Design method for a reconfigurable mechanism for finger rehabilitation

This paper presents a design method for a reconfigurable single degree-of-freedom mechanism for robotic assisted finger therapy following a stroke. The mechanism is a four-bar linkage that in combination with variable link lengths is capable of reproducing a power grasp finger motion for a wide variety of finger sizes. This is accomplished through an optimization procedure that determines the parameters of the four-bar linkage needed to fit the sampled range of finger trajectories. The linkage is located behind the hand and attaches to the medial phalanx of the finger just above the distal interphalangeal joint. In addition, the mechanism is designed so that it does not interfere with finger motion and so that the subject‘s fingertips and palm are free to touch real objects and experience tactile feedback. In future implementations, the mechanism could be used for a single finger or in parallel with other similar mechanisms to exercise multiple fingers simultaneously. Although the specific application presented here is the four-bar mechanism and finger power grasp motion, the developed design methods may be applied to a much broader range of mechanisms and applications where scalability for human-machine interface is required.Postprint (published version

Low-Cost Substrates for High-Performance Nanorod Array LEDs

The completed project, entitled âLow-Cost Substrates for High-Performance Nanorod LEDs,â targeted the goal of a phosphor-free nanorod-based white LED with IQE > 50% across the spectrum from 450 nm to 600 nm on metallized silicon substrates. The principal achievements of this project included: ⢠Demonstration of (In,Ga)N nanopyramid heterostructures by a conventional OMVPE process. ⢠Verification of complete filtering of threading dislocations to yield dislocation-free pyramidal heterostructures. ⢠Demonstration of electroluminescence with a peak wavelength of ~600 nm from an (In,Ga)N nanopyramid array LED. ⢠Development of a reflective ZrN/AlN buffer layer for epitaxial growth of GaN films and GaN nanopyramid arrays on (111)Si

Changing the academic culture: Valuing patents and commercialization toward tenure and career advancement

There is national and international recognition of the importance of innovation, technology transfer, and entrepreneurship for sustained economic revival. With the decline of industrial research laboratories in the United States, research universities are being asked to play a central role in our knowledge-centered economy by the technology transfer of their discoveries, innovations, and inventions. In response to this challenge, innovation ecologies at and around universities are starting to change. However, the change has been slow and limited. The authors believe this can be attributed partially to a lack of change in incentives for the central stakeholder, the faculty member. The authors have taken the position that universities should expand their criteria to treat patents, licensing, and commercialization activity by faculty as an important consideration for merit, tenure, and career advancement, along with publishing, teaching, and service. This position is placed in a historical context with a look at the history of tenure in the United States, patents, and licensing at universities, the current status of university tenure and career advancement processes, and models for the future

Comparing bladder neck contracture rate between robotic intracorporeal and extracorporeal neobladder construction

Robot-assisted radical cystectomy (RARC) has become more accessible to surgeons worldwide, and descriptions of intracorporeal urinary diversion techniques, such as orthotopic neobladder construction, have increased. In this study, we aim to compare the rate of bladder neck contracture (BNC) formation between RARC and two different urinary diversion techniques. We retrospectively reviewed our institutional database for patients with bladder cancer who underwent RARC with intracorporeal neobladder (ICNB) construction (n = 11) or extracorporeal neobladder (ECNB) construction (n = 11) between 2012 and 2020. BNC was defined by the need for an additional surgical procedure (e.g., dilatation, urethrotomy). Patients who underwent RARC with ICNB (n = 11) were compared to patients who underwent RARC with ECNB (n = 11) across patient characteristics and postoperative BNC formation rates. Kaplan-Meier curves were generated for freedom from BNC based on the neobladder approach and compared with the log-rank test. For patients who received an ECNB, 73% (8/11) developed a BNC; in comparison, none of the patients in the ICNB group experienced a BNC. Kaplan-Meier survival analysis demonstrates the ECNB group\u27s median probability of freedom from BNC as 1.3 years, while the ICNB group was free of BNC over the study period (p \u3c 0.001). RARC with ICNB creation demonstrated a significantly reduced BNC rate in contrast to RARC with ECNB construction. Longer-term follow-up is needed to assess the durability of this difference in BNC rates

Using cfRNA as a tool to evaluate clinical treatment outcomes in patients with metastatic lung cancers and other tumors

Aim: We report an exploratory analysis of cfRNA as a biomarker to monitor clinical responses in non-small cell lung cancer (NSCLC), breast cancer, and colorectal cancer (CRC). An analysis of cfRNA as a method for measuring PD-L1 expression with comparison to clinical responses was also performed in the NSCLC cohort. Methods: Blood samples were collected from 127 patients with metastatic disease that were undergoing therapy, 52 with NSCLC, 50 with breast cancer, and 25 with CRC. cfRNA was purified from fractionated plasma, and following reverse transcription (RT), total cfRNA and gene expression of PD-L1were analyzed by real-time polymerase chain reaction (qPCR) using beta-actin expression as a surrogate for relative amounts of cfDNA and cfRNA. For the concordance study of liquid biopsies and tissue biopsies, the isolated RNA was analyzed by RNAseq for the expressions of 13 genes. We had to close the study early due to a lack of follow-up during the Covid-19 pandemic. Results: We collected a total of 373 blood samples. Mean cfRNA PCR signals after RT were about 50-fold higher than those of cfDNA. cfRNA was detected in all patients, while cfDNA was detected in 88% of them. A high concordance was found for the expression levels of 13 genes between blood and solid tumor tissue. Changes in cfRNA levels followed over the course of treatments were associated with response to therapy, increasing in progressive disease (PD) and falling when a partial response (PR) occurred. The expression of PD-L1 over time in patients treated with immunotherapy decreased with PR but increased with PD. Pre-treatment levels of PD-L1 were predictive of response in patients treated with immunotherapy. Conclusion: Changes in cfRNA correlate with clinical response to the therapy. Total cfRNA may be useful in predicting clinical outcomes. PD-L1 gene expression may provide a biomarker to predict response to PD-L1 inhibition

Efficacy and safety of tofacitinib dose de‐escalation and dose escalation for patients with ulcerative colitis: results from OCTAVE Open

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The Limits of International Law Symposium

Authors Jack L. Goldsmith and Eric A. Posner joined other top international law scholars in the fall of 2005 to discuss and critique The Limits of International Law, recently published by Oxford University Press

Final Design and On-Sky Testing of the iLocater SX Acquisition Camera: Broadband Single-Mode Fiber Coupling

Enabling efficient injection of light into single-mode fibers (SMFs) is a key requirement in realizing diffraction-limited astronomical spectroscopy on ground-based telescopes. SMF-fed spectrographs, facilitated by the use of adaptive optics (AO), offer distinct advantages over comparable seeing-limited designs, including higher spectral resolution within a compact and stable instrument volume, and a telescope independent spectrograph design. iLocater is an extremely precise radial velocity (EPRV) spectrograph being built for the Large Binocular Telescope (LBT). We have designed and built the front-end fiber injection system, or acquisition camera, for the SX (left) primary mirror of the LBT. The instrument was installed in 2019 and underwent on-sky commissioning and performance assessment. In this paper, we present the instrument requirements, acquisition camera design, as well as results from first-light measurements. Broadband single-mode fiber coupling in excess of 35% (absolute) in the near-infrared (0.97-1.31{\mu}m) was achieved across a range of target magnitudes, spectral types, and observing conditions. Successful demonstration of on-sky performance represents both a major milestone in the development of iLocater and in making efficient ground-based SMF-fed astronomical instruments a reality.Comment: 18 pages, 17 figures. Accepted for publication in MNRA

Riparian Research and Management: Past, Present, Future: Volume 1

Fifty years ago, riparian habitats were not recognized for their extensive and critical contributions to wildlife and the ecosystem function of watersheds. This changed as riparian values were identified and documented, and the science of riparian ecology developed steadily. Papers in this volume range from the more mesic northwestern United States to the arid Southwest and Mexico. More than two dozen authors—most with decades of experience—review the origins of riparian science in the western United States, document what is currently known about riparian ecosystems, and project future needs. Topics are widespread and include: interactions with fire, climate change, and declining water; impacts from exotic species; unintended consequences of biological control; the role of small mammals; watershed response to beavers; watershed and riparian changes; changes below large dams; water birds of the Colorado River Delta; and terrestrial vertebrates of mesquite bosques. Appendices and references chronicle the field’s literature, authors, “riparian pioneers,” and conferences