Growing Teratoma Syndrome and Peritoneal Gliomatosis

The growing teratoma syndrome (GTS) is defined as a detection of an enlarged mass during or after chemotherapy treatment for germ cell tumor. We report a case of an 18-year-old girl treated for growing teratoma syndrome after chemotherapy for malignant germ cell tumor of the ovary associated with peritoneal gliomatosis. Chemotherapy induced normalisation of alpha-fetoprotein rate whereas there was an enlargement of the mass. Subsequent complete resection was performed, and the patient remained in good control for 60 months. This clinical picture suggested the diagnosis of “GTS”. This syndrome can lead to confusion with progression or relapse of a germ cell tumour because of increase in tumour volume during chemotherapy, so it is important to recognize it

Léiomyosarcome pleural primitif: à propos d’un cas

Nous rapportons le cas d'un léiomyosarcome pleural primitif, localement avancé, chez un homme de 64 ans, traité par chimiothérapie. La circonstance de découverte est une masse intra-thoracique, augmentant progressivement de volume, dans un contexte de fièvre et d'altération de l'état général. La tomodensitométrie abdominale a objectivé la tumeur. L'exploration chirurgicale a révélé une tumeur pleurale, très localement avancée, envahissant le médiastin. Une simple biopsie a été réalisée. L'examen anatomopathologique avec complément immunohistochimique était en faveur d'un léiomyosarcome de haut grade. Notre patient a reçu une chimiothérapie à base de Doxorubicine à la dose de 60 mg / m², administrée tous les 21 jours. L'évaluation après 6 cycles de chimiothérapie a retrouvé un bénéfice clinique et une réponse partielle radiologique estimée à 30%. Actuellement, il est en bon contrôle.Key words: Léiomyosarcome, plèvre, chimiothérapi

Spécificité de la transformation sarcomateuse de la maladie de Recklinghaussen : a propos de deux cas et revue de la littérature

5 à 10% des patients atteints de neurofibromatose de type 1 (NF1) développent des tumeurs malignes des gaines des nerfs périphériques  (Malignant peripheral nerve sheath tumor: MPNST) contre 0.001% dans la population générale. A travers deux observations et une revue de la littérature nous discuterons la spécificité de la transformation sarcomateuse au cours de la neurofibromatose de type 1.Key words: Maladie de Recklinghausen, transformation sarcomateuse, neurofibromatose de type

Primary non-Hodgkin’s lymphoma of the bladder: case report and literature review

Primary non-Hodgkin's lymphoma (NHL) of the bladder is a very rare entity. The clinical, radiological and endoscopic signs are not specifics. The diagnosis is exclusively histological. Chemotherapy, radiotherapy and surgery are the different therapeutic options used either alone or in combination. We report a 57 years old patient treated with chemotherapy (6 cycles of R-CHOP) for primary NHL of the bladder with a complete response while discussing the different specificities of this disease.Key words: Primary lymphoma, Non-Hodgkin’s lymphoma, Bladder, Chemotherap

Renal oncocytoma: experience of Clinical Urology A, Urology Department, CHU Ibn Sina, Rabat, Morocco and literature review

Renal oncocytoma is a rare and benign renal tumor. Only few cases have been reported in Moroccan populations. In the present study, we reportour experiences in the diagnosis, management and follow-up of this disease. We report on six cases of renal oncocytoma indentified between 1990 and 2008 in the urology department of “CHU Ibn Sina” in Rabat. These six cases are listed among 130 kidney tumors reported during the study period. We assess the clinical, radiological and therapeutic features of the patients and we review literature. Six cases of renal oncocytoma,representing 4.6% of all primitive kidney tumors treated in our institution during the study period. The mean age was 53 ±9.7 years (range 34 to61 years). One patient was asymptomatic at presentation, five patients (83%) had flank pain and two (33%) had macroscopic hematuria. Thetumor was right sided in 4 cases (66%) and left sided in 2 cases (33%). All patients underwent CT scan which showed, in three cases, a centrallylocated stellate area of low attenuation. The clinical suspicion of  oncocytoma was made preoperatively in only 3 patients by imaging studies, but the suspicion of renal cell carcinoma persist and all patients were treated with radical nephrectomy. Definitive diagnosis was made in all cases postoperatively. All the tumors were well circumscribed but unencapsulated. The mean tumor size was 8,75±2,04 cm. Four patients were classified at stage pT2 and two at stage p T1. Most of the pathological features in our patients were typical of this entity.  Predominant cell type was a typical oncocytoma with general low mitotic activity. No extension to peri-nephric fat tissue or lymphovascular invasion was observed. After a mean follow-up of 36 months (range 26-62 months), there was neither recurrence nor death from oncocytoma. Accordingly, the disease-specific survival was 100%. Renal oncocytoma has a benign clinical course with excellent long-term outcomes. In our series, it happened mostly in females and is more frequently symptomatic. Although radical nephrectomy is the usual treatment, a conservative approach should be considered whenever there are signs of clinical and radiological presumptions.Key words: Renal oncocytoma, tumor, diagnosis, treatmen

Séminome Spermatocytaire: à Propos d’un Cas et Revue de La Littérature Spermatocytic Seminoma

Le séminome spermatocytaire est une tumeur rare, représentant moins de 2% des cancers du testicule, survenant essentiellement chez le sujet âgé. Nous rapportons une nouvelle observation d’un patient âgé de 48 ans. La tumeur se présentait comme une prolifération de cellules en nappescompactes, avec 3 types cellulaires, des cellules de petite taille, des cellules intermédiaires et des grandes cellules. Il n’a été retrouvé ni contingent sarcomateux, ni séminome classique. L’analyse en immun histochimie n’a retrouvé aucune expression des cellules tumorales pour les anticorpsclassiques testés, notamment l’Ac anti PLAP et les marqueurs lymphoïdes. Le séminome spermatocytaire doit être reconnu, car son évolution est très favorable et ne nécessite qu’une simple orchidectomie, en l’absence d’un exceptionnel contingent sarcomateux ou de métastase où une chimiothérapie s’impose

Primary osteosarcoma of the breast: case report

Mammary sarcomas are very uncommon and make up less than 1% of all primary breast malignancies

Transitional cell carcinoma of the ovary: A rare case and review of literature

<p>Abstract</p> <p>Introduction</p> <p>Transitional cell carcinoma (TCC) of the ovary is a rare, recently recognized, subtype of ovarian surface epithelial cancer.</p> <p>Case presentation</p> <p>A 69-year-old postmenopausal woman presented with a 2-year history of progressive enlargement of an abdominal mass. Abdominal computed tomography showed a pelvic mass. CA-125 was normal. A staging operation with total abdominal hysterectomy, bilateral salpingo-oophorectomy, infracolic omentectomy and pelvic lymph node dissection was performed. After surgery, the pathologic report of the right ovarian tumour was TCC, grade 3, stage IC. The patient underwent 3 cycles of chemotherapy: carboplatin and paclitaxel. She is regularly followed up and has been disease free for 10 months</p> <p>Conclusion</p> <p>Transitional cell carcinoma (TCC) of the ovary is a rare subtype of epithelial ovarian cancer. Surgical resection is the primary therapeutic approach, and patient outcomes after chemotherapy are better than for other types of ovarian cancers.</p

Case Report Bilateral Ewing Sarcoma/Primitive Neuroectodermal Tumor of the Breast: A Very Rare Entity and Review of the Literature

Peripheral primitive neuroectodermal tumors (PNET) are rare malignant tumors, affecting mostly children and adolescents and have been described in breast in eight case reports only. In this paper, we present a case of bilateral mammary ES/PNET where distinction between primary and metastatic diseases was discussed through a literature review. The aim of this work is to demonstrate that although rare, the possibility of PNET should be kept in mind while evaluating a palpable breast abnormality in a young female

Triple malignancy in a single patient including a cervical carcinoma, a basal cell carcinoma of the skin and a neuroendocrine carcinoma from an unknown primary site: A case report and review of the literature

<p>Abstract</p> <p>Introduction</p> <p>The occurrence of multiple primary cancers is rare. Only a few cases and patient reviews of an association of triple malignancy have been reported.</p> <p>Case presentation</p> <p>We report here a case of a 78-year-old Moroccan woman presenting initially with a synchronous double malignancy, the first in her cervix and the second in her skin. Our patient was treated with radiation therapy for both tumors and remained in good control for 17 years, when she developed a metastatic disease from a neuroendocrine carcinoma of an unknown primary site.</p> <p>Conclusions</p> <p>Although the association of multiple primary cancers can be considered a rare occurrence, improving survival in cancer patients has made this situation more frequent.</p