Improved survival prediction and comparison of prognostic models for patients with hepatocellular carcinoma treated with sorafenib

Background: The ‘Prediction Of Survival in Advanced Sorafenib-treated HCC’ (PROSASH) model addressed the heterogeneous survival of patients with hepatocellular carcinoma (HCC) treated with sorafenib in clinical trials but requires validation in daily clinical practice. This study aimed to validate, compare and optimize this model for survival prediction. Methods: Patients treated with sorafenib for HCC at five tertiary European centres were retrospectively staged according to the PROSASH model. In addition, the optimized PROSASH-II model was developed using the data of four centres (training set) and tested in an independent dataset. These models for overall survival (OS) were then compared with existing prognostic models. Results: The PROSASH model was validated in 445 patients, showing clear differences between the four risk groups (OS 16.9-4.6 months). A total of 920 patients (n = 615 in training set, n = 305 in validation set) were available to develop PROSASH-II. This optimized model incorporated fewer and less subjective parameters: the serum albumin, bilirubin and alpha-foetoprotein, and macrovascul

The ever-growing complexity of the data retention discussion in the EU: An in-depth review of La Quadrature du Net and others and Privacy International

The data retention discussion in the EU is becoming ever more complex. In La Quadrature du Net and others and Privacy International, the CJEU applied its data retention standards to a wide variety of new facts, including data retention, transmission, and automated analysis, both for law enforcement and national security goals. Moreover, the CJEU identified a diverse range of situations in which EU law permits data retention and similar measures on a general and indiscriminate basis. The two judgments provide new opportunities for large scale data retention but raise novel questions about the scope of EU law over national security issues, and the CJEU’s reasoning is too brief in some respects

User Perspectives on the News Personalisation Process: Agency, Trust and Utility as Building Blocks

With the increasing use of algorithms in news distribution, commentators warn about its possible impacts on the changing relationship between the news media and news readers. To understand the meaning of news personalisation strategies to users, we investigated how they currently experience news personalisation, perceive their role in the personalisation process, and envision increasing the utility of personalised news by giving users more agency and fostering trust. We conducted four focus groups with online news readers in Germany. For the analysis, grounded theory techniques were suitable due to their applicability in reconstructing user perspectives through their own experiences. We found that (1) users fail to distinguish between news personalisation and commercial targeting, which may negatively bias their perception; (2) there is a contradiction in how users perceive themselves as active participants in the process, but lack the means to exercise agency; (3) user concerns extend beyond privacy to what information they receive and their right to personal autonomy—a solution requires offering users the ability to dynamically adjust their “news interest profiles”; (4) while news personalisation strategies afford new opportunities for introducing reciprocity in the media-audience relationship, negotiating competing logics of journalistic, personal and algorithmic curation remains a challenge