Mapping dynamic interactions among cognitive biases in depression

Depression is theorized to be caused in part by biased cognitive processing of emotional information. Yet, prior research has adopted a reductionist approach that does not characterize how biases in cognitive processes such as attention and memory work together to confer risk for this complex multifactorial disorder. Grounded in affective and cognitive science, we highlight four mechanisms to understand how attention biases, working memory difficulties, and long-term memory biases interact and contribute to depression. We review evidence for each mechanism and highlight time- and context-dependent dynamics. We outline methodological considerations and recommendations for research in this area. We conclude with directions to advance the understanding of depression risk, cognitive training interventions, and transdiagnostic properties of cognitive biases and their interactions

Attentional control in depression: a translational affective neuroscience approach

Translational research refers to the application of basic science to address clinical problems and acquire knowledge that can be used to guide and refine clinical practice. This special issue of Cognitive, Affective, & Behavioral Neuroscience seeks to explore and integrate some of the most promising findings offered by recent cognitive and affective neuroscience studies in hopes of filling the gap between basic and applied research, thereby heightening our understanding of vulnerability for depression. The studies presented in this special issue focus specifically on attentional processes. We solicited contributions from leading researchers involved in basic cognitive and neuroscience research investigating processes underlying depression-related disturbances in emotion processing. In this introductory article, we present an integrative overview to demonstrate how these specific contributions might be valuable for translational research

Genotoxicity of nitroso compounds and sodium dichromate in a model combining organ cultures of human nasal epithelia and the comet assay

Genotoxic effects of xenobiotics are a possible step in tumor initiation in the mucosa of the upper aerodigestive tract. Using the comet assay, detecting genotoxicity in human tissue has been restricted to single incubations in vitro, but in vivo most xenobiotics harm their target in a repetitive or chronic manner. Therefore, we propose a model, which provides repetitive incubations in human upper aerodigestive tract mucosa cultures. Samples of human inferior nasal turbinate mucosa (n = 25) were cultured according to a modified version of a technique originally described by Steinsvag. On day 1 fresh samples and on days 7, 9 and 11 organ cultures were incubated with N-nitrosodiethylamine (NDEA), sodium dichromate (Na2Cr2O7) and N'-methyl-N-nitro-N-nitrosoguanidine(MNNG). Mucosa samples and organ cultures, respectively, underwent a modified comet assay on days 1, 7 and 11. Genotoxicity could be shown for NDEA, Na2Cr2O7 and MNNG on days 1, 7 and 11. Duration of tissue culture and repetitive incubations did not significantly influence the results for NDEA. Nevertheless, Na2Cr2O7 and MNNG caused higher genotoxic effects on cultures subjected to the comet assay on day 11. This model may help to assess genotoxic hazards posed by environ mental pollutants that have a cumulative character in repetitive or chronic exposure in vivo. Copyright (C) 2001 S. Karger AG, Basel

Analyzing the Psychological and Social Contents of Evidence—Experimental Comparison between Guessing, Naturalistic Observation, and Systematic Analysis

To improve inferences about psychological and social evidence contained in pictures and texts, a five-step algorithm—Systematic Analysis (SA)—was devised. It combines basic principles of interpretation in forensic science, providing a comprehensive record of signs of evidence. Criminal justice professionals evaluated the usefulness of SA. Effects of applying SA were tested experimentally with 41 subjects, compared to 39 subjects observing naturally (naturalistic observation) and 47 subjects guessing intuitively intuitive guessing group. After being trained in SA, prosecutors and police detectives (N = 217) attributed it a good usefulness for criminal investigation. Subjects (graduate students) using SA found significantly more details about four test cases than those observing naturally (Cohen’s d = 0.58). Subjects who learned SA well abducted significantly better hypotheses than those who observed naturally or who guessed intuitively. Internal validity of SA was a = 0.74. Applying SA improved observation significantly and reduced confirmation bias

The awareness of the scared - context dependent influence of oxytocin on brain function

Oxytocin is both a hormone and a neurotransmitter and has been originally recognized for its role in childbirth and lactation. Later, it became widely known as a "cuddle hormone" that induces trusting behavior towards strangers and reduces social stress and anxiety. Several studies showed that oxytocin influences empathic behavior and has prosocial effects. The anterior cingulate cortex and the anterior insula are brain regions that are active when humans observe fear in others. Therefore, the aim of this study was to investigate whether oxytocin administration affects activity in these regions depending on whether a threat is directed at another person (empathy) compared to when the threat is directed at the subject itself (fear). Our findings demonstrate increased anterior cingulate cortex activation after oxytocin administration in the fear, but not in the empathy condition. Furthermore, oxytocin administration was associated with deceased anterior insula activity in the empathy condition. However, our findings do not support the idea that oxytocin generally augments activity in brain regions associated with empathy. Thereby this study supports current research questioning that oxytocin has exclusively prosocial effects on human behavior. Rather, the effect of oxytocin depends on various contextual (e.g. presence of a familiar person) and interindividual (e.g. sex, mental disorder) factors. Therefore, to consider oxytocin an empathy inducing hormone is an oversimplification and future research should focus on factors moderating oxytocin effects

Outside the Mainstream Press: Language, Materiality, and Temporality in Microzines

This article examines aesthetic strategies employed in the modernist little magazine and contemporary independent magazines. Language, materiality, and temporality are found to be key elements for experimental multimodal expressions challenging mainstream periodical cultures. In order to emphasize parallels between precarious, noncommercial, and innovative micro-publishing practices of the twentieth and twenty-first centuries, we propose to use the term ‘microzine’. In three case studies, we offer analyses of linguistic defamiliarization, typography and design, and the representation of temporal experiences of migrancy to highlight the entanglement of aesthetic strategies as well as their persistence over time. This comparison of the Little Review (1914–29), NXS (2017–2022), and Burnt Roti (2016–) opens up possibilities to view disparate non-mainstream magazine projects as potent incubatory spaces for new magazinal assemblages

Im Spannungsfeld zwischen «safety first» und «patient first»: Freiheitseinschränkende Massnahmen im Akutspital

Bei selbst- oder fremdgefährdendem Verhalten können im Akutspital freiheitseinschränkende Massnahmen (FEM) unvermeidlich sein, um das Wohl und die Interessen betroffener und beteiligter Personen zu schützen. Handlungsleitende Vorgaben aus dem ethischen und rechtlichen Bereich sehen primär personenbezogene Gründe vor, die eine Einschränkung der Freiheit rechtfertigen. In der Praxis spielen jedoch auch kontextbezogene Gründe eine Rolle. Vor diesem Hintergrund zeigt unser Beitrag das Spannungsfeld zwischen rechtlichen Vorgaben, ethischen Orientierungen und klinischer Praxis im Kontext eines Schweizer Universitätsspitals auf. Wir beschreiben Strategien für den Umgang mit diesem Spannungsfeld. Zentral ist die Sensibilisierung der Fachpersonen für den Ausnahmecharakter der FEM. Ebenso erweisen sich die Transparenz des Entscheidungsprozesses und die Nachvollziehbarkeit der Dokumentation bzw. Evaluation als wichtig

Effects of Psychotherapy on Glutamatergic Neurotransmission

Introduction: Psychodynamic psychotherapy is an effective and widely used treatment for major depressive disorder (MDD); however, little is known about neurobiological changes associated with induced symptom improvement. Methods: Proton magnetic resonance spectroscopy with a two-dimensional J-resolved sequence served to test the relationship between glutamate (Glu) and glutamine (Gln) levels, measured separately in pregenual anterior cingulate cortex (pgACC) and the anterior midcingulate cortex (aMCC) as a control region, with change in depression symptoms after 6 months of weekly psychodynamic psychotherapy sessions in MDD patients. Depressed (N = 45) and healthy (N = 30) subjects participated in a baseline proton magnetic resonance spectroscopy measurement and a subgroup of MDD subjects (N = 21) then received once-a-week psychodynamic psychotherapy and participated in a second proton magnetic resonance spectroscopy measurement after 6 months. Change in depression symptoms was assessed using the Hamilton Depression Rating Scale (HAMD). Results: Higher pretreatment pgACC Gln concentrations in MDD patients compared to healthy controls were associated with symptom severity. Patients and controls did not differ regarding Gln levels in aMCC nor regarding Glu levels in both regions. The association of pgACC Gln concentration and severity of depressive symptoms was reversed after 6 months of psychotherapy in MDD subjects. Regarding Gln in aMCC as well as Glu in both regions, there were no significant associations with improvement of depressive symptoms in the course of psychotherapy. Discussion: Findings indicate specific regional effects of psychodynamic psychotherapy on glutamatergic neurotransmission and thereby highlight the key role of the pgACC in both depression pathophysiology and recovery