The effects of a 12-Month weight loss intervention on cognitive outcomes in adults with overweight and obesity

Obesity is associated with poorer executive functioning and reward sensitivity. Yet, we know very little about whether weight loss through diet and/or increased exercise engagement improves cognitive function. This study evaluated whether weight loss following a dietary and exercise intervention was associated with improved cognitive performance. We enrolled 125 middle-aged adults with overweight and obesity (98 female) into a 12-month behavioral weight loss intervention. Participants were assigned to one of three groups: energy-restricted diet alone, an energy-restricted diet plus 150 min of moderate intensity exercise per week or an energy restricted diet plus 250 min of exercise per week. All participants completed tests measuring executive functioning and/or reward sensitivity, including the Iowa Gambling Task (IGT). Following the intervention, weight significantly decreased in all groups. A MANCOVA controlling for age, sex and race revealed a significant multivariate effect of group on cognitive changes. Post-hoc ANCOVAs revealed a Group x Time interaction only on IGT reward sensitivity, such that the high exercise group improved their performance relative to the other two intervention groups. Post-hoc ANCOVAs also revealed a main effect of Time, independent of intervention group, on IGT net payoff score. Changes in weight were not associated with other changes in cognitive performance. Engaging in a high amount of exercise improved reward sensitivity above and beyond weight loss alone. This suggests that there is additional benefit to adding exercise into behavioral weight loss regimens on executive functioning, even without additional benefit to weight loss

Opportunistic or event-driven maintenance at the Stanford Linear Accelerator Center

The Stanford Linear Accelerator Center (SLAC) uses a maintenance management philosophy that is best described as opportunistic or event-driven. Opportunistic maintenance can be defined as a systematic method of collecting, investigating, pre-planning, and publishing a set of proposed maintenance tasks and acting on them when there is an unscheduled failure or repair ``opportunity``. Opportunistic maintenance can be thought of as a modification of the run-to-fail maintenance management philosophy. This maintenance plan was adopted and developed to improve the overall availability of SLAC`s linear accelerator, beam delivery systems, and associated controls, power systems, and utilities. In the late 1980`s, as the technical complexity of the accelerator facility increased, variations on a conventional maintenance plan were used with mixed results. These variations typically included some type of regular periodic interruption to operations. The periodic shutdowns and unscheduled failures were additive and resulted in unsatisfactory availability. Maintenance issues are evaluated in a daily meeting that includes the accelerator managers, maintenance supervisors and managers, safety office personnel, program managers, and accelerator operators. Lists of pending maintenance tasks are made available to the general SLAC population by a World Wide Web site on a local internet. A conventional information system which pre-dates the WWW site is still being used to provide paper copies to groups that are not yet integrated into the WWW system. The local internet provides real time maintenance information, allowing people throughout the facility to track progress on tasks with essentially real-time status updates. With the introduction of opportunistic maintenance, the accelerator`s availability has been measurably better. This paper will discuss processes, rolls and responsibilities of key maintenance groups, and management tools developed to support opportunistic maintenance

A New Upper Limit for the Tau-Neutrino Magnetic Moment

Using a prompt neutrino beam in which a nu_tau component was identified for the first time, the nu_tau magnetic moment was measured based on a search for an anomalous increase in the number of neutrino-electron interactions. One such event was observed when 2.3 were expected from background processes, giving an upper 90% confidence limit of 3.9x10^-7 Bohr magnetons.Comment: 9 pages; 1 figur

Unconventional Cosmology

I review two cosmological paradigms which are alternative to the current inflationary scenario. The first alternative is the "matter bounce", a non-singular bouncing cosmology with a matter-dominated phase of contraction. The second is an "emergent" scenario, which can be implemented in the context of "string gas cosmology". I will compare these scenarios with the inflationary one and demonstrate that all three lead to an approximately scale-invariant spectrum of cosmological perturbations.Comment: 45 pages, 10 figures; invited lectures at the 6th Aegean Summer School "Quantum Gravity and Quantum Cosmology", Chora, Naxos, Greece, Sept. 12 - 17 2012, to be publ. in the proceedings; these lecture notes form an updated version of arXiv:1003.1745 and arXiv:1103.227

Observation of Tau Neutrino Interactions

The DONUT experiment has analyzed 203 neutrino interactions recorded in nuclear emulsion targets. A decay search has found evidence of four tau neutrino interactions with an estimated background of 0.34 events. This number is consistent with the Standard Model expectation.Comment: 12 pages, 3 figures, PD

On the contact detection for contact-impact analysis in multibody systems

One of the most important and complex parts of the simulation of multibody systems with contact-impact involves the detection of the precise instant of impact. In general, the periods of contact are very small and, therefore, the selection of the time step for the integration of the time derivatives of the state variables plays a crucial role in the dynamics of multibody systems. The conservative approach is to use very small time steps throughout the analysis. However, this solution is not efficient from the computational view point. When variable time step integration algorithms are used and the pre-impact dynamics does not involve high-frequencies the integration algorithms may use larger time steps and the contact between two surfaces may start with initial penetrations that are artificially high. This fact leads either to a stall of the integration algorithm or to contact forces that are physically impossible which, in turn, lead to post-impact dynamics that is unrelated to the physical problem. The main purpose of this work is to present a general and comprehensive approach to automatically adjust the time step, in variable time step integration algorithms, in the vicinity of contact of multibody systems. The proposed methodology ensures that for any impact in a multibody system the time step of the integration is such that any initial penetration is below any prescribed threshold. In the case of the start of contact, and after a time step is complete, the numerical error control of the selected integration algorithm is forced to handle the physical criteria to accept/reject time steps in equal terms with the numerical error control that it normally uses. The main features of this approach are the simplicity of its computational implementation, its good computational efficiency and its ability to deal with the transitions between non contact and contact situations in multibody dynamics. A demonstration case provides the results that support the discussion and show the validity of the proposed methodology.Fundação para a Ciência e a Tecnologia (FCT

Herschel/HIFI measurements of the ortho/para ratio in water towards Sagittarius B2(M) and W31C

We present Herschel/HIFI observations of the fundamental rotational transitions of ortho- and para-H16 2 O and H18 2 O in absorption towards Sagittarius B2(M) and W31C. The ortho/para ratio in water in the foreground clouds on the line of sight towards these bright continuum sources is generally consistent with the statistical high-temperature ratio of 3, within the observational uncertainties. However, somewhat unexpectedly, we derive a low ortho/para ratio of 2.35±0.35, corresponding to a spin temperature of ∼27 K, towards Sagittarius B2(M) at velocities of the expanding molecular ring. Water molecules in this region appear to have formed with, or relaxed to, an ortho/para ratio close to the value corresponding to the local temperature of the gas and dust

Global maps of soil temperature.

Research in global change ecology relies heavily on global climatic grids derived from estimates of air temperature in open areas at around 2 m above the ground. These climatic grids do not reflect conditions below vegetation canopies and near the ground surface, where critical ecosystem functions occur and most terrestrial species reside. Here, we provide global maps of soil temperature and bioclimatic variables at a 1-km <sup>2</sup> resolution for 0-5 and 5-15 cm soil depth. These maps were created by calculating the difference (i.e. offset) between in situ soil temperature measurements, based on time series from over 1200 1-km <sup>2</sup> pixels (summarized from 8519 unique temperature sensors) across all the world's major terrestrial biomes, and coarse-grained air temperature estimates from ERA5-Land (an atmospheric reanalysis by the European Centre for Medium-Range Weather Forecasts). We show that mean annual soil temperature differs markedly from the corresponding gridded air temperature, by up to 10°C (mean = 3.0 ± 2.1°C), with substantial variation across biomes and seasons. Over the year, soils in cold and/or dry biomes are substantially warmer (+3.6 ± 2.3°C) than gridded air temperature, whereas soils in warm and humid environments are on average slightly cooler (-0.7 ± 2.3°C). The observed substantial and biome-specific offsets emphasize that the projected impacts of climate and climate change on near-surface biodiversity and ecosystem functioning are inaccurately assessed when air rather than soil temperature is used, especially in cold environments. The global soil-related bioclimatic variables provided here are an important step forward for any application in ecology and related disciplines. Nevertheless, we highlight the need to fill remaining geographic gaps by collecting more in situ measurements of microclimate conditions to further enhance the spatiotemporal resolution of global soil temperature products for ecological applications