Correlates of anemia among women of reproductive age in Ethiopia: Evidence from Ethiopian DHS 2005

Background: Globally, 41.8% of pregnant women and 30.2% of non-pregnant women are anemic. Previous studies which attempted to identify determinants of anemia among women of reproductive age reported conflicting findings. Objective: To assess the correlates of anemia among women of reproductive age in Ethiopia. Methods: A quantitative cross-sectional study carried out based on the secondary data of the Ethiopia Demographic Health Survey (EDHS) 2005. Data of a total of 5963 women of reproductive age were included in the analysis. Data were mainly analyzed using ANOVA and binary logistic regression. Result: The prevalence of anemia was 27.4% (95% CI: 26.3-28.5%). Rural residence, poor educational and economic status, 30-39 years of age and high parity were key factors predisposing women to anemia. Lactating women and those who gave birth in the month of the interview had 1.3 (p = 0.000) and 2.2 (p = 0.012) times higher risk than their counterparts. Those not using contraceptive were 1.4 times (p = 0.02) more likely to develop anemia than current contraceptive users. The average Dietary Diversity Score (DDS) was only 4.01, and not more than 15% of the respondents consumed iron rich foods in the preceding day of the survey. Respondents with low DDS and those who did not consume iron rich foods in the reference period had significantly higher risk of anemia with odds ratio of 1.3 (p = 0.01) and 1.3 (p = 0.002), respectively. Utilizing maternity services, taking iron and vitamin A supplement during pregnancy and postpartum period, respectively, didn’t have a significant effect in reducing the burden of anemia. Recommendation: Family planning, economic and educational empowerment of women have affirmative inputs in combating anemia. A combination of nutrition, educational and livelihood promotion strategies should be instated to enhance dietary diversity. Maternal nutrition interventions should be integrated in a stronger manner into maternity services

Improving sensitivity of oral fluid testing in IgG prevalence studies: application of mixture models to a rubella antibody survey

A method for the analysis of age-stratified antibody prevalence surveys is applied to a previously reported survey of antibody to rubella virus using oral fluid samples in which the sensitivity of the assay used was shown to be compromised. The age-specific distribution of the quantitative results of antibody tests using oral fluids is modelled as a mixture of strong positive, weak positive and negative components. This yields maximum likelihood estimates of the prevalence at each age and demonstrates that, when used in conjunction with mixture modelling techniques, the results of antibody prevalence studies using oral fluids accurately reflect those obtained using sera

The distribution and effects of child mortality risk factors in Ethiopia: A comparison of estimates from DSS and DHS

Objectives: To conduct a comparative analysis of the distribution and effects of under-five mortality correlates using Demographic and Health Survey (DHS) and Demographic Surveillance System (DSS) data from Ethiopia, and to investigate the methodological bias in DHS-based childhood mortality rates due to the impossibility of including children whose mothers were deceased. Methods: Using all-cause under-5 mortality as an outcome variable, the distribution and effects of risk factors weremodeled using survival analysis. All live births in rural Ethiopia in the 5-year period before the 2005 DSS+ survey and between 01/01/2000 and 31/12/2004 in the DSS in the Butajira Rural Health Program (in the Southern Nations, Nationalities, and People's (SNNP) region of Ethiopia) were included. Results: Overall, similar estimates of hazard rate ratios were derived from both DHS and DSS data and the child mortality risk profile is similar between each data source, with multiple births and living in less populous households being significant risk factors for under-five mortality. Nevertheless, some notable differences were observed. The DSS data was more sensitive to local variations in population composition and health status, whilst the more dispersed DHS approach tended to average out local variation across the country. Excluding children whose mothers were deceased from the DSS analysis had no important effect on risk profiles or estimates of survival functions at age 5 years. DHS survival functions were somewhat lower than DSS estimates (BRHP=0.87, DHS rural Ethiopia=0.67, DHS SNNP=0.66). Conclusion: Despite differing methodologies, cross-sectional DHS and longitudinal DSS data produce estimates of the distribution and effects of under-five mortality risk factors that are broadly similar. The differing methodological characteristics of DHS and DSS mean that when combined, these two data sources have the potential to provide a comprehensive picture of national population composition and health status as well as the extent of local variation –both of which are important for health monitoring and planning

An assessment of the health care system for diabetes in Addis Ababa, Ethiopia

Background: During the past decade, diabetes mellitus has emerged as an important clinical and public health problem through out the world. WHO estimated the number of cases of diabetics in Ethiopia to be about 800,000 in 2000, and projected that it would increase to about 1.8 million by the year 2030. Care for diabetic patients may require close and sustained support from a health care team, adequate financial resources, and advanced patient knowledge and motivation. In this respect, there is lack of information in the country.Objective: This study was conducted with the aim of assessing the characteristics of the health care system for diabetic patients, how diabetic patients are cared for including medical care and adequacy of facilities for the prevention of complications and outcomes at primary health care and secondary health care levels. Methods: An assessment of the characteristics of the health care system (structure) for diabetic patients was conducted in 21 health centres (primary health care level) and 5 regional hospitals (secondary health care level) in Addis Ababa. Furthermore, a total of 106 diabetic patients drawn from six out of the 21 health centres and another 123 diabetic patients drawn from three of the six hospitals were consecutively interviewed.Results: All the Regional hospitals and one of the health centres were running established diabetic referral clinics. Similarly, a lack of professionals was observed in all the health institutions in general and the health centres, in particular. Only 21% of patients had access for blood glucose monitoring at the same health institutions. The emphasis given for diabetic education (24%) was less than expected. Only 11 (5%) of diabetic patients were able to do self blood glucose monitoring at home. Fifty one percents of patients didn't have urine analysis, BUN, creatinine and lipid profile in the previous 1-2 years. None of diabetic patients had haemoglobin Alc (HbA1c) determination. Nearly 75% of the patients required admissions directly or indirectly due to uncontrolled diabetes. About 87% of the diabetics had regular follow ups at their respective health centres and hospitals. Hypertension (34%), diabetes related eye disease (33%) and renal disease (21%) were the major associated illnesses observed among the diabetics. Sixty-six patients (23%) had a total of about 131 admissions.Conclusion: Although there is a well-established health infrastructure for diabetics care in Addis Ababa, the diabetic care is below the acceptable standard. The finding of this study may, thus, help to clarify issues related to potential changes in the health care system dealing with diabetes and for strengthening the referral system for diabetes health care. Ethiopian Journal of Health Development Vol. 19(3) 2005: 203-21

A case control study on determinants of diarrheal morbidity among under-five children in Wolaita Soddo Town, Southern Ethiopia

Background: Diarrheal disease is the most common cause of illness and the second leading cause of child death in the world. The disease accounts for 4.3% of the total global disease burden; the burden being greatest in the developing world including Ethiopia.Objective: The aim was to assess potential determinant factors associated with diarrheal morbidity among under-five children in Wolaita Soddo Town, South Ethiopia.Methods: A community-based case control study on 198 cases and 396 controls was conducted in Southern Ethiopia; cases were under-five children with diarrhea in the last 15 days of recall period. Three kebeles (one kebele from each sub-city) were first selected by a lottery method. Then a house to house survey was conducted to enumerate under-five children in the selected kebeles. During the enumeration identification number was given for the households with name and age of the child which was used as a sampling frame for the selecting cases and controls. For each case, two controls were selected randomly. Odds ratios with 95% confidence intervals were calculated to show the strength of association.Results: The odds of developing diarrheal morbidity was 2.6 times higher among children with fathers having no formal education compared to those with fathers educational status of high school completed (Adj OR=2.56,  95% CI:1.25, 5.25). Cases were about 4 times higher among families perceived that were to be economically very poor compared to families perceived rich or medium (Adj OR=.3.84, 95% CI:1.25, 11.82). Children in households with no latrine were about 13.5 times (Adj OR=13.45, 95% CI:3.58, 50.49) more likely to develop diarrhea compared to children with households with latrines. Treatment of drinking water showed a significant odds (Adj OR=2.34, 95% CI:1.33, 4.14) of developing diarrhea. Similarly, diarrheal diseases were higher among children whose mothers have poor knowledge of transmission methods and those who washed hands less frequently compared to those who did.Conclusion: Poor housing, poor sanitation conditions, poor personal hygiene, and lack of relevant knowledge are strongly associated with the occurrence of diarrheal disease among children of under-five years of age. Health education should be given to the public especially to mothers and caretakers on personal hygiene

HIV-infected adolescents have low adherence to antiretroviral therapy: a cross-sectional study in Addis Ababa, Ethiopia

Introduction: For antiretroviral therapy (ART) to work effectively, adherence is very crucial. However, most studies done on ART adherence are either on children or on adults. There is limited information on the level of adherence among adolescents.Methods: Using a cross-sectional study design, we interviewed 273 HIV-infected adolescents receiving ART from three hospitals in Addis Ababa. We used a structured questionnaire to measure adherence levels using patient self-reports. Bivariate and multivariate methods were used for analysis.Results: We interviewed 273 adolescents aged 13 to 19 years, and 144 (52.7%) of the participants were girls. Their mean age was 15.4 years (SD± 1.75). The self-reported adherence rate of the respondents was 79.1% (216/273). On bivariate analysis, variables like WHO clinical stage, being on Cotrimoxazole Prophylactic Therapy (CPT), marital and living status of the parent, whether parent was on ART or not and having special instructions for ART medications were associated with optimum adherence. However of those, only WHO stage IV (adjusted OR, 12.874 95% CI, 2.079-79.706), being on CPT (adjusted OR, 0.339 95% CI, 0.124-0.97) and adolescents with widowed parent (adjusted OR, 0.087 with 95% CI, 0.021-0.359) were found to be significantly associated with optimum ART adherence.Conclusion: The level of self-reported ART adherence among HIV-infected adolescents at the three hospitals was below the recommended threshold. Though earlier presentation of adolescents to care should be encouraged, more targeted adherence support should be planned for those who present at an early stage of their illness.Keywords: Antiretroviral therapy, adherence, adolescent, patient self-report, Addis Ababa, Ethiopi

Seroepidemiology of hepatitis B virus in Addis Ababa Ethiopia: transmission patterns and vaccine control

A community-based seroepidemiological survey of Addis Ababa, Ethiopia was conducted in 1994 to inform on the transmission dynamics and control of hepatitis B virus (HBV) infection. Venous blood from 4736 individuals under 50 years of age from 1262 households, selected using stratified cluster-sampling, was screened for HBV markers using commercial ELISAs. HBsAg prevalence was 7% (95% CI 6–8), higher in males (9%; 7–10) than females (5%; 4–6). HBeAg prevalence in HBsAg positives was 23% (18–29), and less than 1% of women of childbearing age were HBeAg positive. Overall HBV seroprevalence (any marker), rose steadily with age to over 70% in 40–49 year olds, indicating significant childhood and adult transmission. Estimated instantaneous incidence was 3–4/100 susceptibles/year, higher in males than females in 0–4 year olds, and peaking in early childhood and young adults. The age at which 50% had evidence of infection was around 20 years, and the herd immunity threshold is approximated at 63–77%. Addis Ababa is of intermediate-high HBV endemicity, with negligible perinatal transmission. Our main findings are the identification of a significant difference between males and females in the age-acquisition of HBV infection, and marked differences between age groups in HBV incidence rates. These results should target future research studies of underlying risk factors. Furthermore, we generate a crude estimate of the level of coverage of HBV vaccine that would be required to eliminate the virus from the study population

Sero-epidemiology of rubella in the urban population of Addis Ababa Ethiopia

We conducted a community-based cluster sample survey of rubella sero-epidemiology in Addis Ababa, Ethiopia in 1994. Among 4666 individuals for whom complete data were available, rubella antibody prevalence was 91% (95% confidence interval: 90, 92). On multivariable analysis, seroprevalence was lower among individuals who were resident in Addis Ababa for 1 year or less. Approx. 50% seroprevalence was attained by age 4 years, and the estimated average age at infection was 5·2 years. The highest age-specific force of infection was estimated to occur in 5- to 9-year-olds. The early age at infection corresponded with a low estimated incidence of congenital rubella syndrome (CRS) of 0·3 per 1000 live births, equivalent to nine cases of CRS in 1994. The predicted critical level of immunity for elimination of rubella via vaccination was 85–91%, requiring 89–96% coverage with a vaccine of 95% effectiveness. Unless very high coverage of rubella vaccine could be guaranteed, the introduction of childhood vaccination could increase the incidence of CRS in Addis Ababa

Prevalence and factors affecting use of long acting and permanent contraceptive methods in Jinka town, Southern Ethiopia: a cross sectional study

Introduction: In Ethiopia, knowledge of contraceptive methods is high though there is low contraceptive prevalence rate. This study was aimed to assess prevalence and associated factors of long acting and permanent contraceptive methods in Jinka town, southern Ethiopia. Methods: Community based cross sectional survey was conducted to assess the prevalence and factors affecting long acting and permanent methods of contraceptives utilization from March to April 2008. Eight hundred child bearing age women were participated in the quantitative study and 32 purposively selected focus group discussants were participated in the qualitative study. Face to face interview was used for data collection. Data were analyzed by SPSS version 13.0 statistical software. Descriptive statistics and logistic regression were computed to analyze the data. Results: The prevalence of long acting and permanent contraceptive method was 7.3%. Three fourth  (76.1%) of the women have ever heard about implants and implant 28 (50%) were the most widely used method. Almost two third of women had intention to use long acting and permanent methods. Knowledge of contraceptive and age of women have significant association with the use of long acting and permanent contraceptive methods.Conclusion: The overall prevalence of long acting and permanent contraceptive method was low.  Knowledge of contraceptive and age of women have significant association with use of long acting and permanent contraceptive. Extensive health information should be provided.Key words: Long acting, permanent, contraceptive, women, Ethiopi

Evaluation of a measles vaccine campaign by oral-fluid surveys in a rural Kenyan district: interpretation of antibody prevalence data using mixture models

We evaluated the effectiveness of a measles vaccine campaign in rural Kenya, based on oral-fluid surveys and mixture-modelling analysis. Specimens were collected from 886 children aged 9 months to 14 years pre-campaign and from a comparison sample of 598 children aged 6 months post-campaign. Quantitative measles-specific antibody data were obtained by commercial kit. The estimated proportions of measles-specific antibody negative in children aged 0–4, 5–9 and 10–14 years were 51%, 42% and 27%, respectively, pre- campaign and 18%, 14% and 6%, respectively, post-campaign. We estimate a reduction in the proportion susceptible of 65–78%, with ~85% of the population recorded to have received vaccine. The proportion of ‘weak’ positive individuals rose from 35% pre-campaign to 54% post-campaign. Our results confirm the effectiveness of the campaign in reducing susceptibility to measles and demonstrate the potential of oral-fluid studies to monitor the impact of measles vaccination campaigns