Synthesis, Crystal Structure, Vibrational Spectra, and Thermochemical Transformations of Tris(hydroxymethyl)aminomethane

Abstract—A practically promising compound, tris(hydroxymethyl)aminomethane sulfate ((TRISH)2SO4, C8H24N2O10S) was synthesized and studied by a set of experimental methods (elemental analysis, IR and Raman spectroscopy, mass spectrometry, thermogravimetry)

Synthesis, Crystal Structure, and Spectral Characteristics of N-(tert-Butyl) aminomethanesulfonic Acid

A new method of the synthesis of N-(tert-butyl)aminomethanesulfonic acid in the system SO2–(CH3)3CNH2–CH2O–H2O was developed. The target compound [(CH3)3С]NHCH2SO3H was characterized by means of X-ray diffraction analysis, IR spectroscopy, and mass spectrometry

Interaction Products in the System Sulfur Dioxide–2,2′-Bipyridine–Water. Van der Waals Clathrates

Crystallization of 2,2′-bipyridine from aqueous solution containing sulfur(IV) oxide afforded clathrates with the composition (bipy)k·(SO2)m·(H2O)n. X-Ray amorphous guest SO2 molecules occupy voids in the crystal lattice of 2,2′-bipyridine without distortion of its structure. The isolated compounds were characterized by elemental analyses, X-ray diffraction data, and IR, NMR, and mass spectra

Products of Interaction between Sulfur(IV) Oxide and Aqueous Solutions of Hexamethylendiamine and tertButylamine: The Crystal Structure of Hexamethylenediammonium Sulfate Dihydrate

The possibility of mild SO2 oxidation in sulfur(IV) oxide–alkylamine–water–oxygen systems is demonstrated to yield onium sulfates

Synthesis, Spectral Characteristics, and Some Properties of Methylammonium Sulfamate Monohydrate. A New Route to Sulfamic Acid Derivatives

Abstract—Redox transformations of the products of reactions of the CH3C(S)NH2–SO2–H2O system components yield methylammonium sulfamate monohydrate [CH3NH3] +[OSO2NH2] – H2O and elemental sulfur. The synthesized compound was characterized by IR, 1 H and 13C NMR, and mass spectroscopy and some of its properties were studied

Onium Salts of Sulfur-Containing Oxyanions Resulting from Reaction of Sulfur(IV) Oxide with Aqueous Solutions of 1,2-Diamines and Morpholine

Reaction products have been isolated from SO2–L–H2O–О2 systems (L = ethylenediamine, N,N,N',N'-tetramethylethylenediamine, piperazine, and morpholine) as onium salts [H3NCH2CH2NH3]SO4, [(CH3)2NHCH2CH2NH(CH3)2]SO4, [(CH3)2NHCH2CH2NH(CH3)2]S2O6 ⋅ H2O, [C4H8N2H4]SO3 ⋅ H2O, [C4H8N2H4]S2O6, [C4H8N2H4]SO4 ⋅ H2O, [O(C2H4)2NH2]2SO4 ⋅ H2O. The prepared compounds have been characterized by X-ray diffraction analysis, X-ray powder diffraction, IR and mass spectroscopy

Onium Sulfates and Hydrogen Sulfates: Products of Reactions of Sulfur(IV) Oxide with Aqueous Solutions of Alkylamines and Aniline

The reaction products formed in the SO2–L–H2O–O2 systems (L is n-propylamine, n-butylamine, tert-butylamine, n-heptylamine, n-octylamine, aniline) were isolated and identified as “onium” salts [n-C3H7NH3]2SO4, [n-C4H9NH3]2SO4, [t-C4H9NH3]2SO4, [n-C7H15NH3]3SO4(HSO4), [n-C8H17NH3]3SO4(HSO4), and [C6H5NH3]2SO4. The products were characterized by elemental analysis, IR and Raman spectroscopy, mass spectrometry, and thermogravimetry

Preparation and Some Physicochemical Properties of Benzylammonium Sulfates

New method of preparation of multisubstituted benzylammonium cations via interaction in the SO2–L–H2O systems (L is benzylamine, α-phenylethylamine, N,N-dimethylbenzylamine, or dibenzylamine) has been developed. The products have been studied by X-ray diffraction, IR, Raman spectroscopy, and mass spectrometry

Synthesis and Structure of N(Hydroxyethyl)ethylenediammonium Sulfite Monohydrate

A reaction between sulfur(IV) oxide and aqueous N(2hydroxyethyl)ethylenediamine yields onium sulfite of composition (HOCH2CH2NH2CH2CH2NH3)SO3 ⋅ H2O, which has been characterized by Xray diffraction, IR spectroscopy, and mass spectrometry. The threedimensional structure of the salt is stabilized by numerous hydrogen bonds, such as NH⋅⋅⋅O and OH⋅⋅⋅O

Investigations of the antimicrobial activity of aminomethanesulfonic acids against strains of Staphylococcus aureus with different antimicrobial susceptibility

One of the tasks of the WHO strategy against development of antibiotic resistance in microorganisms is the searching for new compounds with antimicrobial activity to develop new antimicrobial medicines. The aim of this study was to determine the inhibitory effect of aminosulfonic acid (AMSA) and its new derivatives such as N-methyl-(MeAMSA), N-(2-hydroxyethyl)-(HEAMSA), N-benzyl-(BnAMSA), N-(tert-butyl)-(t-BuAMSA), 4-(N-phenylaminomethyl)phenyl (PhAMPhAMSA) on the growth of Staphylococcus aureus strains with different antimicrobial susceptibility. Materials and methods. The method of serial dilution was used in the study. The chemical compounds were dissolved in DMSO (a final concentration of 1%). Then dilutions of the compounds were performed using liquid Mueller-Hinton medium to final concentrations of 5 mM and 10 m×M. The results were assessed using a Densi-La-Meter after 18-20 hours of incubation at 37 °C. Sulfanilamide was used as a reference preparation. Results. AMSA suppressed the growth of all tested strains regardless of their antibiotic resistance profiles even more than sulfanilamide. MeAMSA inhibited the growth of S. aureus ATCC 25923 and S. aureus 2781 strains more than the reference preparation, but less than AMSA. No inhibitory effect was observed on the antibiotic resistant S. aureus Kunda strain. Compounds of HEAMSA, t-BuAMSA, BnAMSA stably inhibited the growth of all strains tested. These compounds suppressed the growth of S. aureus ATCC 25923 and S. aureus Kunda strains more than sulfanilamide. However, the reference preparation exhibited greater S. aureus 2781 growth inhibition than investigated preparations. Compound PhAMPhAMSA did not show antimicrobial activity. Conclusions. Aminomethanesulfonic acid derivatives suppressed the growth of Staphylococcus aureus strains with different antimicrobial susceptibility and their antimicrobial activity was higher than that of sulfanilamide. Further study of these compounds efficacy on different types of microorganisms can be considered promising for the development of new antimicrobial agents. It would also be appropriate to study the combined use of these substances with antibiotics