Synthesis of β‑<i>C</i>‑GlcNAc Ser from β‑<i>C</i>‑Glc Ser

The glycosylation of proteins, specifically installation of <i>O</i>-GlcNAc on Ser/Thr residues, is a dynamic control element for transcription repression, protein degradation, and nutrient sensing. To provide homogeneous and stable structures with this motif, the synthesis of a C-linked mimic, <i>C</i>-GlcNAc Ser, has been prepared from the <i>C</i>-Glc Ser by a double inversion strategy using azide to insert the C-2 nitrogen functionality. The <i>C</i>-Glc Ser was available by a ring-closing metathesis and hydroalkoxylation route

1_Diaminopyridoisoquinolinedione lyotropic liquid crystalline texture #1 LCTextures_19 copy.tif

<p>Diaminopyridoisoquinolinedione, compound <b>3</b> published in:</p>"<i>Janus</i> molecules: Synthesis of double-headed heterocycles containing two identical hydrogen bonding arrays" Andrew Marsh, Ernest G. Nolen, Kevin M. Gardinier, Jean-Marie Lehn <i>Tetrahedron Letters</i> <b>1994</b>, <i>35</i>, 397-400.<div><br></div><div><p>3,7-bis((4-dodecylphenyl)amino)pyrido[4,3-<i>g</i>]isoquinoline-1,9(2<i>H</i>,8<i>H</i>)-dione</p></div><div><br><div><br></div><div>SMILES</div></div><p>O=C1N([H])C(N(C2=CC=C(CCCCCCCCCCCC)C=C2)[H])=CC3=C1C=C(C(N([H])C(N([H])C4=CC=C(CCCCCCCCCCCC)C=C4)=C5)=O)C5=C3</p><p><br></p

Lindera membranacea Maxim.

原著和名: オホバクロモジ科名: クスノキ科 = Lauraceae採集地: 青森県 下北郡 宇曽利山 (陸奥 下北郡 宇曽利山)採集日: 1962/6/16採集者: 萩庭丈壽整理番号: JH043009国立科学博物館整理番号: TNS-VS-99300

7_Diaminopyridoisoquinolinedione lyotropic liquid crystal texture #7 LCTextures_12.tif

<p>Diaminopyridoisoquinolinedione, compound <b>3</b> published in:</p>"<i>Janus</i> molecules: Synthesis of double-headed heterocycles containing two identical hydrogen bonding arrays" Andrew Marsh, Ernest G. Nolen, Kevin M. Gardinier, Jean-Marie Lehn <i>Tetrahedron Letters</i> <b>1994</b>, <i>35</i>, 397-400.<div><br></div><div><p>3,7-bis((4-dodecylphenyl)amino)pyrido[4,3-<i>g</i>]isoquinoline-1,9(2<i>H</i>,8<i>H</i>)-dione</p></div><div><br><div><br></div><div>SMILES</div><div>O=C1N([H])C(N(C2=CC=C(CCCCCCCCCCCC)C=C2)[H])=CC3=C1C=C(C(N([H])C(N([H])C4=CC=C(CCCCCCCCCCCC)C=C4)=C5)=O)C5=C3</div></div

13_Diaminopyridoisoquinolinedione lyotropic liquid crystal texture #13 LCTextures_7.tif

<p>Diaminopyridoisoquinolinedione, compound <b>3</b> published in:</p><p>"<i>Janus</i> molecules: Synthesis of double-headed heterocycles containing two identical hydrogen bonding arrays" Andrew Marsh, Ernest G. Nolen, Kevin M. Gardinier, Jean-Marie Lehn <i>Tetrahedron Letters</i> <b>1994</b>, <i>35</i>, 397-400.</p><div><br></div><div><p>3,7-bis((4-dodecylphenyl)amino)pyrido[4,3-<i>g</i>]isoquinoline-1,9(2<i>H</i>,8<i>H</i>)-dione</p></div><div><br><div><br></div><div>SMILES</div><div>O=C1N([H])C(N(C2=CC=C(CCCCCCCCCCCC)C=C2)[H])=CC3=C1C=C(C(N([H])C(N([H])C4=CC=C(CCCCCCCCCCCC)C=C4)=C5)=O)C5=C3</div></div

9_Diaminopyridoisoquinolinedione lyotropic liquid crystal texture #9 LCTextures_3 copy.tif

<p>Diaminopyridoisoquinolinedione, compound <b>3</b> published in:</p>"<i>Janus</i> molecules: Synthesis of double-headed heterocycles containing two identical hydrogen bonding arrays" Andrew Marsh, Ernest G. Nolen, Kevin M. Gardiner, Jean-Marie Lehn <i>Tetrahedron Letters</i> <b>1994</b>, <i>35</i>, 397-400.<div><br></div><div><p>3,7-bis((4-dodecylphenyl)amino)pyrido[4,3-<i>g</i>]isoquinoline-1,9(2<i>H</i>,8<i>H</i>)-dione</p></div><div><br><div><br></div><div>SMILES</div><div>O=C1N([H])C(N(C2=CC=C(CCCCCCCCCCCC)C=C2)[H])=CC3=C1C=C(C(N([H])C(N([H])C4=CC=C(CCCCCCCCCCCC)C=C4)=C5)=O)C5=C3</div></div