EFEITOS DA POLÍTICA DE SALÁRIO MÍNIMO SOBRE O MERCADO DE TRABALHO METROPOLITANO: UMA ANÁLISE EMPÍRICA A PARTIR DE VETORES AUTORREGRESSIVOS (VAR) - (2003-2015)

RESUMO Com intuito de verificar os efeitos que a política de salário mínimo exerce sobre o mercado de trabalho metropolitano brasileiro, o presente estudo contribui ao verificar a sua inter-relação com variáveis como taxa de atividade, grau de informalidade e taxa de desemprego em quatro regiões metropolitanas (Recife, Porto Alegre, Belo Horizonte e São Paulo), separadamente, no período de janeiro de 2003 a março de 2015. Ao utilizar o método de autorregressão vetorial (VAR), os resultados mostram que a relação entre salário mínimo e taxa de atividade se deu com ingresso de mão de obra apenas em uma região estudada. Nas demais regiões observam-se tanto uma tendência de queda no grau de informalidade quanto um aumento na taxa de desemprego

CCL5-mediated endogenous antitumor immunity elicited by adoptively transferred lymphocytes and dendritic cell depletion. Cancer Res 69: 6331

Abstract Adoptive transfer of antitumor T cells is a promisingly effective therapy for various cancers, but its effect on endogenous antitumor immune mechanisms remains largely unknown. Here, we show that the administration of naive T cells de novo primed for only 7 days against tumor antigens resulted in the durable rejection of otherwise lethal ovarian cancers when coupled with the depletion of tumor-associated immunosuppressive dendritic cells (DC). Therapeutic activity required tumor antigen specificity and perforin expression by the adoptively transferred T cells, but not IFN-; production. Importantly, these shortly primed T cells secreted large amounts of CCL5, which was required for their therapeutic benefit. Accordingly, transferred T cells recruited CCR5 + DCs into the tumor, where they showed distinct immunostimulatory attributes. Activated CCR5 + host T cells with antitumor activity also accumulated at tumor locations, and endogenous tumor-specific memory T cells remained elevated after the disappearance of transferred lymphocytes. Therefore, persistent, long-lived antitumor immunity was triggered by the administration of ex vivo activated T cells, but was directly mediated by immune cells of host origin. Our data unveil a CCL5-dependent mechanism of awakening endogenous antitumor immunity triggered by ex vivo expanded T cells, which is augmented by tumor-specific targeting of the cancer microenvironment. [Cancer Res 2009;69(15):6331-8