acne ra 1 2 a novel uv selective face cream for patients with acne efficacy and tolerability results of a randomized placebo controlled clinical study

SummaryBackground General skincare measures such as the use of moisturisers and products containing adequate photoprotection are important components of acne patients' management to complement the pharmacological regimen. Acne RA-1,2 is a novel dermato-cosmetic product which contains selective photofilters and active ingredients against the multifactorial pathophysiology of acne. Objectives To evaluate the tolerability of Acne RA-1,2 and its effect on the clinical signs of acne. Methods This double-blind, placebo-controlled study randomized 40 adult patients with 10-25 comedones per half face to once-daily application of Acne RA-1,2 or placebo for 8 weeks. Evaluations after 4 and 8 weeks included the number of comedones, transepidermal water loss (TEWL), sebum production, and tolerability. Results In the Acne RA-1,2 group, there was a significant 35% decrease in the mean number of comedones from 26 at baseline to 17 at Week 8 (P<.001), a 7% significant reduction in TEWL (9.32 to 8.66 g/h/m2; P<.001), and a 24% significant reduction in sebum production (154.8 to 117.6 μg/cm2; P<.001). The reductions in TEWL and sebum production were significantly greater than those in the placebo group at Weeks 4 and 8 (P<0.05). There were no adverse events. Conclusions Acne RA-1,2 was well tolerated and effective at reducing comedones and sebum production and improving epidermal barrier function. These results suggest that Acne RA-1,2 is useful against acne-prone facial skin, particularly as it targets sebum production, which topical pharmacological acne therapies do not address

Efficacy of a Cosmetic Treatment in Decreasing the Mild-to-Moderate Atopic Dermatitis in Babies, Children, and Adults: A Pilot Study

Atopic dermatitis (AD) is a chronic inflammatory and pruritic skin disease with a worldwide progressive increase in its incidence. In this clinical study, we studied the effect of a cosmetic treatment composed of a cleanser, and a body and face cream, on subjects (babies, children, and adults) suffering from mild-to-moderate AD. The product effect on AD clinical signs was investigated by SCORing Atopic Dermatitis (SCORAD) index, subjective evaluation, skin erythema index, and transepidermal water loss (TEWL) measurements. The products were shown to be effective in improving the AD scoring by SCORAD in all the groups, and a trend towards the decrease of the erythema index and the TEWL in the adult population. An improvement in itching sensation, skin redness, and skin dryness scoring was also reported by the subjects. Results from this study demonstrate the efficacy of the tested products in decreasing the overall AD severity through 28 days of treatment. Overall, the first results occurred within 14 days of treatment

Improving Skin Hydration and Age-related Symptoms by Oral Administration of Wheat Glucosylceramides and Digalactosyl Diglycerides: A Human Clinical Study

Ceramides are known to play a key role in the skin’s barrier function. An age-dependent decrease in ceramides content correlates with cutaneous clinical signs of dryness, loss of elasticity, and increased roughness. The present placebo-controlled clinical study aims to evaluate if an oral supplementation with glucosylceramides (GluCers) contained in a wheat polar lipids complex (WPLC) was able to improve such skin conditions. Sixty volunteers presenting dry and wrinkled skin were supplemented during 60 days with either a placebo or a WPLC extract in oil or powder form (1.7 mg GluCers and 11.5 mg of digalactosyldiglycerides (DGDG)). Skin parameters were evaluated at baseline and after 15, 30, and 60 days of supplementation. Oral intake of WPLC significantly increased skin hydration (p &lt; 0.001), elasticity, and smoothness (p &lt; 0.001), and decreased trans epidermal water loss (TEWL) (p &lt; 0.001), roughness (p &lt; 0.001), and wrinkledness (p &lt; 0.001) in both WPLC groups compared to placebo. In both WPLC treated groups, all parameters were significantly improved in a time-dependent manner compared to baseline. In conclusion, this study demonstrates the positive effect of oral supplementation with GluCers on skin parameters and could reasonably reinforce the observations made on mice that orally-supplied sphingolipids can reach the skin

Soothing Effect of a Cosmetic Product on Skin Discomforts Induced by a Chemical Irritant (Capsaicin) and UV-Radiation, and after Mosquito Bites and Sunburn in a Real-World Setting

Irritated and itchy skin is a common skin condition. Consumers tend to opt for natural ingredients for irritated skin (e.g., after insect bites or sun exposure). We tested a cosmetic product with 94% of its ingredients being of natural origin, each with its beneficial properties, e.g., nourishing shea butter, cooling menthol, and soothing bisabolol. Skin discomfort was induced either by a chemical irritant (capsaicin) or UV radiation by a solar simulator. In this clinical, prospective, and controlled experimental study, we investigated the soothing effect of the tested product. We observed a soothing effect on the capsaicin-induced itching and stinging sensation with a statistically significant decrease in the discomfort sensations one minute after a single application. The tested product also showed a significant reduction in the UV-induced skin erythema (UVA+B exposure). In a real-world study, these results can be correlated with a decrease of itching and irritation after sunburn or after insect bites

Dermoscopical and pathological findings in pseudoxanthoma elasticum-like papillary dermal elastolysis

Dermoscopical and pathological findings in pseudoxanthoma elasticum-like papillary dermal elastolysi

Antioxidant Efficacy of a Standardized Red Orange (<i>Citrus sinensis</i> (L.) Osbeck) Extract in Elderly Subjects: A Randomized, Double Blind, Controlled Study

The world population is rapidly aging. This should cause us to reflect on the need to develop a new nutritional approach to mitigate the accumulation of reactive oxygen species (ROS)-induced damage. A randomized, double blind, controlled study was carried out on 60 elderly male and female subjects. Product efficacy was measured before and after 2 and 8 weeks of product intake. The reduced (GSH) and oxidized (GSSG) glutathione concentrations in the erythrocytes and the reactive oxygen metabolites (d-ROMs) hematic concentration were measured to assess the antioxidant efficacy. The tumor necrosis factor-alpha (TNF-α) levels in the serum were measured to assess the anti-inflammatory effectiveness. The wellbeing was assessed by Short Form Health Survey (SF-36) questionnaire (male) and by Menopause Rating Scale (MRS) (female). Blood, urine analysis and electrocardiography (ECG) were carried out to assess the product’s safety. The results showed that GSH/GSSG ratio increased by 22.4% and 89.0% after 2 and 8 weeks of product intake. Serum TNF-α levels decreased by 2.5% after 8 weeks of product intake. The SF-36 QoL and the MRS questionnaire outputs indicate, preliminarily, a positive effect of the extract intake in ameliorating the wellbeing of both male and female subjects. The product was well-tolerated. Our findings suggest that the test product has antioxidant and anti-inflammatory efficacy and has a positive effect on the wellbeing of elderly female and male subjects

Skin Anti-Aging Efficacy of a Four-Botanical Blend Dietary Ingredient: A Randomized, Double Blind, Clinical Study

Plant polyphenols have been found to be effective in preventing or reducing different skin alterations. A dietary approach based on these compounds could be a safe and effective method to slow down or prevent age-associated deterioration of skin appearance and function. In a previous study, a specific combination of four botanical extracts (pomegranate, sweet orange, herba Cistanche, and Centella asiatica) exhibited potential anti-aging effects in a dermal fibroblast cell model. The present study aims to clinically evaluate the safety and anti-aging efficacy of this new botanical ingredient (eternalyoung&reg;). To this end, a 12-week randomized, double-blind, placebo-controlled study was carried out in 60 Caucasian women with evident signs of both chrono- and photoaging. Product efficacy was measured as follows: skin moisturization (corneometer), transepidermal water loss (tewameter), skin radiance, and color (spectrophotometer), skin elasticity and firmness (cutometer), skin roughness (image analysis), and skin thickness (ultrasound). Both intergroup and intragroup analysis proved that the daily intake of 225 mg of the active ingredient was enough to produce visible and structural improvements to the skin and to the signs of aging without any side effects. Statistically significant improvements compared to the placebo group were observed as early as 4 weeks regarding wrinkle depth, elasticity, firmness, skin thickness, skin moisturization, transepidermal water loss, and dark spots pigmentation. In addition, the subjects who consumed the blend reported better scores on the self-assessment questionnaires. Our results suggest that the intake of the test product can positively affect the appearance, barrier function, and skin density of aged skin after 12 weeks of treatment

Skin Anti-Aging Efficacy of a Four-Botanical Blend Dietary Ingredient: A Randomized, Double Blind, Clinical Study

Plant polyphenols have been found to be effective in preventing or reducing different skin alterations. A dietary approach based on these compounds could be a safe and effective method to slow down or prevent age-associated deterioration of skin appearance and function. In a previous study, a specific combination of four botanical extracts (pomegranate, sweet orange, herba Cistanche, and Centella asiatica) exhibited potential anti-aging effects in a dermal fibroblast cell model. The present study aims to clinically evaluate the safety and anti-aging efficacy of this new botanical ingredient (eternalyoung®). To this end, a 12-week randomized, double-blind, placebo-controlled study was carried out in 60 Caucasian women with evident signs of both chrono- and photoaging. Product efficacy was measured as follows: skin moisturization (corneometer), transepidermal water loss (tewameter), skin radiance, and color (spectrophotometer), skin elasticity and firmness (cutometer), skin roughness (image analysis), and skin thickness (ultrasound). Both intergroup and intragroup analysis proved that the daily intake of 225 mg of the active ingredient was enough to produce visible and structural improvements to the skin and to the signs of aging without any side effects. Statistically significant improvements compared to the placebo group were observed as early as 4 weeks regarding wrinkle depth, elasticity, firmness, skin thickness, skin moisturization, transepidermal water loss, and dark spots pigmentation. In addition, the subjects who consumed the blend reported better scores on the self-assessment questionnaires. Our results suggest that the intake of the test product can positively affect the appearance, barrier function, and skin density of aged skin after 12 weeks of treatment

Photoprotective and Antiaging Effects of a Standardized Red Orange (<i>Citrus sinensis</i> (L.) Osbeck) Extract in Asian and Caucasian Subjects: A Randomized, Double-Blind, Controlled Study

The increase in solar ultraviolet radiation (UVR) that reaches the Earth’s surface should make us reflect on the need to develop new approaches in protecting the skin from UVR exposure. The present study aims to evaluate the photoprotective and antiaging efficacy of a red orange extract (100 mg/day) in both Asian and Caucasian subjects. A randomized, double-blind, controlled study was carried out in 110 Asian and Caucasian subjects. Product efficacy was measured as follows: (1) the photoprotective effect was measured by the minimal erythema dose (MED) assessment; (2) the efficacy in decreasing the UVA+B-induced skin redness was measured by colorimetry; (3) the antioxidant efficacy was measured by the ferric-reducing antioxidant power (FRAP) and the malondialdehyde (MDA) assay; and (4) skin moisturization, skin elasticity, skin radiance, the intensity of melanin staining, transepidermal water loss (TEWL), and wrinkles were measured to assess the antiaging efficacy. The intake of the product for 56 days was effective in improving the skin reaction to UV exposure; in increasing the skin antioxidant capacity as well as in decreasing UVA-induced lipid peroxidation; in increasing the skin moisturization, skin elasticity, and skin radiance; and in decreasing TEWL, the intensity of melanin staining inside dark spots, and wrinkle depth. Our results suggest that the test product is effective in counteracting both the harmful effects of UVR exposure and aging signs

Skin photoprotective and antiageing effects of a combination of rosemary (Rosmarinus officinalis) and grapefruit (Citrus paradisi) polyphenols

Background: Plant polyphenols have been found to be effective in preventing ultraviolet radiation (UVR)-induced skin alterations. A dietary approach based of these compounds could be a safe and effective method to provide a continuous adjunctive photoprotection measure. In a previous study, a combination of rosemary (Rosmarinus officinalis) and grapefruit (Citrus paradisi) extracts has exhibited potential photoprotective effects both in skin cell model and in a human pilot trial. Objective: We investigated the efficacy of a combination of rosemary (R. officinalis) and grapefruit (C. paradisi) in decreasing the individual susceptibility to UVR exposure (redness and lipoperoxides) and in improving skin wrinkledness and elasticity. Design: A randomised, parallel group study was carried out on 90 subjects. Furthermore, a pilot, randomised, crossover study was carried out on five subjects. Female subjects having skin phototype from I to III and showing mild to moderate chrono- or photoageing clinical signs were enrolled in both studies. Skin redness (a* value of CIELab colour space) after UVB exposure to 1 minimal erythemal dose (MED) was assessed in the pilot study, while MED, lipoperoxides (malondialdehyde) skin content, wrinkle depth (image analysis), and skin elasticity (suction and elongation method) were measured in the main study. Results: Treated subjects showed a decrease of the UVB- and UVA-induced skin alterations (decreased skin redness and lipoperoxides) and an improvement of skin wrinkledness and elasticity. No differences were found between the 100 and 250 mg extracts doses, indicating a plateau effect starting from 100 mg extracts dose. Some of the positive effects were noted as short as 2 weeks of product consumption. Conclusions: The long-term oral intake of Nutroxsun™ can be considered to be a complementary nutrition strategy to avoid the negative effects of sun exposure. The putative mechanism for these effects is most likely to take place through the inhibition of UVR-induced reactive oxygen species and the concomitant inflammatory markers (lipoperoxides and cytokines) together with their direct action on intracellular signalling pathways