Association between the <i>FTO</i> and the MC4R polymorphisms and anthropometric measures. Crude means, odds ratio (OR) and unadjusted and adjusted^* regression coefficients (B).

<p>Values are means and standard deviations (SD), odds ratio (OR) and 95% confidence intervals (CI) or regression coefficients (B) and 95% CI.</p>1<p>: Unadjusted P values for the polymorphisms for the comparison of means or OR as categorical (three categories).</p><p>B: Regression coefficient per-variant allele effects (genotypes coded as 0, 1 and 2 according to the number of minor alleles; additive effects).</p>*<p>: Models adjusted for sex, age, center, diabetes, total energy intake and physical activity.</p>2<p>: P-values obtained in the adjusted regression models considering additive effects for the polymorphisms.</p

Demographic, clinical, lifestyle and genetic characteristics of the study participants according to the <i>FTO</i> and the <i>MC4R</i> polymorphisms at baseline^*.

*<p>: Values are means and standard deviations (SD) for continuous variables or percentages for categorical variables.</p>**<p>: Leisure time physical activity.</p>***<p>: Statistically significat differences (P<0.05) among genotypes.</p

Fixed and random parameters from a multilevel linear regression model of GSH-Px activity.

<p>Abbreviations: EEPA, daily energy expenditure in leisure-time physical activity. PHCC, primary health care center.</p>a<p>Adjusted β, regression coefficient of the association between each variable in the model and GSH-Px activity, controlling for the other variables in the model.</p>b<p>Random parameters are multilevel measures of outcome variation. PHCC was considered as random.</p><p>Fixed and random parameters from a multilevel linear regression model of GSH-Px activity.</p

Association between the aggregate genetic score of the <i>FTO</i> rs9939609 and <i>MC4R</i> rs17782313 and body mass index (BMI).

<p>Multivariate adjusted means. Error bars: SE of means. 0 points (non-variant alleles); 1 point (one variant allele either at <i>FTO</i> or <i>MC4R</i>; 2 points (two variant alleles), 3 points (3 variant alleles) and 4 points (4 variant alleles). P¹: unadjusted P-value for the comparison of means; P²: adjusted for sex, age, center, diabetes, energy intake and physical activity.</p

Association between the <i>FTO</i> rs9939609 and <i>MC4R</i> rs17782313 and alcohol intake in g/d (A) or drinking categories (B).

<p>Multivariate adjusted means of alcohol consumption depending on the genetic score of both polymorphisms (A) for the whole population (n = 7,019) or drinking categories (B) in men (n = 2,995). P¹: unadjusted; P²: adjusted for sex, age, center, diabetes, total energy intake and physical activity. Error bars: SE of means.</p

Hazard Ratios (95% confidence intervals) for total mortality according to quartiles of the waist-to-height ratio within each of the three intervention groups.

<p>The PREDIMED study 2003–2010.</p>1<p>Adjusted for age, sex, smoking, and family history of CHD.</p><p>All estimates are stratified for study center. The interaction term was not statistically significant (p = 0.056).</p

Participant characteristics by quintiles of serum glutathione peroxidase activity (U/L).

<p>Abbreviations: EEPA, daily energy expenditure in leisure-time physical activity. Data are shown as mean ±SD, median (interquartile range), or percentage.</p><p>* <i>P</i> value for trend adjusted for multiple testing using Holm correction <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0105881#pone.0105881-Holm1" target="_blank">[24]</a>. One-factor analysis of variance, nonparametric Kruskal Wallis test, and chi-square test were used as appropriate.</p><p>Participant characteristics by quintiles of serum glutathione peroxidase activity (U/L).</p

Association between the aggregate score of the <i>FTO</i> rs9939609 and the <i>MC4R</i> rs17782313 polymorphisms and dietary intake in the whole population. Crude and adjusted analyses.

<p>Values are unadjusted means and standard deviations (SD) or regression coefficients (B) and 95% confidence intervals (CI).</p>1<p>: Unadjusted P values for the score variable grouped as four categories.</p>*<p>: Models adjusted for sex, age, center, diabetes, physical activity and body mass index.</p>2<p>: P values for the B (lineal regression coefficient) corresponding to the aggregate score variable as additive (5 levels coded as 0,1,2,3 or 4 according to the number of variant alleles and adjusted for sex, age, field center, diabetes, physical activity and body mass index).</p

Interaction between the aggregate score (grouped) of the <i>FTO</i> rs9939609 and <i>MC4R</i> rs17782313 and adherence to the Mediterranean Diet (AdMedDiet) on BMI (A) or waist circumference (B).

<p>Adjusted means (n = 7,052) according and to the strata of AdMedDiet (below and above 9 points). Means were adjusted for sex, age, center, diabetes, total energy intake and physical activity. P values for the interaction terms were multivariate adjusted. In the stratified analysis by AdMedDiet, P values for mean comparisons of BMI or waist circumference between genotypes were multivariate adjusted (P₁ for the low AdMedDiet and P₂ for high). Error bars: SE of means.</p

Hazard Ratios (95% confidence intervals) for total mortality according to categories of body mass index.

<p>The PREDIMED study 2003–2010.</p>1<p>Adjusted for age, smoking, diabetes status, hypertensive status, intervention group and family history of CHD.</p><p>All estimates are stratified for study center.</p