Neural Responses to Feedback Regarding Betrayal and Cooperation in Adolescents with Anxiety and Mood Disorders

This study examined patterns of neural response to feedback regarding betrayal and cooperation in adolescents with anxiety/mood disorders and healthy peers. We compared performance on and neural activation patterns during the Prisoner’s Dilemma (PD) game, an economic exchange task involving betrayal and cooperation, between age- and IQ-matched groups of adolescents with anxiety/depressive disorders (A/D) (N=13) and healthy controls (n=17). Participants were deceived to believe that their co-player (a pre-programmed computer algorithm) was another study participant. Although participants responded similarly following feedback that the co-player had cooperated with them on preceding trials, A/D adolescents were more likely than controls to cooperate following trials when the other player betrayed them. Further, A/D participants differed significantly from controls in patterns of neural activation in response to feedback that they had been betrayed. In particular, A/D participants showed more activation relative to baseline in the precuneus, cerebellum, and supramarginal gyrus than did controls. Groups did not, in contrast, differ significantly in patterns of activation in response to feedback that their co-player had cooperated with them. Our findings provide preliminary evidence that A/D adolescents may not only behave differently than do healthy peers when they encounter potential social obstacles, but that they may also engage a different set of neural resources. These findings offer a first step toward elucidating the mechanisms underlying social impairment in youth with internalizing disorders

Associations among perceptual anomalies, social anxiety, and paranoia in a college student sample

Recent evidence suggests that normal-range paranoid ideation may be particularly likely to arise in individuals disposed to both social anxiety and perceptual anomalies. This study was designed to test the hypothesis that among college students in an unselected sample, social anxiety and experience of perceptual anomalies would not only each independently predict the experience of self-reported paranoid ideation, but would also interact to predict paranoid patterns of thought. A diverse sample of 644 students completed a large battery of self-report measures, as well as the five-factor Paranoia/Suspiciousness Questionnaire (PSQ). We conducted hierarchical multiple regression analyses predicting scores on each PSQ factor from responses on measures of social anxiety, perceptual aberration, and the interaction between the two constructs. Current general negative affect was covaried in all analyses. We found that both social anxiety and perceptual aberrations, along with negative affect, predicted multiple dimensions of paranoia as measured by the PSQ; the two constructs did not, however, interact significantly to predict any dimensions. Our findings suggest that perceptual aberration and anxiety may contribute to normal-range paranoid ideation in an additive rather than an interactive manner

Socio-emotional Functioning in Bipolar Disorder Versus Typical Development: Behavioral and Neural Differences

Socio-emotional dysfunction is a core feature of bipolar disorder (BD) across the lifespan. Recent evidence indicates associations between this atypical functioning and the presence of neurally-based anomalies. This article critically reviews the literature on two types of core socioemotional skills that may represent endophenotypes for BD, with a focus on differences between individuals with BD, both youth and adults, and their typically developing peers. First, it examines studies of social cue perception and interpretation, with an emphasis on behavioral and neural studies of facial expression processing. Second, it shifts to examine behavioral and neural differences in cognitive and behavioral flexibility. Finally, the article summarizes potential future directions for research in this area

Paranoid Thinking, Suspicion, and Risk for Aggression: A Neurodevelopmental Perspective

This article represents an effort to extend our understanding of paranoia or suspicion and its development by integrating findings across clinical, developmental, and neuroscience literatures. We first define “paranoia” or paranoid thought and examine its prevalence across typically and atypically developing individuals and theoretical perspectives regarding its development and maintenance.We then briefly summarize current ideas regarding the neural correlates of adaptive, appropriately trusting interpersonal perception, social cognition, and behavior across development. Our focus shifts subsequently to examining in normative and atypical developmental contexts the neural correlates of several component cognitive processes thought to contribute to paranoid thinking: (a) attention bias for threat, (b) jumping to conclusions biases, and (c) hostile intent attribution biases. Where possible, we also present data regarding independent links between these cognitive processes and aggressive behavior. By examining data regarding the behavioral and neural correlates of varied cognitive processes that are likely components of a paranoid thinking style, we hope to advance both theoretical and empirical research in this domain

An examination of the factorial structure of the Schizotypal Personality Questionnaire–Brief (SPQ-B) among undergraduate students

Cognitive-perceptual, interpersonal, and disorganized subscales of the Schizotypal Personality Questionnaire–Brief (SPQ-B), reflecting the three commonly used subscales of the full-version SPQ, have been used in a number of studies. However, the factorial validity of SPQB subscales remains to be clarified. Utilizing data from 825 undergraduate students, confirmatory factor analyses involving the 22 items of the SPQ-B were conducted. A significant χ2 difference test favored the 3-factor over the 1-factor model and fit indices for the 3-factor model were generally satisfactory. However, several of the items may index more than one of the hypothesized factors, so the item-factor separation is not sharp. Thus, more research is needed on the factorial validity of the increasingly used SPQ-B subscales

Confirmation of a Four-Factor Structure of the Schizotypal Personality Questionnaire among Undergraduate Students

Objective Although several exploratory and confirmatory factor analyses have supported the initially proposed factor structure of the Schizotypal Personality Questionnaire (SPQ) in which its nine subscales are grouped into cognitive-perceptual, interpersonal, and disorganized domains, others have revealed different latent structures. This study determined the best-fitting factor structure from among five models that have been proposed in the literature, as well as five additional hierarchically related models. Method Undergraduate college students (n=825) completed the SPQ as well as the Perceptual Aberration Scale (PAS) and the Revised Social Anhedonia Scale (SAS). Confirmatory factor analyses involving the nine SPQ subscales were conducted using the Linear Structural Relations Program (LISREL 8.72). Results The best fitting model was a previously described 4-factor model including cognitiveperceptual, paranoid, negative, and disorganized domains. Correlations between the derived SPQ domains and the PAS score ranged r=.26–.39, and correlations between the SPQ domains and the SAS ranged r=.07–.41. Conclusions The present findings support a 4-factor model over the standard 3-factor model that is typically used to derive SPQ subscale scores. The four derived domains are minimally to moderately correlated with other measures of psychosis-proneness

Schizotypy and Nicotine, Alcohol, and Cannabis Use in a Non-Psychiatric Sample

Schizotypy is a multidimensional personality construct that is characterized by perceptual abnormalities, social withdrawal, mild suspiciousness, and odd thinking patterns. This study examined the relationship between four dimensions of self-reported schizotypy and substance use involving nicotine, alcohol, and cannabis, in undergraduate students. Results showed that higher levels of disorganized schizotypy, or odd thinking and behavior, were associated with greater indices of use of all three substances. Furthermore, higher cognitive-perceptual schizotypy was selectively associated with cannabis use. Results confirm findings of recent research that has discovered associations among schizotypy and substance use, highlighting links between behavioral traits and use of nicotine, alcohol, and cannabis. This study is one of the first to examine a wide range of schizotypy domains, and to show selective effects of the disorganized domain of schizotypy

Latent Factor Modeling of Four Schizotypy Dimensions with Theory of Mind and Empathy

Preliminary evidence suggests that theory of mind and empathy relate differentially to factors of schizotypy. The current study assessed 686 undergraduate students and used structural equation modeling to examine links between a four-factor model of schizotypy with performance on measures of theory of mind (Reading the Mind in the Eyes Test [MIE]) and empathy (Interpersonal Reactivity Index [IRI]). Schizotypy was assessed using three self-report measures which were simultaneously entered into the model. Results revealed that the Negative factor of schizotypy showed a negative relationship with the Empathy factor, which was primarily driven by the Empathic Concern subscale of the IRI and the No Close Friends and Constricted Affect subscales of the Schizotypal Personality Questionnaire. These findings are consistent with a growing body of literature suggesting a relatively specific relationship between negative schizotypy and empathy, and are consistent with several previous studies that found no relationship between MIE performance and schizotypy