Distribution of AMD by presence or absence of previous cataract surgery.

<p>Data presented are no. (%). Analysis was done on eye level.</p><p>^a<i>P</i> values are for 2x2 comparisons between pseudophakic/aphakic eyes vs. phakic eyes, 1 degree of freedom chi-square test.</p><p>Distribution of AMD by presence or absence of previous cataract surgery.</p

Joint effects of lens status and <i>CFH/ARMS2</i> SNP on risk of early AMD and any AMD.

<p>OR, odds ratio; CI, confidence interval.</p><p>^a Odds ratios were calculated using multivariate logistic regression using general estimating equations, adjusted for age, gender and the first 5 genetic principal components.</p><p>^b<i>P</i> <0.05</p><p>^c<i>P</i> <0.01</p><p>^d<i>P</i>-value of the interaction term β_GE GE was used to assess the significance of the interaction between lens status and genetic variants.</p><p>Joint effects of lens status and <i>CFH/ARMS2</i> SNP on risk of early AMD and any AMD.</p

Characteristics of subjects without AMD, with early AMD and with any AMD.

<p>Data presented are no. (%), except for age, which is presented as mean (SD). Analysis was done by individual level.</p><p>^a Number of subjects with missing data for the following variables: current smokers, 8; hypertension, 20; diabetes, 55; hyperlipidaemia, 61; chronic kidney disease, 1.</p><p>^b For comparison between individuals without AMD vs with early AMD, using chi-square tests for categorical variables, and two sample t-tests for continuous variables.</p><p>^c For comparison between individuals without AMD vs with any AMD, using chi-square tests for categorical variables, and two sample t-tests for continuous variables.</p><p>Characteristics of subjects without AMD, with early AMD and with any AMD.</p

Multivariate analysis showing the association of AMD with lens status, and the <i>CFH</i> and <i>ARMS</i>2 SNPs.

<p>OR, odds ratio; CI, confidence interval.</p><p>^aMultivariate logistic regression using general estimating equations, adjusted for age, gender, and ethnicity for the effect of lens status, and additionally adjusted for the first 5 genetic principal components for the effects of SNPs.</p><p>^bAdjusted for the covariates in Model 1 and current smoker, hypertension, diabetes, hyperlipidaemia, and chronic kidney disease.</p><p>Multivariate analysis showing the association of AMD with lens status, and the <i>CFH</i> and <i>ARMS</i>2 SNPs.</p

Association analysis between <i>ABCC5</i> rs1401999 and primary angle closure glaucoma in all chip-typed sample collections (top panel), de-novo genotyped sample collections (middle panel), and PACG cases and clinically certified controls with open angles (bottom panel).

<p>MAF case: Minor allele frequency in PACG cases.</p><p>MAF control: Minor allele frequency in controls.</p><p>OR: Odds ratio.</p><p><i>P</i>: <i>P</i>-value for association with PACG.</p><p>I²: I-squared index for between-collection heterogeneity.</p><p>* Results here are presented based on raw minor allele frequency counts without further adjustment.</p>†<p>PACG patients were recruited from the Beijing Tongren Hospital and controls were recruited from the Handan Eye Study (HES), a population-based study of eye disease in rural Chinese aged 30 years and over.</p

Association analysis between <i>ABCC5</i> rs1401999 and susceptibility to primary angle closure glaucoma (PACG).

<p>The PACG sample collections have been described elsewhere <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1004089#pgen.1004089-Vithana1" target="_blank">[6]</a>. The vertical line represents a per-allele odds ratio of 1.00. The oblongs represent point estimates (referring to the per-allele odds ratio), with the height of the oblongs inversely proportional to the standard error of the point estimates. Horizontal lines indicate the 95% confidence interval for each point estimate. Meta-analyses of samples are reflected by blue diamonds. The width of the diamonds indicates their 95% confidence intervals. All point estimates in Stage 1 have been adjusted for the top axes of genetic stratification using logistic regression.</p

Quantitative trait analysis between <i>ABCC5</i> rs1401999 and anterior chamber depth in SIMES, SINDI, and BES.

<p>SIMES: Singapore Malay Eye Study (typed with Illumina 610K GWAS chip).</p><p>SINDI: Singapore Indian Eye Study (typed with Illumina 610K GWAS chip).</p><p>BES1: Beijing Eye Study typed with Illumina 610K GWAS chip.</p><p>BES2: Beijing Eye Study typed with direct sequencing.</p><p>β: Per-allele effect size of <i>ABCC5</i> rs1401999 on anterior chamber depth.</p><p>SE: Standard error for β.</p><p><i>P</i>gc: Genomic control corrected <i>P</i>-value.</p><p>MAF: Minor allele frequency.</p><p>*: I²-index for heterogeneity = 0%.</p