"Singing brings joy to the distressed": the social history of Zulu migrant workers' choral competitions

Paper presented at the Wits History Workshop: The Making of Class, 9-14 February, 198

Nuclear-Targeted Deleted in Liver Cancer 1 (DLC1) Is Less Efficient in Exerting Its Tumor Suppressive Activity Both In Vitro and In Vivo

BACKGROUND: Deleted in liver cancer 1 (DLC1) serves as an important RhoGTPase activating protein (RhoGAP) protein that terminates active RhoA signaling in human cancers. Increasing evidence has demonstrated that the tumor suppressive activity of DLC1 depends not only on RhoGAP activity, but also relies on proper focal adhesion localization through its interaction with tensin family proteins. Recently, there are reports showing that DLC1 can also be found in the nucleus; however, the existence and the relative tumor suppressive activity of nuclear DLC1 have never been clearly addressed. METHODOLOGY AND PRINCIPAL FINDINGS: We herein provide new evidence that DLC1 protein, which predominantly associated with focal adhesions and localized in cytosol, dynamically shuttled between cytoplasm and nucleus. Treatment of cells with nuclear export blocker, Leptomycin B (LMB), retained DLC1 in the nucleus. To understand the nuclear entry of DLC1, we identified amino acids 600-700 of DLC1 as a novel region that is important for its nuclear localization. The tumor suppressive activity of nuclear DLC1 was directly assessed by employing a nuclear localization signal (NLS) fusion variant of DLC1 (NLS-DLC1) with preferential nuclear localization. In SMMC-7721 HCC cells, expression of NLS-DLC1 failed to suppress colony formation and actin stress fiber formation in vitro. The abrogated tumor suppressive activity of nuclear DLC1 was demonstrated for the first time in vivo by subcutaneously injecting p53(-/-) RasV12 hepatoblasts with stable NLS-DLC1 expression in nude mice. The injected hepatoblasts with NLS-DLC1 expression effectively formed tumors when compared with the non-nuclear targeted DLC1. CONCLUSIONS/SIGNIFICANCE: Our study identified a novel region responsible for the nuclear entry of DLC1 and demonstrated the functional difference of DLC1 in different cellular compartments both in vitro and in vivo

Aficionados, academics, and Danzón expertise: exploring hierarchies in popular music knowledge production

Amateur scholars, such as aficionados, fans, intellectuals, are rarely valued in the twenty-first-century academy, despite their often-encyclopedic knowledge. In this paper, I focus on Mexican aficionados of the popular Cuban music danzón to explore how these mostly older men manage social contexts where they are often marginalized. Drawing on Bourdieu, I examine how danzón aficionados negotiate their field of expertise by employing overlapping strategies: accumulating myriad "facts" and "truths", creating the possibility of ignorance in others, and competing for hegemonic masculine capital. I analyze danzón aficionados' relationships with musicians and dancers, consider power dynamics between these aficionados and academics, and draw on Léon and Romero to discuss relationships between regional and hegemonic scholarship more broadly. I argue that beyond reflexivity and criticism, collective activism is required to reconfigure value systems and symbolic economies, and to fight institutional pressures to reproduce existing power structure

Nightsong : performance, power, and practice in South Africa

Joh: Martin Veith pinxit ; Joseph Clausner Sculp:Unten Mitte bezeichnet "Ex Collectione Joh. Casparri Otti"Unten links auf Unterlage mit Feder in Braun vermutlich von Hans Caspar Ott bezeichnet "2ter Probedruck von Zug, 31te Julij 87"Vgl. Icones Ottiorum, hrsg. von Hans Kaspar Ott, ca. 1790, Abb. 15 (Ex. mit 55 Druckgrafiken unter Sign. KK 592)Aus der Sammlung Hans Kaspar Ott-Escher in der Engelburg (1740–1799) Exemplar der Zentralbibliothek Zürich, Graphische Sammlung und FotoarchivAus der Sammlung Leonhard Ziegler zum Egli (1782-1854) Exemplar der Zentralbibliothek Zürich, Graphische Sammlung und Fotoarchiv2. Probedruck mit Text Exemplar der Zentralbibliothek Zürich, Graphische Sammlung und Fotoarchi