3,751 research outputs found
Point-of-care measurement of blood lactate in children admitted with febrile illness to an African District Hospital.
BACKGROUND: Lactic acidosis is a consistent predictor of mortality owing to severe infectious disease, but its detection in low-income settings is limited to the clinical sign of "deep breathing" because of the lack of accessible technology for its measurement. We evaluated the use of a point-of-care (POC) diagnostic device for blood lactate measurement to assess the severity of illness in children admitted to a district hospital in Tanzania. METHODS: Children between the ages of 2 months and 13 years with a history of fever were enrolled in the study during a period of 1 year. A full clinical history and examination were undertaken, and blood was collected for culture, microscopy, complete blood cell count, and POC measurement of blood lactate and glucose. RESULTS: The study included 3248 children, of whom 164 (5.0%) died; 45 (27.4%) of these had raised levels of blood lactate (>5 mmol/L) but no deep breathing. Compared with mortality in children with lactate levels of ≤ 3 mmol/L, the unadjusted odds of dying were 1.6 (95% confidence interval [CI].8-3.0), 3.4 (95% CI, 1.5-7.5), and 8.9 (95% CI, 4.7-16.8) in children with blood lactate levels of 3.1-5.0, 5.1-8.0, or >8.0 mmol/L, respectively. The prevalence of raised lactate levels (>5 mmol/L) was greater in children with malaria than in children with nonmalarial febrile illness (P < .001) although the associated mortality was greater in slide-negative children. CONCLUSIONS: POC lactate measurement can contribute to the assessment of children admitted to hospital with febrile illness and can also create an opportunity for more hospitals in resource-poor settings to participate in clinical trials of interventions to reduce mortality associated with hyperlactatemia
More Aeschynomene Pasture Legumes for the Tropics and Sub-Tropics
Two cultivars of Aeschynomene villosa were released in Queensland in 1995. Cultivars ‘Reid’ (previously CPI 91209) and ‘Kretschmer’ (previously CPI 93621) are both native to Mexico and are the first cultivars of A. villosa to be released as pasture legumes. They will complement the three Aeschynomene cultivars already in use in tropical and sub-tropical northern and eastern Australia, namely cultivars ‘Glenn’ and ‘Lee’ (A. americana) and ‘Bargoo’ (A. falcata). Characteristics of Reid and Kretschmer jointvetch include, early seeding perennials within high seed yields, prostrate to semi-erect growth habit, adaptation to a wide range of soil types in medium rainfall areas, tolerance of temporary waterlogging, palatability of high quality forage, responsive to added phosphorus, and tolerance of light frosts. Commercial seed will be available for sale about October, 1997. Reid and Kretschmer villose jointvetch are widely adapted high quality pasture legumes which will complement current legume cultivars and will broaden the scope for sown pasture development in sub-tropical and tropical northern Australia
Unusually large polarizabilities and "new" atomic states in Ba
Electric polarizabilities of four low-J even-parity states and three low-J
odd-parity states of atomic barium in the range to $36,000\
^{-1}6s8p
^3P_{0,2}$ is suggested.Comment: 29 pages, 12 figure
09_05_01_Hopkinson_English.indd
Abstract To fi nd ways of improving the sowing value of seed of tropical pasture grasses through attention to the storage environment used commercially, fresh seed lots of Panicum maximum, Brachiaria decumbens, Brachiaria humidicola, Setaria sphacelata and Chloris gayana were stored under different conditions and sampled periodically for laboratory, greenhouse and fi eld testing. Comparisons were made between seed lots stored in bags of open weave in a cool-room at 10°C and 50% RH and in an open store-room at ambient temperature. Seed lots of P. maximum in moisture-proof packets at 5 different moisture contents between 7.3 and 12.9% were compared. One seed lot was also freezer-stored at -12°C. Part 1 reports their viability and dormancy loss. Viability loss of seed in woven bags in open storage was complete within 3 years while barely detectable in similar cool-stored seed. Rates of loss in sealed packets increased with moisture content at ambient temperatures. They were much higher in seed in woven bags at comparable average moisture contents, an effect attributed largely to spatial moisture content gradients. Cool storage temperatures and low seed moisture contents appeared to prolong dormancy, while freezer storage retained and even intensifi ed it. Introduction By the early 1990s, our need to improve the storage environment of seeds of tropical pasture grasses had become urgent. A developing responsibility for maintenance of pedigree seed stocks required a sound strategy for medium-term storage. Increasing pressure on the seed industry to improve the quality of its products for a competitive export market translated into demands upon us for information on storage that could not be adequately satisfi ed. Progress in understanding pre-storage infl uences on quality (e.g. Hopkinson and English 2004) emphasised our ignorance of subsequent seed history. While general principles of deterioration of orthodox seeds in storage were well established The construction of a cool-room at Walkamin Research Station in 1992 allowed us to compare the performance of seed stored in a single set of constant, defi ned conditions with that of seed of the same origin kept in conventional open storage. Comparisons were later extended to seed stored at a range of constant moisture contents. From these, we sketched the fi rst bare outline of the effects of storage environment on subsequent seed characteristics. This paper describes the experiments done, and reports the changes in viability and dormancy measured by laboratory tests under various storage conditions. Impacts on seedling emergence from soil, dormancy in soil, vigour and fi eld sowing value will be covered in a second paper (Hopkinson and English 2005)
A new Geoengineering Model Intercomparison Project (GeoMIP) experiment designed for climate and chemistry models
A new Geoengineering Model Intercomparison Project (GeoMIP) experiment "G4 specified stratospheric aerosols" (short name: G4SSA) is proposed to investigate the impact of stratospheric aerosol geoengineering on atmosphere, chemistry, dynamics, climate, and the environment. In contrast to the earlier G4 GeoMIP experiment, which requires an emission of sulfur dioxide (SO2) into the model, a prescribed aerosol forcing file is provided to the community, to be consistently applied to future model experiments between 2020 and 2100. This stratospheric aerosol distribution, with a total burden of about 2 Tg S has been derived using the ECHAM5-HAM microphysical model, based on a continuous annual tropical emission of 8 Tg SO2 yr−1. A ramp-up of geoengineering in 2020 and a ramp-down in 2070 over a period of 2 years are included in the distribution, while a background aerosol burden should be used for the last 3 decades of the experiment. The performance of this experiment using climate and chemistry models in a multi-model comparison framework will allow us to better understand the impact of geoengineering and its abrupt termination after 50 years in a changing environment. The zonal and monthly mean stratospheric aerosol input data set is available at https://www2.acd.ucar.edu/gcm/geomip-g4-specified-stratospheric-aerosol-data-set
Target mass number dependence of subthreshold antiproton production in proton-, deuteron- and alpha-particle-induced reactions
Data from KEK on subthreshold \bar{\mrm{p}} as well as on and
\mrm{K}^\pm production in proton-, deuteron- and -induced reactions
at energies between 2.0 and 12.0 A GeV for C, Cu and Pb targets are described
within a unified approach. We use a model which considers a nuclear reaction as
an incoherent sum over collisions of varying numbers of projectile and target
nucleons. It samples complete events and thus allows for the simultaneous
consideration of all final particles including the decay products of the
nuclear residues. The enormous enhancement of the \bar{\mrm{p}} cross
section, as well as the moderate increase of meson production in deuteron and
induced compared to proton-induced reactions, is well reproduced for
all target nuclei. In our approach, the observed enhancement near the
production threshold is mainly due to the contributions from the interactions
of few-nucleon clusters by simultaneously considering fragmentation processes
of the nuclear residues. The ability of the model to reproduce the target mass
dependence may be considered as a further proof of the validity of the cluster
concept.Comment: 9 pages, 4 figure
Significance of Off-Center Rattling for Emerging Low-lying THz Modes in type-I Clathrates
We show that the distinct differences of low-lying THz-frequency dynamics
between type-I clathrates with on-center and off-center guest ions naturally
follow from a theoretical model taking into account essential features of the
dynamics of rattling guest ions. Our model analysis demonstrates the drastic
change from the conventional dynamics shown by on-center systems to the
peculiar dynamics of off-center systems in a unified manner. We claim that
glass-like plateau thermal conductivities observed for off-center systems stem
from the flattening of acoustic phonon dispersion in the regime |k|<|G|/4. The
mechanism is applicable to other systems such as glasses or relaxers
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