibres of reindeer (Rangifer tarandus L)

Moderate stress in connection with handling, sampling and herding of reindeer caused a very pronounced depletion of glycogen in mainly type IIA and IIB fibres. Also intramuscular triglyceride levels decreased but mainly in type I fibres. Muscle lactate levéls increased in all animals but not to the levels found in pigs exposed to stress or exertion. Reindeer muscles appeared to have a great capacity to oxidize both carbohydrates and lipids. All animals showed increased Cortisol, urea and AS AT values. A marked depletion of glycogen and lipids in many of the fibres may be a factor involved in the development of skeletal muscle degeneration in connection with mental stress and exertion as there seems to be a correlation between high ASAT values and substrate depleted musclefibres. A connection may therefore exist between high instramuscular substrate stores and the ability of a muscle to tolerate stress.Av stress påverkat substratutnyttjande i skelettmuskelfibrer hos renAbstract in Swedish / Sammanfattning: Måttlig stress betingad av hantering, provtagning och drivning av ren orsakade en mycket kraftig minskning av muskelglykogen i fråmst typ IIA och typ IIB fibrer. Aven triglycerider minskade framfor allt i typ I fibrer. Muskellaktatnivåerna okade i samtliga undersokta djur, men inte till nivåer som ses hos gris utsatta for stress eller fysisk anstrångning.Renens muskler uppvisade en mycket hog kapacitet att oxidera, forbranna, både kolhydrat och fett. Alla djur uppvisade forhojda Cortisol, urea och ASAT varden. Den mycket kraftiga tomningen av kolhydrat och fett i många muskelfibrer kan vara en faktor medverkande till muskeldegeneration i samband med mental stress och anstrangning då hoga ASAT-vården synes vara korrelerade till uttomda muskelfibrer. Ett samband mellan hog instramuskulår substratupplagring och formåga att tåla stress kan således foreligga.Stressin vaikuttaneen poron substraattihyvåk-sikåytto luurangon lihaksiston kuiduissa.Abstract in Finnish / Yhteenveto: Kohtuullinen stressi edellyttåen kåsittelyå, kokeenottoa ja poronajoa aiheutti hyvin voimakkaan lihasglykogeenin våhentymisen etenkin II A ja II B tyyppisisså fiibereisså. Myoskin triglyseriidit våhentyivåt kaikissa tutkituissa elåimissa, muttei kuitenkaan niihin tasoihin asti kuin sijoissa, jotka ovat joutuneet alttiiksi stressiin tai fyysilliseen rasitukseen. porojen lihakset osoittivat hyvin korkeaa kapasiteettia sekå hiilihydraatin ettå rasvan palamiseen. Kaikki elåimet osoittivat kohonnutta cortisoolin, urean ja ASATin arvoa. Hyvin voimakas hiilihydraatin ja rasvan tyhjentyminen monissa lihaskuiduissa voi olla vaikutin lihasrappeutumiseen henkisen stressin ja rasituksen yhteydesså, jolloin korkea ASAT-arvo nåyttåå olevan vastaavuussuhteessa tyhjentyneisiin lihaskuituihin. Lihaksiston korkean substraattivarastoimisin ja stressin sietokyvyn suhde voi siis olla olemassa

The exact Darwin Lagrangian

Darwin (1920) noted that when radiation can be neglected it should be possible to eliminate the radiation degrees-of-freedom from the action of classical electrodynamics and keep the discrete particle degrees-of-freedom only. Darwin derived his well known Lagrangian by series expansion in $v/c$ keeping terms up to order $(v/c)^2$. Since radiation is due to acceleration the assumption of low speed should not be necessary. A Lagrangian is suggested that neglects radiation without assuming low speed. It cures deficiencies of the Darwin Lagrangian in the ultra-relativistic regime.Comment: 2.5 pages, no figure

The comfortable roller coaster -- on the shape of tracks with constant normal force

A particle that moves along a smooth track in a vertical plane is influenced by two forces: gravity and normal force. The force experienced by roller coaster riders is the normal force, so a natural question to ask is: what shape of the track gives a normal force of constant magnitude? Here we solve this problem. It turns out that the solution is related to the Kepler problem; the trajectories in velocity space are conic sections.Comment: 10 pages, 4 figure

On the regular-geometric-figure solution to the N-body problem

The regular-geometric-figure solution to the $N$-body problem is presented in a very simple way. The Newtonian formalism is used without resorting to a more involved rotating coordinate system. Those configurations occur for other kinds of interactions beyond the gravitational ones for some special values of the parameters of the forces. For the harmonic oscillator, in particular, it is shown that the $N$-body problem is reduced to $N$ one-body problems.Comment: To appear in Eur. J. Phys. (5 pages

Mechanics, cosmology and Mach's principle

It is pointed out that recent cosmological findings seem to support the view that the mass/energy distribution of the universe defines the Newtonian inertial frames as originally suggested by Mach. The background concepts of inertial frame, Newton's second law, and fictitious forces are clarified. A precise definition of Mach's principle is suggested. Then an approximation to general relativity discovered by Einstein, Infeld, and Hoffmann is used and it is found that this precise formulation of Mach's principle is realized provided the mass/energy density of the universe has a specific value. This value turns out to be twice the critical density. The implications of this approximate result is put into context.Comment: 9 pages, 34 references, 0 figure

From least action in electrodynamics to magnetomechanical energy -- a review

The equations of motion for electromechanical systems are traced back to the fundamental Lagrangian of particles and electromagnetic fields, via the Darwin Lagrangian. When dissipative forces can be neglected the systems are conservative and one can study them in a Hamiltonian formalism. The central concepts of generalized capacitance and inductance coefficients are introduced and explained. The problem of gauge independence of self-inductance is considered. Our main interest is in magnetomechanics, i.e. the study of systems where there is exchange between mechanical and magnetic energy. This throws light on the concept of magnetic energy, which according to the literature has confusing and peculiar properties. We apply the theory to a few simple examples: the extension of a circular current loop, the force between parallel wires, interacting circular current loops, and the rail gun. These show that the Hamiltonian, phase space, form of magnetic energy has the usual property that an equilibrium configuration corresponds to an energy minimum.Comment: 29 pages, 9 figures, 65 reference

Repeated post-exercise administration with a mixture of leucine and glucose alters the plasma amino acid profile in Standardbred trotters

<p>Abstract</p> <p>Background</p> <p>The branched chain amino acid leucine is a potent stimulator of insulin secretion. Used in combination with glucose it can increase the insulin response and the post exercise re-synthesis of glycogen in man. Decreased plasma amino acid concentrations have been reported after intravenous or per oral administration of leucine in man as well as after a single per oral dose in horses. In man, a negative correlation between the insulin response and the concentrations of isoleucine, valine and methionine have been shown but results from horses are lacking. This study aims to determine the effect of repeated per oral administration with a mixture of glucose and leucine on the free amino acid profile and the insulin response in horses after glycogen-depleting exercise.</p> <p>Methods</p> <p>In a crossover design, after a glycogen depleting exercise, twelve Standardbred trotters received either repeated oral boluses of glucose, 1 g/kg body weight (BW) at 0, 2 and 4 h with addition of leucine 0.1 g/kg BW at 0 and 4 h (GLU+LEU), or repeated boluses of water at 0, 2 and 4 h (CON). Blood samples for analysis of glucose, insulin and amino acid concentrations were collected prior to exercise and over a 6 h post-exercise period. A mixed model approach was used for the statistical analyses.</p> <p>Results</p> <p>Plasma leucine, isoleucine, valine, tyrosine and phenylalanine concentrations increased after exercise. Post-exercise serum glucose and plasma insulin response were significantly higher in the GLU+LEU treatment compared to the CON treatment. Plasma leucine concentrations increased after supplementation. During the post-exercise period isoleucine, valine and methionine concentrations decreased in both treatments but were significantly lower in the GLU+LEU treatment. There was no correlation between the insulin response and the response in plasma leucine, isoleucine, valine and methionine.</p> <p>Conclusions</p> <p>Repeated post-exercise administration with a mixture of leucine and glucose caused a marked insulin response and altered the plasma amino acid profile in horses in a similar manner as described in man. However, the decreases seen in plasma amino acids in horses seem to be related more to an effect of leucine and not to the insulin response as seen in man.</p

Maternal care and birth outcomes among ethnic minority women in Finland

<p>Abstract</p> <p>Background</p> <p>Care during pregnancy and labour is of great importance in every culture. Studies show that people of migrant origin have barriers to obtaining accessible and good quality care compared to people in the host society. The aim of this study is to compare the access to and use of maternity services, and their outcomes among ethnic minority women having a singleton birth in Finland.</p> <p>Methods</p> <p>The study is based on data from the Finnish Medical Birth Register in 1999–2001 linked with the information of Statistics Finland on woman's country of birth, citizenship and mother tongue. Our study data included 6,532 women of foreign origin (3.9% of all singletons) giving singleton birth in Finland during 1999–2001 (compared to 158,469 Finnish origin singletons).</p> <p>Results</p> <p>Most women have migrated during the last fifteen years, mainly from Russia, Baltic countries, Somalia and East Europe. Migrant origin women participated substantially in prenatal care. Interventions performed or needed during pregnancy and childbirth varied between ethnic groups. Women of African and Somali origin had most health problems resulted in the highest perinatal mortality rates. Women from East Europe, the Middle East, North Africa and Somalia had a significant risk of low birth weight and small for gestational age newborns. Most premature newborns were found among women from the Middle East, North Africa and South Asia. Primiparous women from Africa, Somalia and Latin America and Caribbean had most caesarean sections while newborns of Latin American origin had more interventions after birth.</p> <p>Conclusion</p> <p>Despite good general coverage of maternal care among migrant origin women, there were clear variations in the type of treatment given to them or needed by them. African origin women had the most health problems during pregnancy and childbirth and the worst perinatal outcomes indicating the urgent need of targeted preventive and special care. These study results do not confirm either healthy migrant effect or epidemiological paradox according to which migrant origin women have considerable good birth outcomes.</p

Social differentiation and embodied dispositions: a qualitative study of maternal care-seeking behaviour for near-miss morbidity in Bolivia

<p>Abstract</p> <p>Background</p> <p>Use of maternal health care in low-income countries has been associated with several socioeconomic and demographic factors, although contextual analyses of the latter have been few. A previous study showed that 75% of women with severe obstetric morbidity (near-miss) identified at hospitals in La Paz, Bolivia were in critical conditions upon arrival, underscoring the significance of pre-hospital barriers also in this setting with free and accessible maternal health care. The present study explores how health care-seeking behaviour for near-miss morbidity is conditioned in La Paz, Bolivia.</p> <p>Methods</p> <p>Thematic interviews with 30 women with a near-miss event upon arrival at hospital. Near-miss was defined based on clinical and management criteria. Modified analytic induction was applied in the analysis that was further influenced by theoretical views that care-seeking behaviour is formed by predisposing characteristics, enabling factors, and perceived need, as well as by socially shaped habitual behaviours.</p> <p>Results</p> <p>The self-perception of being fundamentally separated from "others", meaning those who utilise health care, was typical for women who customarily delivered at home and who delayed seeking medical assistance for obstetric emergencies. Other explanations given by these women were distrust of authority, mistreatment by staff, such as not being kept informed about their condition or the course of their treatment, all of which reinforced their dissociation from the health-care system.</p> <p>Conclusion</p> <p>The findings illustrate health care-seeking behaviour as a practise that is substantially conditioned by social differentiation. Social marginalization and the role health institutions play in shaping care-seeking behaviour have been de-emphasised by focusing solely on endogenous cultural factors in Bolivia.</p