CloudSafe: A tool for an automated security analysis for cloud computing

Cloud computing has been adopted widely, providing on-demand computing resources to improve performance and reduce operational costs. However, these new functionalities also bring new ways to exploit the cloud computing environment. To assess the security of the cloud, graphical security models can be used, such as Attack Graphs and Attack Trees. However, existing models do not consider all types of threats, and also automating the security assessment functions are difficult. In this paper, we propose a new security assessment tool for the cloud named CloudSafe, an automated security assessment for the cloud. The CloudSafe tool collates various tools and frameworks to automate the security assessment process. To demonstrate the applicability of the CloudSafe, we conducted security assessment in Amazon AWS, where our experimental results showed that we can effectively gather security information of the cloud and carry out security assessment to produce security reports. Users and cloud service providers can use the security report generated by the CloudSafe to understand the security posture of the cloud being used/provided. - 2019 IEEE.This paper was made possible by Grant NPRP 8-531-1-111 from Qatar National Research Fund (QNRF). The statements made herein are solely the responsibility of the authors.Scopu

Deciphering osteoarthritis genetics across 826,690 individuals from 9 populations

Osteoarthritis affects over 300 million people worldwide. Here, we conduct a genome-wide association study meta-analysis across 826,690 individuals (177,517 with osteoarthritis) and identify 100 independently associated risk variants across 11 osteoarthritis phenotypes, 52 of which have not been associated with the disease before. We report thumb and spine osteoarthritis risk variants and identify differences in genetic effects between weight-bearing and non-weight-bearing joints. We identify sex-specific and early age-at-onset osteoarthritis risk loci. We integrate functional genomics data from primary patient tissues (including articular cartilage, subchondral bone, and osteophytic cartilage) and identify high-confidence effector genes. We provide evidence for genetic correlation with phenotypes related to pain, the main disease symptom, and identify likely causal genes linked to neuronal processes. Our results provide insights into key molecular players in disease processes and highlight attractive drug targets to accelerate translation. © 2021 The Author