294 research outputs found
Cell separation using electric fields
The present invention involves methods and devices which enable discrete objects having a conducting inner core, surrounded by a dielectric membrane to be selectively inactivated by electric fields via irreversible breakdown of their dielectric membrane. One important application of the invention is in the selection, purification, and/or purging of desired or undesired biological cells from cell suspensions. According to the invention, electric fields can be utilized to selectively inactivate and render non-viable particular subpopulations of cells in a suspension, while not adversely affecting other desired subpopulations. According to the inventive methods, the cells can be selected on the basis of intrinsic or induced differences in a characteristic electroporation threshold, which can depend, for example, on a difference in cell size and/or critical dielectric membrane breakdown voltage. The invention enables effective cell separation without the need to employ undesirable exogenous agents, such as toxins or antibodies. The inventive method also enables relatively rapid cell separation involving a relatively low degree of trauma or modification to the selected, desired cells. The inventive method has a variety of potential applications in clinical medicine, research, etc., with two of the more important foreseeable applications being stem cell enrichment/isolation, and cancer cell purging
Rate Measurement of and Constraints on Mixing
We present an observation and rate measurement of the decay D0 -> K+pi-pi0
produced in 9/fb of e+e- collisions near the Upsilon(4S) resonance. The signal
is inconsistent with an upward fluctuation of the background by 4.9 standard
deviations. We measured the rate of D0 -> K+pi-pi0 normalized to the rate of
D0bar -> K+pi-pi0 to be 0.0043 +0.0011 -0.0010 (stat) +/- 0.0007 (syst). This
decay can be produced by doubly-Cabibbo-suppressed decays or by the D0 evolving
into a D0bar through mixing, followed by a Cabibbo-favored decay to K+pi-pi0.
We also found the CP asymmetry A=(8 +25 -22)% to be consistent with zero.Comment: 10 pages postscript, also available through
http://w4.lns.cornell.edu/public/CLN
First Observation of barB0 to D*0 pi+pi+pi-pi- Decays
We report on the observation of B0bar -> D*0 pi+ pi+ pi- pi- decays. The
branching ratio is (0.30 +/- 0.07 +/- 0.06)%. Interest in this particular mode
was sparked by Ligeti, Luke and Wise who propose it as a way to check the
validity of factorization tests in B0bar -> D*+ pi+ pi- pi- pi0 decays.Comment: 11 pages postscript, also available through
http://w4.lns.cornell.edu/public/CLNS, Version to appear in Phys. Rev.
A Search for Charmless Decays
We have studied two-body charmless decays of the meson into the final
states , , , , , , and
using only decay modes with charged daughter particles. Using 9.7 million pairs collected with the CLEO detector, we place 90% confidence level
upper limits on the branching fractions, , depending
on final state and polarization.Comment: 8 pages postscript, also available through
http://w4.lns.cornell.edu/public/CLN
Search for a Scalar Bottom Quark with Mass 3.5-4.5 GeV/
We report on a search for a supersymmetric meson with mass
between 3.5 and 4.5 GeV/ using 4.52 of integrated
luminosity produced at GeV, just below the threshold, and collected with the CLEO detector. We find no evidence
for a light scalar bottom quark.Comment: 10 pages postscript, also available through
http://w4.lns.cornell.edu/public/CLN
Observation of New States Decaying into
Using 13.7 fb^{-1} of data recorded by the CLEO detector at CESR, we
investigate the spectrum of charmed baryons which decay into Lambda_c^+ pi^-
pi^+ and are more massive than the Lambda_{c1} baryons. We find evidence for
two new states: one is broad and has an invariant mass roughly 480 MeV above
that of the Lambda_c^+; the other is narrow with an invariant mass of 596 +- 1
+- 2 MeV above the Lambda_c^+ mass. These results are preliminary.Comment: 11 pages postscript, also available through
http://w4.lns.cornell.edu/public/CLN
Correlated /\c-/\cbar production in e+e- annihilations at sqrt{s}~10.5 GeV
Using 13.6/fb of continuum two-jet e+e- -> ccbar events collected with the
CLEO detector, we have searched for baryon number correlations at the primary
quark level. We have measured the likelihood for a /\c+ charmed baryon to be
produced in the hemisphere opposite a /\c- relative to the likelihood for a
/\c+ charmed baryon to be produced opposite an anticharmed meson Dbar; in all
cases, the reconstructed hadrons must have momentum greater than 2.3 GeV/c. We
find that, given a /\c- (reconstructed in five different decay modes), a /\c+
is observed in the opposite hemisphere (0.72+/-0.11)% of the time (not
corrected for efficiency). By contrast, given a Dbar in one hemisphere, a /\c+
is observed in the opposite hemisphere only (0.21+/-0.02)% of the time.
Normalized to the total number of either /\c- or Dbar ``tags'', it is therefore
3.52+/-0.45+/-0.42 times more likely to find a /\c+ opposite a /\c- than a Dbar
meson. This enhancement is not observed in the JETSET 7.3 e+e- -> ccbar Monte
Carlo simulation.Comment: 19 pages, Latex, one figure separat
Hadronic Mass Moments in Inclusive Semileptonic B Meson Decays
We have measured the first and second moments of the hadronic mass-squared
distribution in B -> X_c l nu, for P(lepton) > 1.5 GeV/c. We find <M_X^2 -
M_D[Bar]^2> = 0.251 +- 0.066 GeV^2, )^2 > = 0.576 +- 0.170
GeV^4, where M_D[Bar] is the spin-averaged D meson mass.
From that first moment and the first moment of the photon energy spectrum in
b -> s gamma, we find the HQET parameter lambda_1 (MS[Bar], to order 1/M^3 and
beta_0 alpha_s^2) to be -0.24 +- 0.11 GeV^2. Using these first moments and the
B semileptonic width, and assuming parton-hadron duality, we obtain |V_cb| =
0.0404 +- 0.0013.Comment: 11 pages postscript, also available through
http://w4.lns.cornell.edu/public/CLNS, submitted to PR
Bounds on the CP Asymmetry in Like-Sign Dileptons from Meson Decays
We have measured the charge asymmetry in like-sign dilepton yields from B^0
B^0-bar meson decays using the CLEO detector at the Cornell Electron Storage
Ring. We find a_ll = [N(l+l+) - N(l-l-)]/[N(l+l+) + N[l-l-)] = +0.013 +/- 0.050
+/- 0.005 . We combine this result with a previous, independent measurement and
obtain Re(epsilon_B)/(1+|epsilon_B|^2) = +0.0035 +/- 0.0103 +/- 0.0015
(uncertainties are statistical and systematic, respectively) for the CP
impurity parameter, epsilon_B.Comment: 11 pages postscript, also available through
http://w4.lns.cornell.edu/public/CLN
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