34 research outputs found
Dura mater-associated Creutzfeldt-Jakob disease:experience from surveillance in the UK
Between 1970 and 2003, seven cases of human dura materāassociated CreutzfeldtāJakob disease (CJD) were identified in the UK. Furthermore, we identified a case of CJD in a porcine dura graft recipient. The mean incubation period of the human dura mater cases was 93 (range 45ā177)ā
months. The clinicoāpathological features of the cases are described and compared with cases previously reported in the world literature
Review of multidimensional data processing approaches for Raman and infrared spectroscopy
Greutzfeldt-Jakob-Erkrankung (CJK) bzw. humane Ć¼bertragbare (transmissible) spongiforme Enzephalopathien (TSE)
Anticoagulant Use and Bleeding Risk in Central European Patients with Idiopathic Pulmonary Fibrosis (IPF) Treated with Antifibrotic Therapy: Real-World Data from EMPIRE
The connection betweenĀ perceived constructivist learning environments and faculty uncivil authoritarian behaviors
Low-content quantification in powders using Raman spectroscopy: a facile chemometric approach to sub 0.1% limits of detection.
A robust and accurate analytical methodology for low-content (<0.1%) quantification in the
solid-state using Raman spectroscopy, sub-sampling, and chemometrics was demonstrated using
a piracetamāproline model. The method involved a 5-step process: collection of relatively large
number of spectra (8410) from each sample by Raman mapping, meticulous data pretreatment to
remove spectral artefacts, use of a 0ā100% concentration range partial least squares (PLS)
regression model to estimate concentration at each pixel, use of a more-accurate, reduced
concentration range PLS model to accurately calculate analyte concentration at each pixel, and
finally statistical analysis of all 8000+ concentration predictions to produce an accurate overall
sample concentration. The relative prediction accuracy was ~2.4% for a 0.05~1.0%
concentration range and the limit of detection was comparable to high performance liquid
chromatography (0.03% versus 0.041%). For data pretreatment, we developed a unique cosmic
ray removal method and used an automated baseline correction method, neither of which
required subjective user intervention and thus were fully automatable. The method is applicable
to systems, which cannot be easily analyzed chromatographically such as hydrate, polymorph, or
solvate contamination.Research undertaken as part of the Synthesis and Solid State Pharmaceutical Centre, funded
by Science Foundation Ireland and industry partners, and Enterprise Ireland (Grant No: TC-
2012-5106).2016-02-2