Occupational exposition the endocrine interfering and effect on the masculine reproductive system

Made available in DSpace on 2012-09-06T01:12:16Z (GMT). No. of bitstreams: 2 license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) 671.pdf: 214900 bytes, checksum: 9261a44ca6916f6c3d8af13b40cd639a (MD5) Previous issue date: 2005Fundação Oswaldo Cruz. Escola Nacional de Saúde Pública Sergio Arouca. Rio de Janeiro, RJ, Brasil.Foi realizada revisão bibliográfica de literatura especializada sobre as principais causas ocupacionais de infertilidades masculinas, apresentadas sob a forma de artigo. Fez-se descrição sucinta das principais causas gerais da infertilidade masculina, separadas em causas internas ou orgânicas e causas externas, estas subdivididas em causas externas de origem não laboral e origem laboral. Incluem-se no trabalho explanações sobre o aparelho reprodutor masculino e sobre interferentes endócrinos. No artigo são destacados os principais efeitos da exposição ocupacional aos interferentes endócrinos sobre a fertilidade masculina. A exposição ocupacional de trabalhadores a substâncias interferentes do sistema endócrino como os agrotóxicos, metais pesados e resíduos de processos industriais podem causar danos no sistema endócrino e estes podem levar à infertilidade masculina. Um significativo aumento na incidência de infertilidade masculina tem sido descrito na literatura, tornando necessário à realização de mais estudos que possam elucidar e determinar as causas desta questão. Desta forma será possível projetar medidas de proteção dos trabalhadores potencialmente expostos.This paper develops provides an overview of male infertility. There is a brief description of the main causes of male infertility, divided by in internal or organic and external causes (labor and nonlabor origins). In the present paper, explanations about the male reproductive organ and endocrines disruptors are included. The literature review emphasizes the main effects of exposition to endocrines deregulators exposition over male fertility. The occupational exposition of workers to deregulating substances, such as pesticides, heavy metals and residues of industrial processes can cause damages to the endocrine system leading to male infertility. A significant increase in male infertility incidence having been described in the literature, making necessary problem of further studies to clarify and determine the causes of this fact. Thus, it will be possible to establish methods of protection actions for the potentially exposed workers

Occupational exposure and effects on the male reproductive system

A significant increase in the incidence of male infertility has been described in the international literature, raising questions about its causes. Part of this effect may result from synthetic toxic substances acting on the endocrine system (endocrine disruptors), many of which are routinely used in work processes. We provide a critical review of the specialized literature on work-related chemical substances capable of causing male infertility. Pesticides such as DDT, linuron, and others, heavy metals like mercury, lead, cadmium, and copper, and substances from various industrial uses and residues such as dioxins, polychlorinated biphenyls (PCBs), ethylene dibromide (EDB), phthalates, polyvinyl chloride (PVC), and ethanol are among the main endocrine disruptors that can cause male infertility. Based on the literature, gonadal dysfunction and congenital malformation are the main alterations caused by these substances in the male reproductive system. We conclude that despite the relative lack of studies on this issue, the relevance of such risk calls for further studies as well as measures to prevent workers' exposure to the various substances