Association analysis of drug metabolizing enzyme gene polymorphisms in AIDS patients with cutaneous reactions to sulfonamides

Variation in the bioactivation and the detoxification may determine the susceptibility of AIDS patients to cutaneous reactions to sulfonamides. We undertook a genotyping study to evaluate glutathione S-transferase P1, cytochrome P450 2C9, NAD(P)H: quinone oxidoreductase, and myeloperoxidase genetic polymorphism as risk factors. One hundred and thirty-six AIDS patients treated with sulfonamides were prospectively followed up. Patients with and without a cutaneous drug reactions were compared as a function of their genotype. To increase the power of study, we pooled our data with those of a similar study. We identified in the pooled data a significant association between sulfonamides cutaneous reactions and glutathione S-transferase P1* A/A compared with glutathione S-transferase P1* A/B and B/B (p=0.003). To conclude, most of the polymorphisms in drug metabolism investigated do not act as predisposing factors for sulfonamides reactions. The role of glutathione S-transferase P1 variants requires further in vitro and in vivo studies