Delay in Diagnosis of Intestinal Obstruction in a Patient with Familial Mediterranean Fever

Familial Mediterranean Fever (FMF) is a recurrent disease characterized by inflammatory process effecting synovial membranes such as peritoneum, pericardium and joints. It usually presents with acute abdominal pain. Intestinal obstruction secondary to adhesions may be observed in FMF patients. Sometimes diagnosing intestinal obstruction can be a challenging problem. We were presented a patient with FMF and adhesive intestinal obstruction. He was operated on after 10 days of symptoms. Delay in diagnosis and treatment of the case discussed with literature review

Paraoxonase and Arylesterase Activities, Lipid Profile, and Oxidative Damage in Experimental Ischemic Colitis Model

Objective. In the present study, since PON1 is known as an HDL-associated antioxidant enzyme that inhibits the oxidative modification of LDL and oxidative stress plays a role in the pathogenesis of mesenteric ischemia, we investigated the changes in PON1 activity and lipid profile in an experimental ischemic colitis model. Methods. Forty male Wistar albino rats were divided into two groups: the control group (N = 15) and the experimental group (N = 25). All animals were anesthetized with ether and ketamine anesthesia to undergo a midline laparotomy. Ischemic colitis was induced by marginal vessel ligation in the splenic flexura (devascularization process). A sham laparotomy was performed in the control group. All animals were sacrificed on the seventh postoperative day. Oxidative stress marker (malonyldialdehyde, MDA), lipid profile, and paraoxonase (PON-1) and arylesterase activities were determined. Histopathological evaluation was done under light microscopy, after sectioning and staining with hematoxyline and eosin. Statistical analysis was conducted using Student's t-test and Mann-Whitney U test, and P 0.05).Conclusions. PON1 and arylesterase play an important role in the pathophysiology of ischemic colitis

Real-World Outcomes of Anti-VEGF Treatment for Neovascular Age-Related Macular Degeneration in Turkey: A Multicenter Retrospective Study, Bosphorus Retina Study Group Report No: 1

Objectives: To evaluate the real-world outcomes of intravitreal anti-vascular endothelial growth factor (anti-VEGF) treatment in neovascular age-related macular degeneration (nAMD) patients. Materials and Methods: Multicenter, retrospective, interventional, non-comparative study. The records of nAMD patients treated with an anti-VEGF agent on a pro re nata treatment regimen basis between January 2013 and December 2015 were reviewed. The patients who completed a follow-up period of 12 months were included. Primary outcome measures of this study were the visit and injection numbers during the first year. Results: Eight hundred eighty eyes of 783 patients met the inclusion criteria for the study. Mean number of visits at month 12 was 6.9±2.5 (range: 1-15). Mean number of injections at month 12 was 4.1±1.9 (range: 1-11). Mean visual acuity at baseline and months 3, 6, and 12 was 0.90±0.63 LogMAR (range: 0.0-3.0), 0.79±0.57 LogMAR (range: 0.0-3.0), 0.76±0.57 LogMAR (range: 0.0-3.0), and 0.79±0.59 LogMAR (range: 0.0-3.0), respectively. Mean central retinal thickness at baseline and months 6 and 12 was 395±153 μm (range: 91-1582), 330±115 μm (range: 99-975), and 332±114 μm (range: 106-1191), respectively. Conclusion: The numbers of visits and injections were much lower than ideal and were insufficient with the pro re nata treatment regimen

The value of inflammatorymarkers and biochemicalparameters in assessment of severityof acute pancreatitis

AMAÇ : Akut pankreatit hala önemli bir patolojidir. Bu çalışmamızda akut pankreatit nedeni ile tedavi ettiğimiz hastalarda ciddi pankreatit gelişimine gösterebilecek inflamatuar markırlar ve bio- kimyasal parametreler retrospektif olarak ince- lendi. GEREÇ VE YÖNTEM : Mayıs 2011 ile Ekim 2011 tarihleri arsında akut pankreatit tanısı alan 52 hasta retrospektif olarak incelendi. Hastalar BTciddiyet indeksine göre hafif ve ciddi pankreatit olarak 2 gruba ayrıldı . Hastaların yaş,cinsiyet, Laboratuar ve görüntüleme yöntemlerinin sonuçları, ,hastanede yatış süreleri, morbidite ve mortalite sonuçları toplandı. Sonuçlar SPSS 17 istatstik programında değerlendirildi. BULGULAR: Retrospektif olarak incelenen52 hastanın 39u kadın ve 13ü erkekti. Hastaların yaş ortalaması 56.817.2 (19-97 arası) idi. Hastaların 30u hafif (BTindeksi A-B- C), 22si ciddi (BTindeksi D-E) olarak sınıflandırıldı. CRPdeğerleri ciddi pankreatit grubunda daha yüksek olmasına rağmen istatistiksel olarak anlamlı değildi. Ağır pankreatit grubunda Lökosit sayısı ve serum glukoz değerleri hafif pankreatit grubuna göre istatistiksel olarak anlamlı derecede yüksek olarak bulundu. ( p 0.006 ve p 0.009). SONUÇLAR: Bu çalışma ciddi pankreatitli hasta grubunda lökosit sayımı ve kan şeker düzeylerinin hafif pankreatitli hastalara göre anlamlı olarak yüksek seyrettiğini göstermiştir. Bu laboratuar testleri pankreatitli hastaların prognozunu balirlemede yardımcı olabilir.OBJECTİVE : Acute pancreatitis is still an important pathology. In this study, we analyzed retros- pectively the predictive value of inflammatory markers and biochemical parameters for developement of severe pancreatitis. METHODS: Fifty-two patients with diagnosis of acute pancreatitis were retrospectively studied in between May 2011 to October 2011.The patients were separated in two groups according to CTseverity indexs as mild and severe pancreatitis. Data about patients age,gender, laboratory and imaging results ,duration of hospitalization, morbidity and mortality rates were collected. The statistical analysis was performed with SPSS 17 program. RESULTS: There were 39 women and 13 men patients. The median age was 56.8±17.2 (Ran- ge:19-97). There were 30 mild and 22 severe pancreatitis. Although CRPvalue was higher in severe pancreatitis it was not statistically meaningful. The leucocyte count and gluco- se level were statistically higher in severe pancreatitis group (p value0.006 and p value0.009 respectively) CONCLUSION : This study demonstrated that leucocyte cound and glucose level can be predictive laboratory tests for severe pancreatitis