Physiologic parameters given as mean ± SD.

<p>Physiologic parameters given as mean ± SD.</p

IL-6 in cortex or hippocampus.

<p>IL-6 mRNA in cortex (left) or hippocampus (right). * p < 0.05 vs. Ctr.</p

TNFalpha in cortex or hippocampus.

<p>TNFalpha mRNA in cortex (left) or hippocampus (right). * p < 0.05 vs. native.</p

Wet-to-dry ratio and lung injury score.

<p>Wet-to-dry ratio (left) and histologic assessed lung damage score (right). * p < 0.05 vs. Ctr.</p

IL-1beta in cortex or hippocampus.

<p>IL-1beta mRNA in cortex (left) or hippocampus (right).</p

Histology brain.

<p>Number of HE-stained neurons and Iba-1-stained microglia cells.</p

Example of VRI and EIT side-by-side raw data recordings.

<p>Raw data waveforms of one representative breathing-cycle for each of the different measurement time points (BLH: baseline healthy; ALI-0: impaired lungs (ALI) at zero PEEP; ALI-5: ALI at PEEP 5 mbar; ALI-10: ALI at PEEP 10 mbar; ALI-15: ALI at PEEP 15 mbar). Panel A: Vibration energy (VE) over time by VRI. The parameter vibration energy amplitude (VEA) was assessed at the peak flow rate of the inspiratory phase of the breathing cycle. Panel B: Relative impedance changes (rel.Z) over time by EIT. The amplitudes of rel.Z (rel.ΔZ) were assessed by tidal differences between minimum and maximum rel.Z values.</p

Regional Ventilation Distribution as measured by VRI and EIT.

<p>Regional ventilation distribution as measured by VRI and EIT. Values are given as percentage of ventilation as assessed by EIT and VRI, itemized for the different measurement points and respective PEEP levels (BLH: baseline healthy; ALI-0: impaired lungs (ALI) at zero PEEP; ALI-5: ALI at PEEP 5 mbar; ALI-10: ALI at PEEP 10 mbar; ALI-15: ALI at PEEP 15 mbar). Panel A: within ventral and dorsal lung ROI. Panel B: within level 1 (upper ventral), level 2 (middle), and level 3 (lower dorsal) lung ROI.</p

Agreement between estimated V_T by EIT and VRI for different lung regions: Linear correlation and Bland-Altman analysis.

<p>Agreement between estimated V_T by EIT and VRI for the different lung regions of interest (ROIs): linear correlation equation with the corresponding goodness of fit (left). Bias and 1.96-SD limits of the Bland-Altman analysis (right).</p

Influence of lung injury and PEEP on VRI V_T measurement: ANCOVA.

<p>Slopes and intercepts for the different measurement points (BLH: baseline healthy; ALI-0: impaired lungs (ALI) at zero PEEP; ALI-5: ALI at PEEP 5 mbar; ALI-10: ALI at PEEP 10 mbar; ALI-15: ALI at PEEP 15 mbar) are presented on the left. Descriptive measures of the differences in V_T measured by VRI and EIT, displayed as mean±SD (standard deviation) and range [ml] are presented on the right. To investigate the influence of lung damage and PEEP on EIT and VRI V_T measures, an ANCOVA was used to test the equality of slopes and intercepts (using an F test to compare a global model where slope is shared among the data sets, with a model where each dataset gets its own slope). The first <i>P</i>-value tested the null hypothesis that the slopes are all identical (the lines are parallel). The second <i>P</i>-value represents the results of testing the null hypothesis that the intercepts are identical.</p