Effects of weight and length of Barbus grypus broodstock on fingerlings production and growth

The effects of weight and length of Barbus grypus broodstock on fingerlings reproductive characteristics and growth were investigated. We chose three female treatments including weight and length groups (1) 2212.5±479g, 62.68±6.7cm, (2) 4518±780g, 79.12±4.36cm and (3) 7712.5±1171g, 92.62±3.13cm. The same male broodstock were used for all the treatments with the weight and length size of 1400±100g, 54.62±7.35cm. Female broodstock were injected 3mg/kg PG hormone two times at an interval of 10 hours. Males were injected 2mg/kg once at the time females received their second injection. Larvae and fingerling survival rate and growth indices (special growth coefficient, condition factor) up to the fingerling stage were calculated for all treatments of larvae culture. Fingerling stage in ponds, 02, pH, temperature, transparency, nitrate, and phosphate were measured and no significant difference was observed (P>0.05) among the ponds. The special growth rate, condition factor, and fingerling survival of the treatments showed no significant differences (P>0.05). However, our results indicated that larvae survival rate had significant differences between treatment 2 and other treatments (P<0.05). These indices increase in broodstock weight up to treatment 2 (4518±780g, 79.12±4.36cm) and after that it will be lowered. We conclude that the treatment 2 broodstock are ideal for fingerling survival and enhancement of growth and condition factors

The Effect of Cortex/Medulla Proportions on Molecular Diagnoses in Kidney Transplant Biopsies: Rejection and Injury Can Be Assessed in Medulla

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/137720/1/ajt14233_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/137720/2/ajt14233.pd

Evidence for Gross Domestic Product growth time delay dependence over Foreign Direct Investment. A time-lag dependent correlation study

This paper considers an often forgotten relationship, the time delay between a cause and its effect in economies and finance. We treat the case of Foreign Direct Investment (FDI) and economic growth, - measured through a country Gross Domestic Product (GDP). The pertinent data refers to 43 countries, over 1970-2015, - for a total of 4278 observations. When countries are grouped according to the Inequality-Adjusted Human Development Index (IHDI), it is found that a time lag dependence effect exists in FDI-GDP correlations. This is established through a time-dependent Pearson ’s product-moment correlation coefficient matrix. Moreover, such a Pearson correlation coefficient is observed to evolve 1 from positive to negative values depending on the IHDI, from low to high. It is "politically and policy "relevant" that the correlation is statistically significant providing the time lag is less than 3 years. A "rank-size" law is demonstrated. It is recommended to reconsider such a time lag effect when discussing previous analyses whence conclusions on international business, and thereafter on forecastin

Contribution of non-HLA incompatibility between donor and recipient to kidney allograft survival: genome-wide analysis in a prospective cohort

Background The introduction of HLA matching of donors and recipients was a breakthrough in kidney transplantation. However, half of all transplanted kidneys still fail within 15 years after transplantation. Epidemiological data suggest a fundamental role of non-HLA alloimmunity.Methods We genotyped 477 pairs of deceased donors and first kidney transplant recipients with stable graft function at three months that were transplanted between Dec 1, 2005, and April 30, 2015. Genome-wide genetic mismatches in non-synonymous single nucleotide polymorphisms (nsSNPs) were calculated to identify incompatibilities in transmembrane and secreted proteins. We estimated the association between nsSNP mismatch and graft loss in a Cox proportional hazard model, adjusting for HLA mismatch and clinical covariates. Customised peptide arrays were generated to screen for antibodies against genotype-derived mismatched epitopes in 25 patients with biopsy-confirmed chronic antibody-mediated rejection.Findings 59 268 nsSNPs affecting a transmembrane or secreted protein were analysed. The median number of nsSNP mismatches in immune-accessible transmembrane and secreted proteins between donors and recipients was 1892 (IQR 1850-1936). The degree of nsSNP mismatch was independently associated with graft loss in a multivariable model adjusted for HLA eplet mismatch (HLA-A, HLA-B, HLA-C, HLA-DP, HLA-DQ, and HLA-DR). Each increase by a unit of one IQR had an HR of 1.68 (95% CI 1.17-2.41, p=0.005). 5-year death censored graft survival was 98% in the quartile with the lowest mismatch, 91% in the second quartile, 89% in the third quartile, and 82% in the highest quartile (p=0.003, log-rank test). Customised peptide arrays verified a donor-specific alloimmune response to genetically predicted mismatched epitopes.Interpretation Genetic mismatch of non-HLA haplotypes coding for transmembrane or secreted proteins is associated with an increased risk of functional graft loss independently of HLA incompatibility. As in HLA alloimmunity, donor-specific alloantibodies can be identified against genotype derived non-HLA epitopes.Funding Austrian Science Fund, WWTF (Vienna Science and Technology Fund), and Ministry of Health of the Czech Republic. Copyright (c) 2019 Elsevier Ltd. All rights reserved.Transplantation and autoimmunit