The developmental course of illicit substance use from age 12 to 22: links with depressive, anxiety, and behavior disorders at age 18

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72027/1/j.1469-7610.2008.01915.x.pd

Peer Victimization and Neurobiological Models: Building Toward Comprehensive Developmental Theories

The articles in this special issue represent progress toward a more comprehensive developmental model of peer victimization and neurobiology. In this commentary, we highlight features of each article that reveal nuances in such a developmental model as related to sex, form of peer victimization, developmental course and period, and neurobiological response system and stimulus. We also encourage further research with an emphasis on longitudinal studies that cross developmental periods and elucidate directions of causality and mechanisms of change, expanded attention to individual and environmental variables that may explain or contextualize effects, assessments of multiple neurobiological systems, and tests of replication, as well as innovation. We acknowledge the challenges of such research and thank the authors for their important contributions to the literature on peer victimization and neurobiology

Neurophysiological differences in the adolescent brain following a single night of restricted sleep – A 7T fMRI study

Sleep deprivation in youth has garnered international attention in recent years, as correlational studies have demonstrated significant relationships between lack of sleep and detrimental behavioral and academic outcomes. However, no study to date has systematically examined the neurophysiological consequences of a single night of sleep restriction (i.e., 4 h) in adolescents using ultra-high field functional neuroimaging. Much of what we know regarding the neural consequences of sleep deprivation has come from the adult literature, and among those studies, the majority use region of interest (ROI) approaches, thus disregarding the dynamic mechanisms that may subserve the behavioral effects of sleep restriction. Leveraging a crossover within-subjects design, we demonstrate that pivotal brain regions involved in the default mode and limbic regulatory centers have disrupted functioning following a night of restricted sleep compared to a night of “normal sleep”. Specifically, a normal night (i.e., 8 h) of sleep led to increased global and local efficiency of bilateral amygdala, and less efficiency in the posterior cingulate, as measured by graph theory, compared to a night of sleep restriction. Furthermore, aberrant functional connectivity patterns were identified in key fronto-limbic circuitry, suggesting a potential pathophysiological mechanism underlying the widespread effects of sleep deprivation in youth

Longitudinal relations between maternal depressive symptoms and child sleep problems: the role of parasympathetic nervous system reactivity.

BackgroundWe examined maternal depressive symptoms (MDS) as longitudinal predictors of actigraphy-measured sleep; children's respiratory sinus arrhythmia (RSA) was tested as a moderator of these relations.MethodA total of 271 children (145 boys and 126 girls) participated in a three-wave study (M age at T1 = 9.38 years), with a 1-year lag between waves. Children wore actigraphs to derive sleep parameters. RSA reactivity was assessed during a social stress test.ResultsContrary to hypotheses, MDS were related to less sleep over time for children exhibiting greater RSA withdrawal. Consistent with hypotheses, MDS were related longitudinally to decreased sleep activity for children exhibiting less RSA withdrawal.ConclusionsFindings illustrate the importance of maternal influences and physiological regulation as predictors of children's sleep