17,999 research outputs found
On the Stability of Gas Bubbles in Liquid-Gas Solutions
With the neglect of the translational motion of the bubble, approximate solutions may be found for the rate of solution by diffusion of a gas bubble in an undersaturated liquid-gas solution; approximate solutions are also presented for the rate of growth of a bubble in an oversaturated liquid-gas solution. The effect of surface tension on the diffusion process is also considered
Ferrite post in a rectangular wave guide
A thin circular ferrite post magnetized lengthwise is placed in a rectangular wave guide with its axis normal to the direction of propagation of the incident waves. The polarization is such that the electric vector is parallel to the post. The reflected and transmitted waves are calculated both with respect to their intensities and phases. The results are also applied to find the influence of a thin ferrite post upon the resonant frequency of a rectangular cavity
Socially Optimal Mining Pools
Mining for Bitcoins is a high-risk high-reward activity. Miners, seeking to
reduce their variance and earn steadier rewards, collaborate in pooling
strategies where they jointly mine for Bitcoins. Whenever some pool participant
is successful, the earned rewards are appropriately split among all pool
participants. Currently a dozen of different pooling strategies (i.e., methods
for distributing the rewards) are in use for Bitcoin mining.
We here propose a formal model of utility and social welfare for Bitcoin
mining (and analogous mining systems) based on the theory of discounted
expected utility, and next study pooling strategies that maximize the social
welfare of miners. Our main result shows that one of the pooling strategies
actually employed in practice--the so-called geometric pay pool--achieves the
optimal steady-state utility for miners when its parameters are set
appropriately.
Our results apply not only to Bitcoin mining pools, but any other form of
pooled mining or crowdsourcing computations where the participants engage in
repeated random trials towards a common goal, and where "partial" solutions can
be efficiently verified
A Robust AFPTAS for Online Bin Packing with Polynomial Migration
In this paper we develop general LP and ILP techniques to find an approximate
solution with improved objective value close to an existing solution. The task
of improving an approximate solution is closely related to a classical theorem
of Cook et al. in the sensitivity analysis for LPs and ILPs. This result is
often applied in designing robust algorithms for online problems. We apply our
new techniques to the online bin packing problem, where it is allowed to
reassign a certain number of items, measured by the migration factor. The
migration factor is defined by the total size of reassigned items divided by
the size of the arriving item. We obtain a robust asymptotic fully polynomial
time approximation scheme (AFPTAS) for the online bin packing problem with
migration factor bounded by a polynomial in . This answers
an open question stated by Epstein and Levin in the affirmative. As a byproduct
we prove an approximate variant of the sensitivity theorem by Cook at el. for
linear programs
Autocatalytic plume pinch-off
A localized source of buoyancy flux in a non-reactive fluid medium creates a
plume. The flux can be provided by either heat, a compositional difference
between the fluid comprising the plume and its surroundings, or a combination
of both. For autocatalytic plumes produced by the iodate-arsenous acid
reaction, however, buoyancy is produced along the entire reacting interface
between the plume and its surroundings. Buoyancy production at the moving
interface drives fluid motion, which in turn generates flow that advects the
reaction front. As a consequence of this interplay between fluid flow and
chemical reaction, autocatalytic plumes exhibit a rich dynamics during their
ascent through the reactant medium. One of the more interesting dynamical
features is the production of an accelerating vortical plume head that in
certain cases pinches-off and detaches from the upwelling conduit. After
pinch-off, a new plume head forms in the conduit below, and this can lead to
multiple generations of plume heads for a single plume initiation. We
investigated the pinch-off process using both experimentation and simulation.
Experiments were performed using various concentrations of glycerol, in which
it was found that repeated pinch-off occurs exclusively in a specific
concentration range. Autocatalytic plume simulations revealed that pinch-off is
triggered by the appearance of accelerating flow in the plume conduit.Comment: 10 figures. Accepted for publication in Phys Rev E. See also
http://www.physics.utoronto.ca/nonlinear/papers_chemwave.htm
Limit cycles in the presence of convection, a travelling wave analysis
We consider a diffusion model with limit cycle reaction functions, in the
presence of convection. We select a set of functions derived from a realistic
reaction model: the Schnakenberg equations. This resultant form is
unsymmetrical. We find a transformation which maps the irregular equations into
model form. Next we transform the dependent variables into polar form. From
here, a travelling wave analysis is performed on the radial variable. Results
are complex, but we make some simple estimates.
We carry out numerical experiments to test our analysis. An initial `knock'
starts the propagation of pattern. The speed of the travelling wave is not
quite as expected. We investigate further. The system demonstrates distinctly
different behaviour to the left and the right. We explain how this phenomenon
occurs by examining the underlying behaviour.Comment: 20 pages, 5 figure
The C_2 heat-kernel coefficient in the presence of boundary discontinuities
We consider the heat-kernel on a manifold whose boundary is piecewise smooth.
The set of independent geometrical quantities required to construct an
expression for the contribution of the boundary discontinuities to the C_{2}
heat-kernel coefficient is derived in the case of a scalar field with Dirichlet
and Robin boundary conditions. The coefficient is then determined using
conformal symmetry and evaluation on some specific manifolds. For the Robin
case a perturbation technique is also developed and employed. The contributions
to the smeared heat-kernel coefficient and cocycle function are calculated.
Some incomplete results for spinor fields with mixed conditions are also
presented.Comment: 25 pages, LaTe
PDE8 controls CD4(+) T cell motility through the PDE8A-Raf-1 kinase signaling complex
The levels of cAMP are regulated by phosphodiesterase enzymes (PDEs), which are targets for the treatment of inflammatory disorders. We have previously shown that PDE8 regulates T cell motility. Here, for the first time, we report that PDE8A exerts part of its control of T cell function through the V-raf-1 murine leukemia viral oncogene homolog 1 (Raf-1) kinase signaling pathway. To examine T cell motility under physiologic conditions, we analyzed T cell interactions with endothelial cells and ligands in flow assays. The highly PDE8-selective enzymatic inhibitor PF-04957325 suppresses adhesion of in vivo myelin oligodendrocyte glycoprotein (MOG) activated inflammatory CD4(+) T effector (Teff) cells to brain endothelial cells under shear stress. Recently, PDE8A was shown to associate with Raf-1 creating a compartment of low cAMP levels around Raf-1 thereby protecting it from protein kinase A (PKA) mediated inhibitory phosphorylation. To test the function of this complex in Teff cells, we used a cell permeable peptide that selectively disrupts the PDE8A-Raf-1 interaction. The disruptor peptide inhibits the Teff-endothelial cell interaction more potently than the enzymatic inhibitor. Furthermore, the LFA-1/ICAM-1 interaction was identified as a target of disruptor peptide mediated reduction of adhesion, spreading and locomotion of Teff cells under flow. Mechanistically, we observed that disruption of the PDE8A-Raf-1 complex profoundly alters Raf-1 signaling in Teff cells. Collectively, our studies demonstrate that PDE8A inhibition by enzymatic inhibitors or PDE8A-Raf-1 kinase complex disruptors decreases Teff cell adhesion and migration under flow, and represents a novel approach to target T cells in inflammation
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